Motif ID: Obox6_Obox5

Z-value: 0.713

Transcription factors associated with Obox6_Obox5:

Gene SymbolEntrez IDGene Name
Obox5 ENSMUSG00000074366.3 Obox5
Obox6 ENSMUSG00000041583.7 Obox6



Activity profile for motif Obox6_Obox5.

activity profile for motif Obox6_Obox5


Sorted Z-values histogram for motif Obox6_Obox5

Sorted Z-values for motif Obox6_Obox5



Network of associatons between targets according to the STRING database.



First level regulatory network of Obox6_Obox5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_4752972 2.183 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr14_-_20181773 2.023 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr7_-_103843154 1.722 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr9_-_37433138 1.676 ENSMUST00000115038.1
 Robo3
roundabout homolog 3 (Drosophila)
chr7_+_16781341 1.653 ENSMUST00000108496.2
 Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
chr6_-_23248264 1.612 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr2_+_164562579 1.551 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr10_+_94198955 1.491 ENSMUST00000020209.9
ENSMUST00000179990.1
 Ndufa12

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12

chr7_+_88430257 1.459 ENSMUST00000107256.2
 Rab38
RAB38, member of RAS oncogene family
chrY_+_1010543 1.326 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr3_-_25212720 1.034 ENSMUST00000091289.3
 Gm10259
predicted pseudogene 10259
chr9_+_51621425 1.031 ENSMUST00000089534.4
 Gm7293
predicted gene 7293
chr13_+_21811737 1.017 ENSMUST00000104941.2
 Hist1h4m
histone cluster 1, H4m
chr3_-_73708399 0.968 ENSMUST00000029367.5
 Bche
butyrylcholinesterase
chr9_+_50617516 0.963 ENSMUST00000141366.1
 Pih1d2
PIH1 domain containing 2
chr19_+_53140430 0.960 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr16_-_33380717 0.958 ENSMUST00000180923.1
 1700007L15Rik
RIKEN cDNA 1700007L15 gene
chr16_-_23127702 0.943 ENSMUST00000115338.1
ENSMUST00000115337.1
ENSMUST00000023598.8
 Rfc4


replication factor C (activator 1) 4


chr13_-_98492001 0.934 ENSMUST00000170205.1
 Gm10320
predicted pseudogene 10320
chr14_+_27039001 0.924 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.0 GO:0030322 stabilization of membrane potential(GO:0030322)
0.4 1.7 GO:0015825 L-serine transport(GO:0015825)
0.3 1.7 GO:0015671 oxygen transport(GO:0015671)
0.3 1.7 GO:0061642 chemoattraction of axon(GO:0061642)
0.1 1.7 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 1.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.3 1.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 1.5 GO:0060155 platelet dense granule organization(GO:0060155)
0.3 1.5 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.0 1.5 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 1.1 GO:0006413 translational initiation(GO:0006413)
0.5 1.0 GO:0014016 neuroblast differentiation(GO:0014016)
0.3 0.9 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.3 0.9 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.3 0.9 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.1 0.9 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 0.9 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.8 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 2.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 1.7 GO:0005833 hemoglobin complex(GO:0005833)
0.5 1.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.4 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 0.9 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.2 0.9 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.9 GO:0031526 brush border membrane(GO:0031526)
0.1 0.7 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.7 GO:0000124 SAGA complex(GO:0000124)
0.0 0.7 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.7 GO:0000786 nucleosome(GO:0000786)
0.2 0.6 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.2 0.6 GO:0005584 collagen type I trimer(GO:0005584)
0.1 0.6 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 0.6 GO:0043256 laminin complex(GO:0043256)
0.1 0.6 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0042393 histone binding(GO:0042393)
0.2 2.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 2.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 1.7 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 1.7 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.3 1.6 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.5 1.5 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.0 1.5 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 1.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.3 1.0 GO:0003998 acylphosphatase activity(GO:0003998)
0.2 1.0 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.0 1.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.3 0.9 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 0.9 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.3 0.9 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 0.9 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.9 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.5 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 1.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.4 PID_FGF_PATHWAY FGF signaling pathway
0.1 0.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.5 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.1 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 2.7 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 2.1 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 1.7 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.3 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.0 1.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 0.9 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 0.9 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.7 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 0.6 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 0.6 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.6 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 0.5 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.5 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.5 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.5 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway