Motif ID: Hes1

Z-value: 1.580


Transcription factors associated with Hes1:

Gene SymbolEntrez IDGene Name
Hes1 ENSMUSG00000022528.7 Hes1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes1mm10_v2_chr16_+_30065333_300653510.831.9e-05Click!


Activity profile for motif Hes1.

activity profile for motif Hes1


Sorted Z-values histogram for motif Hes1

Sorted Z-values for motif Hes1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026237 14.850 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026732 13.189 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr19_+_60144682 6.023 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr12_+_110279228 5.774 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr11_-_89302545 4.513 ENSMUST00000061728.3
 Nog
noggin
chr1_+_153652943 3.758 ENSMUST00000041776.5
 Rgs8
regulator of G-protein signaling 8
chr4_+_65124174 3.731 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr6_+_17306335 3.642 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr10_-_30842765 3.225 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr1_-_166309585 3.098 ENSMUST00000168347.1
 5330438I03Rik
RIKEN cDNA 5330438I03 gene
chrX_-_52165252 3.004 ENSMUST00000033450.2
 Gpc4
glypican 4
chr4_+_116877376 2.685 ENSMUST00000044823.3
 Zswim5
zinc finger SWIM-type containing 5
chr1_-_175692624 2.677 ENSMUST00000027809.7
 Opn3
opsin 3
chr7_-_140049083 2.596 ENSMUST00000055353.7
 Msx3
msh homeobox 3
chr4_-_58553553 2.562 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1


chr3_+_127633134 2.404 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr17_-_25797032 2.392 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr2_+_156840966 2.320 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr1_+_132316112 2.314 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2

chr6_+_120666388 2.295 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 28.0 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
1.6 6.2 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.8 5.8 GO:0046549 phenol-containing compound catabolic process(GO:0019336) retinal cone cell development(GO:0046549)
1.1 5.4 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
1.1 4.5 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
1.1 4.4 GO:0003360 brainstem development(GO:0003360)
0.3 3.8 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 3.7 GO:0051384 response to glucocorticoid(GO:0051384)
0.4 3.4 GO:0001842 neural fold formation(GO:0001842)
1.1 3.2 GO:0003195 tricuspid valve formation(GO:0003195)
0.5 3.0 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.9 2.7 GO:0018298 protein-chromophore linkage(GO:0018298)
0.7 2.7 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 2.7 GO:0035067 negative regulation of histone acetylation(GO:0035067)
0.0 2.4 GO:0007411 axon guidance(GO:0007411)
0.1 2.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 2.3 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 2.3 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.4 2.2 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.2 2.1 GO:0015721 bile acid and bile salt transport(GO:0015721)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0030139 endocytic vesicle(GO:0030139)
0.4 5.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.5 4.4 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 4.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 3.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 3.2 GO:0005768 endosome(GO:0005768)
0.0 3.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 2.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 2.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.6 2.3 GO:0090537 CERF complex(GO:0090537)
0.1 2.3 GO:0032156 septin cytoskeleton(GO:0032156)
0.4 2.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.3 2.0 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.1 1.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 1.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 1.6 GO:0000421 autophagosome membrane(GO:0000421)
0.1 1.5 GO:0005682 U5 snRNP(GO:0005682)
0.0 1.5 GO:0005790 smooth endoplasmic reticulum(GO:0005790)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 28.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.9 6.2 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
1.1 5.4 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.1 4.9 GO:0019955 cytokine binding(GO:0019955)
0.7 4.4 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 4.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 3.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 3.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.1 3.2 GO:0035939 microsatellite binding(GO:0035939)
0.1 3.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 3.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.9 GO:0019003 GDP binding(GO:0019003)
0.9 2.7 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.9 2.7 GO:0009881 photoreceptor activity(GO:0009881)
0.0 2.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.3 GO:0042393 histone binding(GO:0042393)
0.1 2.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.2 GO:0033613 activating transcription factor binding(GO:0033613)
0.5 2.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.3 2.0 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 30.5 PID_IGF1_PATHWAY IGF1 pathway
0.1 6.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.2 5.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 4.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 4.0 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.4 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.0 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 1.8 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 1.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 1.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.2 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 28.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 13.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 6.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.5 5.8 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 5.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3 5.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 4.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 3.1 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.2 2.6 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.5 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 2.5 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 2.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.2 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 2.0 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 2.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.9 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 1.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.8 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.8 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway