Motif ID: Hnf1a

Z-value: 0.542


Transcription factors associated with Hnf1a:

Gene SymbolEntrez IDGene Name
Hnf1a ENSMUSG00000029556.6 Hnf1a



Activity profile for motif Hnf1a.

activity profile for motif Hnf1a


Sorted Z-values histogram for motif Hnf1a

Sorted Z-values for motif Hnf1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf1a

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_53286052 1.461 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr19_-_14597983 1.459 ENSMUST00000052011.7
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr19_-_14598031 1.429 ENSMUST00000167776.2
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr9_-_106158109 1.208 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
 Glyctk



glycerate kinase



chr10_-_30842765 0.899 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr17_-_35132050 0.869 ENSMUST00000025249.6
 Apom
apolipoprotein M
chr7_+_141216626 0.831 ENSMUST00000141804.1
ENSMUST00000148975.1
 Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr2_-_68472138 0.781 ENSMUST00000102715.3
 Stk39
serine/threonine kinase 39
chr7_-_144751968 0.746 ENSMUST00000155175.1
 Ano1
anoctamin 1, calcium activated chloride channel
chr7_+_141215852 0.744 ENSMUST00000046890.5
ENSMUST00000133763.1
 Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr11_-_11898044 0.673 ENSMUST00000066237.3
 Ddc
dopa decarboxylase
chr11_-_11898092 0.637 ENSMUST00000178704.1
 Ddc
dopa decarboxylase
chr6_+_38918969 0.603 ENSMUST00000003017.6
 Tbxas1
thromboxane A synthase 1, platelet
chr4_-_97778042 0.523 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr15_-_42676967 0.504 ENSMUST00000022921.5
 Angpt1
angiopoietin 1
chr10_+_63061582 0.457 ENSMUST00000020266.8
ENSMUST00000178684.1
 Pbld1

phenazine biosynthesis-like protein domain containing 1

chr18_+_33464163 0.430 ENSMUST00000097634.3
 Gm10549
predicted gene 10549
chr1_+_172698046 0.414 ENSMUST00000038495.3
 Crp
C-reactive protein, pentraxin-related
chr9_+_99629496 0.401 ENSMUST00000131095.1
ENSMUST00000078367.5
ENSMUST00000112885.2
 Dzip1l


DAZ interacting protein 1-like


chr16_+_20651652 0.400 ENSMUST00000007212.8
 Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr9_-_71163224 0.383 ENSMUST00000074465.2
 Aqp9
aquaporin 9
chr5_+_8046077 0.363 ENSMUST00000088786.4
 Sri
sorcin
chr7_-_79842287 0.340 ENSMUST00000049004.6
 Anpep
alanyl (membrane) aminopeptidase
chr2_+_110597298 0.298 ENSMUST00000045972.6
ENSMUST00000111026.2
 Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr11_+_3983636 0.282 ENSMUST00000078757.1
 Gal3st1
galactose-3-O-sulfotransferase 1
chr7_+_140763739 0.280 ENSMUST00000026552.7
 Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr19_-_47919269 0.267 ENSMUST00000095998.5
 Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr9_+_57827284 0.259 ENSMUST00000163186.1
 Gm17231
predicted gene 17231
chr9_+_99629823 0.253 ENSMUST00000112886.2
 Dzip1l
DAZ interacting protein 1-like
chr13_+_83738874 0.220 ENSMUST00000052354.4
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr11_+_3983704 0.201 ENSMUST00000063004.7
 Gal3st1
galactose-3-O-sulfotransferase 1
chr10_-_76110956 0.190 ENSMUST00000120757.1
 Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr2_-_155357392 0.176 ENSMUST00000165234.1
ENSMUST00000077626.6
 Pigu

