Motif ID: Msx2_Hoxd4

Z-value: 0.912

Transcription factors associated with Msx2_Hoxd4:

Gene SymbolEntrez IDGene Name
Msx2 ENSMUSG00000021469.8 Msx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_53473074-0.494.1e-02Click!


Activity profile for motif Msx2_Hoxd4.

activity profile for motif Msx2_Hoxd4


Sorted Z-values histogram for motif Msx2_Hoxd4

Sorted Z-values for motif Msx2_Hoxd4



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx2_Hoxd4

PNG image of the network

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Top targets:


Showing 1 to 20 of 146 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62766153 5.571 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_+_21111452 4.416 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr1_+_159737510 3.538 ENSMUST00000111669.3
 Tnr
tenascin R
chr2_+_4017727 3.199 ENSMUST00000177457.1
 Frmd4a
FERM domain containing 4A
chr2_-_63184253 2.379 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr3_+_62419668 2.122 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr14_-_88471396 1.879 ENSMUST00000061628.5
 Pcdh20
protocadherin 20
chr6_-_136171722 1.852 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr5_-_62765618 1.816 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr12_+_74297474 1.809 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chrX_+_101640056 1.699 ENSMUST00000119299.1
ENSMUST00000044475.4
 Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chr15_+_92597104 1.568 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr7_-_73537621 1.558 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chr1_+_165788681 1.544 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr3_-_85741389 1.449 ENSMUST00000094148.4
 Fam160a1
family with sequence similarity 160, member A1
chr1_-_163725123 1.411 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr11_+_103133303 1.382 ENSMUST00000107037.1
 Hexim2
hexamethylene bis-acetamide inducible 2
chr10_+_39612934 1.327 ENSMUST00000019987.6
 Traf3ip2
TRAF3 interacting protein 2
chr1_+_165788746 1.317 ENSMUST00000161559.2
 Cd247
CD247 antigen
chr3_-_146495115 1.282 ENSMUST00000093951.2
 Spata1
spermatogenesis associated 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 3.7 GO:0051291 protein heterooligomerization(GO:0051291)
0.9 3.5 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 3.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 2.9 GO:0070207 protein homotrimerization(GO:0070207)
0.1 2.6 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 2.5 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 2.3 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 2.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.5 1.9 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 1.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.6 1.7 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 1.6 GO:0007416 synapse assembly(GO:0007416)
0.3 1.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 1.4 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 1.3 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 1.2 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.4 1.1 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.3 1.0 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.3 1.0 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 3.5 GO:0072534 perineuronal net(GO:0072534)
0.0 3.0 GO:0005923 bicellular tight junction(GO:0005923)
0.7 2.9 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 1.9 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.8 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.6 GO:0042588 zymogen granule(GO:0042588)
0.1 1.1 GO:0044327 dendritic spine head(GO:0044327)
0.1 1.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 0.8 GO:0031673 H zone(GO:0031673)
0.0 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 0.6 GO:0055087 Ski complex(GO:0055087)
0.0 0.5 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.5 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.0 0.4 GO:0000346 transcription export complex(GO:0000346)
0.1 0.2 GO:0031251 PAN complex(GO:0031251)
0.0 0.2 GO:0031523 Myb complex(GO:0031523)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 6.8 GO:0005509 calcium ion binding(GO:0005509)
0.0 3.8 GO:0008017 microtubule binding(GO:0008017)
0.2 3.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.2 3.5 GO:0046625 sphingolipid binding(GO:0046625)
0.0 3.2 GO:0030674 protein binding, bridging(GO:0030674)
0.0 2.9 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 2.8 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.3 2.6 GO:0097322 7SK snRNA binding(GO:0097322)
0.2 1.9 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.6 1.7 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 1.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 1.0 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 1.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 1.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.0 GO:0008276 protein methyltransferase activity(GO:0008276)
0.2 0.9 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.9 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 4.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.1 PID_CDC42_PATHWAY CDC42 signaling events
0.1 1.0 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.7 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.7 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.5 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.5 2.9 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.5 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 1.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.8 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins