Motif ID: Hnf1a

Z-value: 0.542


Transcription factors associated with Hnf1a:

Gene SymbolEntrez IDGene Name
Hnf1a ENSMUSG00000029556.6 Hnf1a



Activity profile for motif Hnf1a.

activity profile for motif Hnf1a


Sorted Z-values histogram for motif Hnf1a

Sorted Z-values for motif Hnf1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf1a

PNG image of the network

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Top targets:


Showing 1 to 20 of 59 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_53286052 1.461 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr19_-_14597983 1.459 ENSMUST00000052011.7
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr19_-_14598031 1.429 ENSMUST00000167776.2
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr9_-_106158109 1.208 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
 Glyctk



glycerate kinase



chr10_-_30842765 0.899 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr17_-_35132050 0.869 ENSMUST00000025249.6
 Apom
apolipoprotein M
chr7_+_141216626 0.831 ENSMUST00000141804.1
ENSMUST00000148975.1
 Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr2_-_68472138 0.781 ENSMUST00000102715.3
 Stk39
serine/threonine kinase 39
chr7_-_144751968 0.746 ENSMUST00000155175.1
 Ano1
anoctamin 1, calcium activated chloride channel
chr7_+_141215852 0.744 ENSMUST00000046890.5
ENSMUST00000133763.1
 Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr11_-_11898044 0.673 ENSMUST00000066237.3
 Ddc
dopa decarboxylase
chr11_-_11898092 0.637 ENSMUST00000178704.1
 Ddc
dopa decarboxylase
chr6_+_38918969 0.603 ENSMUST00000003017.6
 Tbxas1
thromboxane A synthase 1, platelet
chr4_-_97778042 0.523 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr15_-_42676967 0.504 ENSMUST00000022921.5
 Angpt1
angiopoietin 1
chr10_+_63061582 0.457 ENSMUST00000020266.8
ENSMUST00000178684.1
 Pbld1

phenazine biosynthesis-like protein domain containing 1

chr18_+_33464163 0.430 ENSMUST00000097634.3
 Gm10549
predicted gene 10549
chr1_+_172698046 0.414 ENSMUST00000038495.3
 Crp
C-reactive protein, pentraxin-related
chr9_+_99629496 0.401 ENSMUST00000131095.1
ENSMUST00000078367.5
ENSMUST00000112885.2
 Dzip1l


DAZ interacting protein 1-like


chr16_+_20651652 0.400 ENSMUST00000007212.8
 Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.3 1.5 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.2 1.3 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.3 0.9 GO:0003195 tricuspid valve formation(GO:0003195)
0.2 0.9 GO:0050748 negative regulation of lipoprotein metabolic process(GO:0050748)
0.3 0.8 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016) regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.1 0.7 GO:0015705 iodide transport(GO:0015705)
0.1 0.6 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.2 0.5 GO:0030210 heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.2 0.5 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.5 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.4 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.4 GO:0055118 negative regulation of cardiac muscle contraction(GO:0055118)
0.1 0.4 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.3 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.3 GO:0019369 drug metabolic process(GO:0017144) arachidonic acid metabolic process(GO:0019369)
0.1 0.2 GO:1904192 regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142) cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.0 0.2 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.9 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.9 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.4 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.1 0.3 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.3 1.3 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.3 0.9 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.9 GO:0016209 antioxidant activity(GO:0016209)
0.2 0.7 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.0 0.6 GO:0004497 monooxygenase activity(GO:0004497)
0.1 0.5 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.0 0.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 0.4 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.3 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.2 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.2 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0005243 gap junction channel activity(GO:0005243)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.8 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.7 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.4 PID_IL6_7_PATHWAY IL6-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 0.9 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.5 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 0.4 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.1 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly