Motif ID: Rela_Rel_Nfkb1

Z-value: 1.289

Transcription factors associated with Rela_Rel_Nfkb1:

Gene SymbolEntrez IDGene Name
Nfkb1 ENSMUSG00000028163.11 Nfkb1
Rel ENSMUSG00000020275.8 Rel
Rela ENSMUSG00000024927.7 Rela

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb1mm10_v2_chr3_-_135608221_1356082900.841.2e-05Click!
Relamm10_v2_chr19_+_5637475_56374860.302.3e-01Click!


Activity profile for motif Rela_Rel_Nfkb1.

activity profile for motif Rela_Rel_Nfkb1


Sorted Z-values histogram for motif Rela_Rel_Nfkb1

Sorted Z-values for motif Rela_Rel_Nfkb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rela_Rel_Nfkb1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_165234689 7.242 ENSMUST00000065438.6
 Cdh22
cadherin 22
chr14_-_70642268 5.925 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr7_-_25788635 3.810 ENSMUST00000002677.4
ENSMUST00000085948.4
 Axl

AXL receptor tyrosine kinase

chr8_-_61902669 3.759 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr1_+_74791516 3.303 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr12_+_79029150 2.759 ENSMUST00000039928.5
 Plekhh1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr6_+_4755327 2.624 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr18_+_4994600 2.298 ENSMUST00000140448.1
 Svil
supervillin
chr5_+_92925400 2.062 ENSMUST00000172706.1
 Shroom3
shroom family member 3
chr17_-_35000848 2.002 ENSMUST00000166828.3
 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr10_-_120899067 1.937 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr19_+_46304709 1.923 ENSMUST00000073116.5
 Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr2_-_151973387 1.921 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A
chr17_-_35000746 1.907 ENSMUST00000163360.1
 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr4_+_100776664 1.904 ENSMUST00000030257.8
ENSMUST00000097955.2
 Cachd1

cache domain containing 1

chr7_-_103843154 1.900 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr19_-_58454580 1.852 ENSMUST00000129100.1
ENSMUST00000123957.1
 Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr6_+_48841476 1.844 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr12_-_91746020 1.842 ENSMUST00000166967.1
 Ston2
stonin 2
chr6_+_48841633 1.840 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 228 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.4 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.3 6.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 4.2 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.3 4.1 GO:0003334 keratinocyte development(GO:0003334)
1.3 3.8 GO:0097350 neutrophil clearance(GO:0097350)
0.3 3.3 GO:0048733 sebaceous gland development(GO:0048733)
0.3 3.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.3 3.0 GO:0008063 Toll signaling pathway(GO:0008063)
0.9 2.8 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.1 2.6 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 2.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.5 2.2 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.0 2.2 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.0 2.1 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.3 2.0 GO:0007296 vitellogenesis(GO:0007296)
0.0 2.0 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.5 1.9 GO:0030091 protein repair(GO:0030091)
0.4 1.9 GO:0015671 oxygen transport(GO:0015671)
0.1 1.9 GO:0002467 germinal center formation(GO:0002467)
0.6 1.8 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 4.6 GO:0002102 podosome(GO:0002102)
0.2 4.4 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.6 4.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 2.9 GO:0043296 apical junction complex(GO:0043296)
0.6 2.8 GO:0031523 Myb complex(GO:0031523)
0.2 2.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 2.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.4 GO:0005882 intermediate filament(GO:0005882)
0.0 2.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.3 GO:0030496 midbody(GO:0030496)
0.0 2.1 GO:0043034 costamere(GO:0043034)
0.2 1.9 GO:0005833 hemoglobin complex(GO:0005833)
0.4 1.8 GO:0043020 NADPH oxidase complex(GO:0043020)
0.4 1.8 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 1.8 GO:0035861 site of double-strand break(GO:0035861)
0.0 1.7 GO:0008180 COP9 signalosome(GO:0008180)
0.4 1.6 GO:0008537 proteasome activator complex(GO:0008537)
0.0 1.6 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 1.4 GO:0042612 MHC class I protein complex(GO:0042612)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 GO:0005178 integrin binding(GO:0005178)
2.0 5.9 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 4.1 GO:0051015 actin filament binding(GO:0051015)
0.1 4.0 GO:0005109 frizzled binding(GO:0005109)
0.3 3.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 3.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.3 3.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 3.0 GO:0031996 thioesterase binding(GO:0031996)
0.7 2.8 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 2.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.5 1.9 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.3 1.9 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 1.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.5 1.8 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 1.7 GO:0046977 TAP binding(GO:0046977)
0.0 1.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 1.6 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.1 1.6 GO:0019215 intermediate filament binding(GO:0019215)
0.1 1.6 GO:0070410 co-SMAD binding(GO:0070410)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 6.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 5.1 PID_FGF_PATHWAY FGF signaling pathway
0.1 4.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 3.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 3.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.7 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 3.1 PID_IL23_PATHWAY IL23-mediated signaling events
0.1 3.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 2.6 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 2.5 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 2.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.6 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.1 1.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.3 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.9 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 5.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 3.1 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 3.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.8 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 1.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.7 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 1.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.6 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 1.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 1.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.2 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 1.2 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.2 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 1.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 1.1 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.1 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.1 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling