Motif ID: Hsfy2

Z-value: 0.946


Transcription factors associated with Hsfy2:

Gene SymbolEntrez IDGene Name
Hsfy2 ENSMUSG00000045336.4 Hsfy2



Activity profile for motif Hsfy2.

activity profile for motif Hsfy2


Sorted Z-values histogram for motif Hsfy2

Sorted Z-values for motif Hsfy2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsfy2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_39846958 2.564 ENSMUST00000182010.1
 Gm26924
predicted gene, 26924
chr17_+_43953191 2.433 ENSMUST00000044792.4
 Rcan2
regulator of calcineurin 2
chr11_+_32205411 2.268 ENSMUST00000039601.3
ENSMUST00000149043.1
 Snrnp25

small nuclear ribonucleoprotein 25 (U11/U12)

chr1_+_45311538 2.120 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr2_-_80447625 2.037 ENSMUST00000028389.3
 Frzb
frizzled-related protein
chr9_-_37613715 2.034 ENSMUST00000002013.9
 Spa17
sperm autoantigenic protein 17
chr6_+_7555053 1.957 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr2_+_152847993 1.850 ENSMUST00000028969.8
 Tpx2
TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr9_+_44134562 1.818 ENSMUST00000034650.8
ENSMUST00000098852.2
 Mcam

melanoma cell adhesion molecule

chr5_-_149051604 1.810 ENSMUST00000093196.4
 Hmgb1
high mobility group box 1
chr9_-_32344237 1.807 ENSMUST00000034533.5
 Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr12_+_55598917 1.708 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr4_+_105157339 1.657 ENSMUST00000064139.7
 Ppap2b
phosphatidic acid phosphatase type 2B
chr2_+_152847961 1.649 ENSMUST00000164120.1
ENSMUST00000178997.1
ENSMUST00000109816.1
 Tpx2


TPX2, microtubule-associated protein homolog (Xenopus laevis)


chr13_+_51645232 1.636 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr3_+_85915722 1.632 ENSMUST00000054148.7
 Gm9790
predicted gene 9790
chr2_-_151980135 1.620 ENSMUST00000062047.5
 Fam110a
family with sequence similarity 110, member A
chr6_+_56017489 1.572 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr3_+_107896247 1.554 ENSMUST00000169365.1
 Gstm5
glutathione S-transferase, mu 5
chr17_+_50698525 1.465 ENSMUST00000061681.7
 Gm7334
predicted gene 7334

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0008380 RNA splicing(GO:0008380)
0.1 4.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.1 2.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 2.4 GO:0070884 short-term memory(GO:0007614) regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 2.3 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.5 2.2 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.4 2.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.7 2.0 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.7 2.0 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.1 2.0 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.3 1.9 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.1 1.9 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.6 1.8 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.4 1.8 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.1 1.8 GO:0003334 keratinocyte development(GO:0003334)
0.0 1.8 GO:0042476 odontogenesis(GO:0042476)
0.0 1.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 1.6 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.0 1.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.1 1.5 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.3 GO:0005818 aster(GO:0005818)
0.1 4.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 3.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 3.1 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 3.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 2.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 2.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.8 GO:0030315 T-tubule(GO:0030315)
0.1 1.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 1.6 GO:0097225 sperm midpiece(GO:0097225)
0.1 1.5 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 1.4 GO:0097526 spliceosomal tri-snRNP complex(GO:0097526)
0.3 1.3 GO:0005594 collagen type IX trimer(GO:0005594)
0.4 1.2 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 1.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.2 GO:0000922 spindle pole(GO:0000922)
0.4 1.1 GO:0000801 central element(GO:0000801)
0.1 1.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 3.5 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.1 2.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 2.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.3 2.1 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 2.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 2.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 2.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 2.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.6 1.8 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.4 1.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.4 1.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 1.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 1.6 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.6 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 1.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 1.4 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.2 1.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 1.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 1.3 GO:0008494 translation activator activity(GO:0008494)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 3.4 NABA_COLLAGENS Genes encoding collagen proteins
0.0 3.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.2 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.9 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.8 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.1 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.1 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.1 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 1.0 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.0 0.9 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 0.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.8 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 3.9 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.2 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.8 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.5 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 1.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 1.4 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.4 REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.0 1.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.2 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.1 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.1 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.0 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.0 0.9 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 0.8 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs