Motif ID: Klf4_Sp3

Z-value: 1.655

Transcription factors associated with Klf4_Sp3:

Gene SymbolEntrez IDGene Name
Klf4 ENSMUSG00000003032.8 Klf4
Sp3 ENSMUSG00000027109.10 Sp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp3mm10_v2_chr2_-_72980402_72980471-0.701.3e-03Click!
Klf4mm10_v2_chr4_-_55532453_555324850.282.5e-01Click!


Activity profile for motif Klf4_Sp3.

activity profile for motif Klf4_Sp3


Sorted Z-values histogram for motif Klf4_Sp3

Sorted Z-values for motif Klf4_Sp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf4_Sp3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_29289300 8.245 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr10_-_127534540 8.173 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr13_+_48261427 5.962 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr8_+_87473116 5.759 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr12_+_17690793 5.697 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr17_-_70851189 5.578 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr4_+_124986430 4.926 ENSMUST00000030687.7
 Rspo1
R-spondin homolog (Xenopus laevis)
chr10_+_108332173 4.884 ENSMUST00000095313.3
 Pawr
PRKC, apoptosis, WT1, regulator
chr7_-_38107490 4.819 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr6_-_115994953 4.747 ENSMUST00000015511.8
 Plxnd1
plexin D1
chr1_-_175692624 4.744 ENSMUST00000027809.7
 Opn3
opsin 3
chr7_-_143460989 4.626 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr6_-_72958097 4.462 ENSMUST00000114049.1
 Tmsb10
thymosin, beta 10
chr5_+_127241807 4.351 ENSMUST00000119026.1
 Tmem132c
transmembrane protein 132C
chr3_-_8667033 4.218 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr11_-_76399107 4.190 ENSMUST00000021204.3
 Nxn
nucleoredoxin
chr8_+_105518736 4.180 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr12_+_110279228 4.133 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr4_-_117133953 4.123 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr7_-_34812677 3.903 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,151 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 14.9 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.3 11.1 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.5 10.8 GO:0044458 motile cilium assembly(GO:0044458)
0.5 10.2 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.2 9.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.3 9.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 9.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.2 9.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 9.0 GO:0006270 DNA replication initiation(GO:0006270)
0.2 8.8 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.3 8.7 GO:0006783 heme biosynthetic process(GO:0006783)
1.7 8.5 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.2 8.5 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.7 8.4 GO:0002176 male germ cell proliferation(GO:0002176)
0.2 7.7 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.2 7.1 GO:0035690 cellular response to drug(GO:0035690)
1.7 6.9 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
2.3 6.8 GO:1904274 tricellular tight junction assembly(GO:1904274)
1.7 6.8 GO:0030091 protein repair(GO:0030091)
0.5 6.8 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 407 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 61.6 GO:0005739 mitochondrion(GO:0005739)
0.0 59.4 GO:0070062 extracellular exosome(GO:0070062)
0.1 30.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 21.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 14.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 14.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 12.1 GO:0005576 extracellular region(GO:0005576)
0.2 12.0 GO:0070469 respiratory chain(GO:0070469)
0.4 11.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 11.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 11.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.3 8.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 7.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.7 7.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 7.4 GO:0072562 blood microparticle(GO:0072562)
0.1 7.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.5 7.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 7.0 GO:0000124 SAGA complex(GO:0000124)
1.1 6.8 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.6 6.7 GO:0005642 annulate lamellae(GO:0005642)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 644 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 51.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 19.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.4 15.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.3 14.3 GO:0019003 GDP binding(GO:0019003)
0.2 13.8 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.1 12.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.3 12.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 12.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 10.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.8 10.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
1.9 9.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.3 8.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 8.3 GO:0002039 p53 binding(GO:0002039)
0.4 8.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.5 8.0 GO:0019215 intermediate filament binding(GO:0019215)
0.5 7.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 7.4 GO:0008083 growth factor activity(GO:0008083)
0.4 7.3 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.3 7.1 GO:0003785 actin monomer binding(GO:0003785)
1.4 7.0 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 25.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 22.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.2 18.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.5 15.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 14.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 13.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.9 12.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3 9.6 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.3 9.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 9.4 NABA_COLLAGENS Genes encoding collagen proteins
0.4 9.3 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 9.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.2 9.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 8.6 PID_ALK1_PATHWAY ALK1 signaling events
0.2 8.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 8.4 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2 8.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 8.0 PID_P73PATHWAY p73 transcription factor network
0.2 7.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 7.3 PID_RAC1_PATHWAY RAC1 signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 174 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 35.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.4 32.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 17.1 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.3 17.0 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.4 14.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.7 14.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.4 14.3 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.6 13.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 13.2 REACTOME_MITOTIC_M_M_G1_PHASES Genes involved in Mitotic M-M/G1 phases
0.3 12.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 12.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.5 11.5 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.4 10.2 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 10.2 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 9.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 9.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.6 9.3 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.6 9.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 8.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.5 8.6 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription