Motif ID: Plagl1

Z-value: 0.517


Transcription factors associated with Plagl1:

Gene SymbolEntrez IDGene Name
Plagl1 ENSMUSG00000019817.12 Plagl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plagl1mm10_v2_chr10_+_13090788_13090843-0.681.8e-03Click!


Activity profile for motif Plagl1.

activity profile for motif Plagl1


Sorted Z-values histogram for motif Plagl1

Sorted Z-values for motif Plagl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plagl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 100 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_46297406 1.446 ENSMUST00000061722.6
ENSMUST00000166280.1
Dlk2

delta-like 2 homolog (Drosophila)

chr4_+_152338619 1.402 ENSMUST00000030775.5
ENSMUST00000164662.1
Chd5

chromodomain helicase DNA binding protein 5

chr2_-_104257400 1.213 ENSMUST00000141159.1
D430041D05Rik
RIKEN cDNA D430041D05 gene
chr5_-_139130159 1.144 ENSMUST00000129851.1
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr6_-_91807424 1.034 ENSMUST00000162300.1
Grip2
glutamate receptor interacting protein 2
chr17_+_46297917 0.999 ENSMUST00000166617.1
ENSMUST00000170271.1
Dlk2

delta-like 2 homolog (Drosophila)

chr6_-_91807318 0.881 ENSMUST00000159684.1
Grip2
glutamate receptor interacting protein 2
chr10_-_81482655 0.856 ENSMUST00000120508.1
ENSMUST00000118763.1
Celf5

CUGBP, Elav-like family member 5

chr4_-_22488296 0.753 ENSMUST00000178174.1
Pou3f2
POU domain, class 3, transcription factor 2
chr15_-_43869993 0.726 ENSMUST00000067469.4
Tmem74
transmembrane protein 74
chr3_+_26331150 0.725 ENSMUST00000099182.2
A830092H15Rik
RIKEN cDNA A830092H15 gene
chr17_-_24644933 0.711 ENSMUST00000019684.5
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr19_+_6497772 0.671 ENSMUST00000113458.1
ENSMUST00000113459.1
Nrxn2

neurexin II

chr2_-_65567465 0.657 ENSMUST00000066432.5
Scn3a
sodium channel, voltage-gated, type III, alpha
chr18_-_38601268 0.637 ENSMUST00000025295.6
Spry4
sprouty homolog 4 (Drosophila)
chr2_-_39190687 0.614 ENSMUST00000142872.1
ENSMUST00000038874.5
Scai

suppressor of cancer cell invasion

chr11_-_120047144 0.578 ENSMUST00000103020.1
Aatk
apoptosis-associated tyrosine kinase
chr2_-_65567505 0.561 ENSMUST00000100069.2
Scn3a
sodium channel, voltage-gated, type III, alpha
chr11_+_70018421 0.538 ENSMUST00000108588.1
Dlg4
discs, large homolog 4 (Drosophila)
chr19_+_45047557 0.441 ENSMUST00000062213.5
ENSMUST00000111954.4
ENSMUST00000084493.6
Sfxn3


sideroflexin 3



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 1.9 GO:0014824 artery smooth muscle contraction(GO:0014824)
0.2 1.4 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.2 1.2 GO:0046684 response to pyrethroid(GO:0046684)
0.1 1.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.3 0.8 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.1 0.8 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.8 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.0 0.7 GO:0042297 vocal learning(GO:0042297) imitative learning(GO:0098596)
0.1 0.6 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.6 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.6 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.5 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.1 0.4 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 0.4 GO:0072318 clathrin coat disassembly(GO:0072318)
0.0 0.4 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.0 0.4 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 0.3 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.3 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0005605 basal lamina(GO:0005605)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0035254 glutamate receptor binding(GO:0035254)
0.4 1.4 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.1 1.2 GO:0031402 sodium ion binding(GO:0031402)
0.1 1.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.3 0.8 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.1 0.8 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.8 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.7 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.5 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.4 GO:0071253 connexin binding(GO:0071253)
0.1 0.3 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.3 GO:0070905 serine binding(GO:0070905)
0.0 0.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.2 GO:0016015 morphogen activity(GO:0016015)
0.1 0.2 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 0.2 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0 0.2 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.2 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.2 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.4 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.4 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 0.4 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.3 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 0.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.2 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes