Motif ID: Klf16_Sp8

Z-value: 1.487

Transcription factors associated with Klf16_Sp8:

Gene SymbolEntrez IDGene Name
Klf16 ENSMUSG00000035397.8 Klf16
Sp8 ENSMUSG00000048562.6 Sp8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf16mm10_v2_chr10_-_80577285_80577327-0.781.2e-04Click!
Sp8mm10_v2_chr12_+_118846329_1188463290.282.7e-01Click!


Activity profile for motif Klf16_Sp8.

activity profile for motif Klf16_Sp8


Sorted Z-values histogram for motif Klf16_Sp8

Sorted Z-values for motif Klf16_Sp8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf16_Sp8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_45742873 5.177 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr7_-_127026479 4.801 ENSMUST00000032916.4
 Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr12_+_17690793 4.132 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr7_-_38107490 4.022 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr7_-_110061319 4.014 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr7_-_4752972 3.956 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr10_-_80329426 3.943 ENSMUST00000020340.8
 Pcsk4
proprotein convertase subtilisin/kexin type 4
chr4_-_55532453 3.896 ENSMUST00000132746.1
ENSMUST00000107619.2
 Klf4

Kruppel-like factor 4 (gut)

chr9_-_119578981 3.757 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr7_-_45211877 3.537 ENSMUST00000033057.7
 Dkkl1
dickkopf-like 1
chr4_-_117133953 3.451 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr7_+_45216671 3.274 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr2_+_164562579 3.269 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr5_-_144358103 3.201 ENSMUST00000055190.7
 Baiap2l1
BAI1-associated protein 2-like 1
chr12_+_108334341 3.177 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr12_+_103314944 3.150 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr17_+_25717171 3.143 ENSMUST00000172002.1
 Gng13
guanine nucleotide binding protein (G protein), gamma 13
chr5_+_139543889 3.024 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr11_+_69935796 3.021 ENSMUST00000018698.5
 Ybx2
Y box protein 2
chr18_+_49979514 2.995 ENSMUST00000179937.1
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.7 GO:0006270 DNA replication initiation(GO:0006270)
0.4 9.2 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.3 8.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 8.6 GO:0048255 mRNA stabilization(GO:0048255)
1.2 8.2 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.3 7.9 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.3 6.3 GO:0030903 notochord development(GO:0030903)
0.1 6.0 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.3 5.5 GO:0044458 motile cilium assembly(GO:0044458)
1.8 5.3 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
1.6 4.9 GO:0030421 defecation(GO:0030421)
0.4 4.9 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.3 4.9 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
0.3 4.8 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.2 4.7 GO:0051764 actin crosslink formation(GO:0051764)
0.1 4.7 GO:0006284 base-excision repair(GO:0006284)
0.6 4.6 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.5 4.6 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.2 4.6 GO:0048240 sperm capacitation(GO:0048240)
0.2 4.6 GO:0034508 centromere complex assembly(GO:0034508)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 366 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 30.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 20.0 GO:0005615 extracellular space(GO:0005615)
0.2 16.1 GO:0005844 polysome(GO:0005844)
0.1 15.4 GO:0016607 nuclear speck(GO:0016607)
0.1 13.6 GO:0022626 cytosolic ribosome(GO:0022626)
0.2 12.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 8.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 7.9 GO:0005581 collagen trimer(GO:0005581)
0.2 7.8 GO:0000791 euchromatin(GO:0000791)
0.0 7.8 GO:0000785 chromatin(GO:0000785)
0.1 7.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 5.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.6 5.3 GO:0000796 condensin complex(GO:0000796)
0.1 5.3 GO:0015934 large ribosomal subunit(GO:0015934)
0.7 5.2 GO:0042627 chylomicron(GO:0042627)
0.3 4.9 GO:0030061 mitochondrial crista(GO:0030061)
0.0 4.7 GO:0005681 spliceosomal complex(GO:0005681)
0.0 4.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.5 4.4 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.3 4.4 GO:0031011 Ino80 complex(GO:0031011)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 601 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 34.7 GO:0001159 core promoter proximal region DNA binding(GO:0001159)
0.1 19.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 16.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 14.9 GO:0042393 histone binding(GO:0042393)
0.2 10.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 10.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 8.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 8.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.6 7.8 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 7.6 GO:0008083 growth factor activity(GO:0008083)
0.1 7.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 7.2 GO:0001047 core promoter binding(GO:0001047)
0.0 7.1 GO:0003677 DNA binding(GO:0003677)
0.2 7.0 GO:0070888 E-box binding(GO:0070888)
0.1 6.8 GO:0005179 hormone activity(GO:0005179)
1.2 6.2 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.3 5.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 5.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 5.7 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 5.6 GO:0045182 translation regulator activity(GO:0045182)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 12.9 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.1 12.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 12.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.8 11.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 10.6 PID_PLK1_PATHWAY PLK1 signaling events
0.3 9.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 9.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 8.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 6.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 6.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 5.8 PID_E2F_PATHWAY E2F transcription factor network
0.1 5.7 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 4.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 3.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.4 PID_FGF_PATHWAY FGF signaling pathway
0.1 3.2 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.1 3.0 PID_BARD1_PATHWAY BARD1 signaling events
0.1 3.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 171 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.0 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.2 13.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 11.1 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.5 10.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 9.4 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 9.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 8.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 8.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 7.4 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 7.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 6.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 6.3 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.1 6.3 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.4 6.2 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.7 6.1 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.4 6.0 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 5.8 REACTOME_RNA_POL_I_TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.2 5.2 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 5.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 4.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.