Motif ID: Snai1_Zeb1_Snai2

Z-value: 1.762

Transcription factors associated with Snai1_Zeb1_Snai2:

Gene SymbolEntrez IDGene Name
Snai1 ENSMUSG00000042821.7 Snai1
Snai2 ENSMUSG00000022676.6 Snai2
Zeb1 ENSMUSG00000024238.7 Zeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zeb1mm10_v2_chr18_+_5591860_5591902-0.446.8e-02Click!
Snai2mm10_v2_chr16_+_14705832_14705858-0.155.7e-01Click!
Snai1mm10_v2_chr2_+_167538192_167538210-0.136.2e-01Click!


Activity profile for motif Snai1_Zeb1_Snai2.

activity profile for motif Snai1_Zeb1_Snai2


Sorted Z-values histogram for motif Snai1_Zeb1_Snai2

Sorted Z-values for motif Snai1_Zeb1_Snai2



Network of associatons between targets according to the STRING database.



First level regulatory network of Snai1_Zeb1_Snai2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_57907587 4.410 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr12_+_82616885 4.380 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr11_-_67922136 4.168 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr4_+_85205417 4.038 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr15_-_66831625 3.988 ENSMUST00000164163.1
 Sla
src-like adaptor
chr1_-_134234492 3.921 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor
chr12_-_4592927 3.705 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr14_+_101729907 2.941 ENSMUST00000100337.3
 Lmo7
LIM domain only 7
chr11_+_103171081 2.880 ENSMUST00000042286.5
 Fmnl1
formin-like 1
chr2_-_32312162 2.777 ENSMUST00000155269.1
 Dnm1
dynamin 1
chr19_-_57314896 2.744 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr16_+_18776839 2.738 ENSMUST00000043577.1
 Cldn5
claudin 5
chr5_-_139130159 2.637 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr5_-_147076482 2.557 ENSMUST00000016664.7
 Lnx2
ligand of numb-protein X 2
chr18_-_61911783 2.520 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr7_-_27446599 2.458 ENSMUST00000011895.7
 Sptbn4
spectrin beta, non-erythrocytic 4
chr5_+_35056813 2.454 ENSMUST00000101298.2
ENSMUST00000114270.1
ENSMUST00000133381.1
 Dok7


docking protein 7


chr2_-_65022740 2.428 ENSMUST00000028252.7
 Grb14
growth factor receptor bound protein 14
chr8_+_70493156 2.387 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr5_+_37028329 2.366 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 768 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.0 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
1.9 5.6 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242)
0.2 5.5 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.7 5.2 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.3 4.8 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.1 4.3 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.3 4.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 4.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.4 3.8 GO:0071420 cellular response to histamine(GO:0071420)
0.6 3.7 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.4 3.7 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.2 3.7 GO:0001553 luteinization(GO:0001553)
0.2 3.4 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.1 3.4 GO:0008333 endosome to lysosome transport(GO:0008333)
0.7 3.0 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.5 3.0 GO:0032796 uropod organization(GO:0032796)
0.3 2.9 GO:0051014 actin filament severing(GO:0051014)
0.1 2.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.9 2.7 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.9 2.7 GO:1903538 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 273 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 9.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.3 7.0 GO:0032279 asymmetric synapse(GO:0032279)
0.2 6.6 GO:0033268 node of Ranvier(GO:0033268)
0.1 5.7 GO:0042734 presynaptic membrane(GO:0042734)
0.1 5.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 5.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 5.2 GO:0032587 ruffle membrane(GO:0032587)
0.3 5.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 4.5 GO:0005614 interstitial matrix(GO:0005614)
0.1 4.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 4.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 3.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 3.8 GO:0032426 stereocilium tip(GO:0032426)
0.2 3.7 GO:0043196 varicosity(GO:0043196)
0.0 3.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.2 3.5 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.5 3.2 GO:0008091 spectrin(GO:0008091)
0.5 3.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.2 3.2 GO:0044327 dendritic spine head(GO:0044327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 433 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 8.8 GO:0030507 spectrin binding(GO:0030507)
0.1 6.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.8 5.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.4 4.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 4.4 GO:0005158 insulin receptor binding(GO:0005158)
0.0 4.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.6 3.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.3 3.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.3 3.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 3.8 GO:0050811 GABA receptor binding(GO:0050811)
0.1 3.8 GO:0030552 cAMP binding(GO:0030552)
0.1 3.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 3.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.5 3.4 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 3.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.3 3.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.3 3.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 3.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 3.2 GO:0042805 actinin binding(GO:0042805)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 6.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 4.8 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 4.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 3.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.8 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.6 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 2.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.4 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 2.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 2.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 1.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 1.8 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 1.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 1.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.5 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.4 8.9 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.5 6.7 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.2 6.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 6.0 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.2 5.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 5.0 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 3.9 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 3.6 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 2.9 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 2.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 2.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 2.3 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 2.2 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 2.2 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.2 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.2 2.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 2.1 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 1.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events