phosphatidylinositol glycan anchor biosynthesis, class U

chr10_+_87859255 0.170 ENSMUST00000105300.2
 Igf1
insulin-like growth factor 1
chr14_+_79515618 0.159 ENSMUST00000110835.1
 Elf1
E74-like factor 1
chr18_-_33463747 0.139 ENSMUST00000171533.1
 Nrep
neuronal regeneration related protein
chr19_+_6105774 0.136 ENSMUST00000044451.3
 Naaladl1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr6_+_29859374 0.136 ENSMUST00000115238.3
 Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr5_+_122391878 0.125 ENSMUST00000102525.4
 Arpc3
actin related protein 2/3 complex, subunit 3
chrX_+_101377267 0.113 ENSMUST00000052130.7
 Gjb1
gap junction protein, beta 1
chr3_+_136670076 0.100 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr18_-_33464007 0.096 ENSMUST00000168890.1
 Nrep
neuronal regeneration related protein
chr14_-_70630149 0.086 ENSMUST00000022694.9
 Dmtn
dematin actin binding protein
chr19_+_42045792 0.070 ENSMUST00000172244.1
ENSMUST00000081714.4
 Hoga1

4-hydroxy-2-oxoglutarate aldolase 1

chrX_-_43167817 0.049 ENSMUST00000115058.1
ENSMUST00000115059.1
 Tenm1

teneurin transmembrane protein 1

chr6_+_29859662 0.044 ENSMUST00000128927.2
 Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr11_+_78178105 0.044 ENSMUST00000147819.1
 Tlcd1
TLC domain containing 1
chr10_+_87859062 0.044 ENSMUST00000095360.4
 Igf1
insulin-like growth factor 1
chrX_+_101376359 0.032 ENSMUST00000119080.1
 Gjb1
gap junction protein, beta 1
chr6_+_29859686 0.030 ENSMUST00000134438.1
 Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr4_+_150853919 0.023 ENSMUST00000073600.2
 Errfi1
ERBB receptor feedback inhibitor 1
chr8_-_95142477 0.017 ENSMUST00000034240.7
ENSMUST00000169748.1
 Kifc3

kinesin family member C3

chr2_-_86347764 0.014 ENSMUST00000099894.2
 Olfr1055
olfactory receptor 1055
chr9_+_108795971 0.013 ENSMUST00000085018.4
 Ip6k2
inositol hexaphosphate kinase 2
chr7_-_119895446 0.013 ENSMUST00000098080.2
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr15_-_79285502 0.009 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr19_-_30549516 0.005 ENSMUST00000025803.8
 Dkk1
dickkopf homolog 1 (Xenopus laevis)
chr11_-_98022594 0.001 ENSMUST00000103144.3
ENSMUST00000017552.6
ENSMUST00000092736.4
ENSMUST00000107562.1
 Cacnb1



calcium channel, voltage-dependent, beta 1 subunit



chr9_+_53771499 0.000 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0003195 tricuspid valve formation(GO:0003195)
0.3 1.5 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.3 0.8 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016) regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.2 1.3 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.2 0.9 GO:0050748 negative regulation of lipoprotein metabolic process(GO:0050748)
0.2 0.5 GO:0030210 heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.2 0.5 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.7 GO:0015705 iodide transport(GO:0015705)
0.1 0.6 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 0.2 GO:1904192 regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142) cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.1 0.4 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.4 GO:0055118 negative regulation of cardiac muscle contraction(GO:0055118)
0.1 0.4 GO:0032782 bile acid secretion(GO:0032782)
0.1 0.5 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.2 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.1 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.0 0.3 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.0 0.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.1 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.0 0.3 GO:0019369 drug metabolic process(GO:0017144) arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 2.4 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.1 0.4 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.3 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.9 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.3 0.9 GO:0035939 microsatellite binding(GO:0035939)
0.2 0.7 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.1 0.5 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.1 0.4 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.3 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 1.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 3.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.2 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.2 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.6 GO:0004497 monooxygenase activity(GO:0004497)
0.0 0.9 GO:0016209 antioxidant activity(GO:0016209)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.8 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.4 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.7 PID_SHP2_PATHWAY SHP2 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 0.4 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.9 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 3.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.4 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.5 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.1 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly