ISMARA results: Zic4

Motif ID: Zic4

Z-value: 0.662

Transcription factors associated with Zic4:

Gene Symbol	Entrez ID	Gene Name
Zic4	ENSMUSG00000036972.8	Zic4

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Zic4	mm10_v2_chr9_+_91368970_91369073	-0.40	1.0e-01	Click!

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Showing 1 to 20 of 181 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr6_+_141524379	2.183	ENSMUST00000032362.9	Slco1c1	solute carrier organic anion transporter family, member 1c1
chr2_+_180499893	2.053	ENSMUST00000029084.2	Ntsr1	neurotensin receptor 1
chr4_+_152338619	1.707	ENSMUST00000030775.5 ENSMUST00000164662.1	Chd5	chromodomain helicase DNA binding protein 5
chr4_+_152338887	1.591	ENSMUST00000005175.4	Chd5	chromodomain helicase DNA binding protein 5
chr4_-_64046925	1.447	ENSMUST00000107377.3	Tnc	tenascin C
chr4_+_141368116	1.218	ENSMUST00000006380.4	Fam131c	family with sequence similarity 131, member C
chr9_-_29412204	1.180	ENSMUST00000115237.1	Ntm	neurotrimin
chr17_+_46297917	1.165	ENSMUST00000166617.1 ENSMUST00000170271.1	Dlk2	delta-like 2 homolog (Drosophila)
chr10_+_106470281	1.138	ENSMUST00000029404.9 ENSMUST00000169303.1	Ppfia2	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr19_-_57008187	1.115	ENSMUST00000118800.1 ENSMUST00000111584.2 ENSMUST00000122359.1 ENSMUST00000148049.1	Afap1l2	actin filament associated protein 1-like 2
chr11_+_24076529	1.068	ENSMUST00000148087.1	Gm12063	predicted gene 12063
chr6_-_59426279	1.016	ENSMUST00000051065.4	Gprin3	GPRIN family member 3
chr1_-_43163891	1.012	ENSMUST00000008280.7	Fhl2	four and a half LIM domains 2
chr14_-_64455903	0.917	ENSMUST00000067927.7	Msra	methionine sulfoxide reductase A
chr19_+_4099998	0.904	ENSMUST00000049658.7	Pitpnm1	phosphatidylinositol transfer protein, membrane-associated 1
chr5_-_139325616	0.864	ENSMUST00000110865.1	Adap1	ArfGAP with dual PH domains 1
chr4_+_104367549	0.813	ENSMUST00000106830.2	Dab1	disabled 1
chr7_-_16476765	0.766	ENSMUST00000002053.8	Npas1	neuronal PAS domain protein 1
chr7_-_47133395	0.763	ENSMUST00000107617.1	Ptpn5	protein tyrosine phosphatase, non-receptor type 5
chr7_-_47133684	0.761	ENSMUST00000102626.1	Ptpn5	protein tyrosine phosphatase, non-receptor type 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 70 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	3.3	GO:0035093	spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.2	2.2	GO:0015721	bile acid and bile salt transport(GO:0015721)
0.5	2.1	GO:0090238	positive regulation of arachidonic acid secretion(GO:0090238)
0.0	1.7	GO:0048713	regulation of oligodendrocyte differentiation(GO:0048713)
0.3	1.5	GO:2001025	positive regulation of response to drug(GO:2001025)
0.4	1.4	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.1	1.2	GO:0045598	regulation of fat cell differentiation(GO:0045598)
0.0	1.2	GO:0008584	male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0	1.1	GO:0032757	positive regulation of interleukin-8 production(GO:0032757)
0.3	1.0	GO:0030827	negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.3	1.0	GO:0017055	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.1	1.0	GO:0060347	heart trabecula formation(GO:0060347)
0.3	0.8	GO:0021577	hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1	0.8	GO:0032811	negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.0	0.8	GO:0042711	maternal behavior(GO:0042711)
0.1	0.7	GO:1990034	calcium ion export from cell(GO:1990034)
0.0	0.7	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.7	GO:0015914	phospholipid transport(GO:0015914)
0.0	0.6	GO:1903861	positive regulation of dendrite extension(GO:1903861)
0.1	0.5	GO:1903347	negative regulation of bicellular tight junction assembly(GO:1903347)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 28 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.6	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.5	2.1	GO:0032280	symmetric synapse(GO:0032280)
0.0	1.7	GO:0031225	anchored component of membrane(GO:0031225)
0.1	1.5	GO:1990635	proximal dendrite(GO:1990635)
0.1	1.4	GO:0005614	interstitial matrix(GO:0005614)
0.1	1.0	GO:0044327	dendritic spine head(GO:0044327)
0.0	1.0	GO:0031430	M band(GO:0031430)
0.2	0.8	GO:0038039	G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0	0.8	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.2	0.7	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.5	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.5	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.4	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.4	GO:0032593	insulin-responsive compartment(GO:0032593)
0.1	0.3	GO:0033010	paranodal junction(GO:0033010)
0.0	0.3	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.2	GO:0031084	BLOC-2 complex(GO:0031084)
0.0	0.2	GO:1903440	calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0	0.2	GO:0002139	stereocilia coupling link(GO:0002139)
0.0	0.2	GO:0043083	synaptic cleft(GO:0043083)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 40 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	3.3	GO:0061628	H3K27me3 modified histone binding(GO:0061628)
0.5	2.2	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.1	2.1	GO:0008188	neuropeptide receptor activity(GO:0008188)
0.0	2.1	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.3	1.7	GO:0045545	syndecan binding(GO:0045545)
0.0	1.5	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.1	1.1	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.3	1.0	GO:0002153	steroid receptor RNA activator RNA binding(GO:0002153)
0.3	0.9	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1	0.9	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.1	0.8	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.1	0.8	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.7	GO:0042169	SH2 domain binding(GO:0042169)
0.1	0.5	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0	0.5	GO:0048273	mitogen-activated protein kinase p38 binding(GO:0048273)
0.0	0.5	GO:0038191	neuropilin binding(GO:0038191)
0.1	0.4	GO:0001225	RNA polymerase II transcription coactivator binding(GO:0001225)
0.1	0.4	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0	0.4	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.4	GO:0015211	purine nucleoside transmembrane transporter activity(GO:0015211)

