Motif ID: Spib
Z-value: 0.734
Transcription factors associated with Spib:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Spib | ENSMUSG00000008193.7 | Spib |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 81 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.0 | 1.8 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.3 | 1.6 | GO:0032796 | uropod organization(GO:0032796) |
| 0.0 | 1.6 | GO:0032091 | negative regulation of protein binding(GO:0032091) |
| 0.1 | 1.3 | GO:0050908 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.2 | 1.0 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.0 | 1.0 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662) |
| 0.0 | 1.0 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 1.0 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.2 | 0.9 | GO:0003105 | negative regulation of glomerular filtration(GO:0003105) |
| 0.2 | 0.8 | GO:0033087 | negative regulation of immature T cell proliferation(GO:0033087) |
| 0.1 | 0.8 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.1 | 0.8 | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) |
| 0.1 | 0.8 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 0.8 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.2 | 0.7 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 0.2 | 0.7 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 0.1 | 0.7 | GO:0035617 | stress granule disassembly(GO:0035617) plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.1 | 0.7 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.0 | 0.7 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 35 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 2.1 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 2.1 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 1.6 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 1.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 1.1 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.3 | 1.0 | GO:0099631 | postsynaptic endocytic zone cytoplasmic component(GO:0099631) |
| 0.1 | 0.9 | GO:0042581 | specific granule(GO:0042581) |
| 0.0 | 0.9 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 0.8 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.1 | 0.8 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.0 | 0.8 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.7 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.0 | 0.7 | GO:0030315 | T-tubule(GO:0030315) |
| 0.1 | 0.6 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 0.0 | 0.6 | GO:0097449 | astrocyte projection(GO:0097449) |
| 0.0 | 0.6 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 0.4 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.1 | 0.4 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.0 | 0.4 | GO:0030478 | actin cap(GO:0030478) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 49 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.4 | 1.7 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 1.6 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 1.4 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 1.3 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.1 | 1.0 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.1 | 1.0 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 1.0 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 1.0 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 1.0 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
| 0.2 | 0.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 0.8 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.8 | GO:0005179 | hormone activity(GO:0005179) |
| 0.2 | 0.7 | GO:0001639 | PLC activating G-protein coupled glutamate receptor activity(GO:0001639) A2A adenosine receptor binding(GO:0031687) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530) |
| 0.1 | 0.7 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 0.7 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.1 | 0.7 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.2 | 0.6 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 0.0 | 0.6 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.5 | GO:0050811 | GABA receptor binding(GO:0050811) |
Gene overrepresentation in C2:CP category:
Showing 1 to 16 of 16 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 2.2 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.4 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.0 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 1.0 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 0.9 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 0.9 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.8 | PID_AR_NONGENOMIC_PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 0.8 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 0.0 | 0.7 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 0.6 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.4 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.4 | SIG_CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 0.3 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.3 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.2 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 21 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 1.5 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 1.2 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 1.0 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 1.0 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.0 | 0.9 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.9 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 0.8 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 0.8 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.7 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.0 | 0.7 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 0.6 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.0 | 0.6 | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.6 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.6 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.4 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.4 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.2 | REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.0 | 0.2 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.1 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