Gene overrepresentation in C2:CP category:

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Showing 1 to 11 of 11 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	PID_INTEGRIN_A9B1_PATHWAY	Alpha9 beta1 integrin signaling events
0.0	1.3	PID_HDAC_CLASSIII_PATHWAY	Signaling events mediated by HDAC Class III
0.0	1.0	NABA_BASEMENT_MEMBRANES	Genes encoding structural components of basement membranes
0.0	1.0	PID_RXR_VDR_PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.9	PID_ARF6_PATHWAY	Arf6 signaling events
0.0	0.8	PID_LIS1_PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.7	PID_FRA_PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	0.6	PID_INSULIN_GLUCOSE_PATHWAY	Insulin-mediated glucose transport
0.0	0.5	PID_THROMBIN_PAR4_PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.5	NABA_COLLAGENS	Genes encoding collagen proteins
0.0	0.4	PID_SYNDECAN_3_PATHWAY	Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 16 of 16 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.2	REACTOME_TRANSPORT_OF_ORGANIC_ANIONS	Genes involved in Transport of organic anions
0.0	2.0	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.0	1.2	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	1.0	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.9	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	0.9	REACTOME_NCAM1_INTERACTIONS	Genes involved in NCAM1 interactions
0.1	0.8	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1	0.7	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.6	REACTOME_HS_GAG_DEGRADATION	Genes involved in HS-GAG degradation
0.1	0.5	REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.5	REACTOME_PLATELET_SENSITIZATION_BY_LDL	Genes involved in Platelet sensitization by LDL
0.0	0.5	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.4	REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.4	REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.3	REACTOME_GABA_A_RECEPTOR_ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.2	REACTOME_P2Y_RECEPTORS	Genes involved in P2Y receptors