Motif ID: Pparg_Rxrg

Z-value: 1.071

Transcription factors associated with Pparg_Rxrg:

Gene SymbolEntrez IDGene Name
Pparg ENSMUSG00000000440.6 Pparg
Rxrg ENSMUSG00000015843.4 Rxrg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rxrgmm10_v2_chr1_+_167598384_167598411-0.608.7e-03Click!


Activity profile for motif Pparg_Rxrg.

activity profile for motif Pparg_Rxrg


Sorted Z-values histogram for motif Pparg_Rxrg

Sorted Z-values for motif Pparg_Rxrg



Network of associatons between targets according to the STRING database.



First level regulatory network of Pparg_Rxrg

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 2.620 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr17_+_35049966 1.916 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr2_+_126556128 1.675 ENSMUST00000141482.2
 Slc27a2
solute carrier family 27 (fatty acid transporter), member 2
chr17_-_56290499 1.611 ENSMUST00000019726.6
 Plin3
perilipin 3
chr5_+_110286306 1.533 ENSMUST00000007296.5
ENSMUST00000112482.1
 Pole

polymerase (DNA directed), epsilon

chr12_+_109452833 1.505 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr9_+_64117147 1.501 ENSMUST00000034969.7
 Lctl
lactase-like
chr13_-_24761861 1.489 ENSMUST00000006898.3
ENSMUST00000110382.2
 Gmnn

geminin

chr10_+_128790903 1.462 ENSMUST00000026411.6
 Mmp19
matrix metallopeptidase 19
chr2_+_165595009 1.453 ENSMUST00000088132.6
 Eya2
eyes absent 2 homolog (Drosophila)
chr11_-_100354040 1.410 ENSMUST00000173630.1
 Hap1
huntingtin-associated protein 1
chr4_-_126736236 1.402 ENSMUST00000048194.7
 Tfap2e
transcription factor AP-2, epsilon
chr6_-_124813065 1.249 ENSMUST00000149610.2
 Tpi1
triosephosphate isomerase 1
chr11_-_77894096 1.204 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr19_-_43912392 1.160 ENSMUST00000026209.4
 Dnmbp
dynamin binding protein
chr5_-_115119277 1.133 ENSMUST00000031524.7
 Acads
acyl-Coenzyme A dehydrogenase, short chain
chr18_-_41951187 1.129 ENSMUST00000070949.4
 Prelid2
PRELI domain containing 2
chrX_+_73639414 1.107 ENSMUST00000019701.8
 Dusp9
dual specificity phosphatase 9
chr7_+_4925802 1.096 ENSMUST00000057612.7
 Ssc5d
scavenger receptor cysteine rich domain containing (5 domains)
chrX_-_106485214 1.043 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 320 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.8 GO:0016576 histone dephosphorylation(GO:0016576)
0.3 2.6 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.1 2.2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.2 1.8 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.6 1.7 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.2 1.7 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.2 1.7 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 1.7 GO:0051099 positive regulation of binding(GO:0051099)
0.0 1.6 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 1.6 GO:0015914 phospholipid transport(GO:0015914)
0.5 1.5 GO:0045004 DNA replication proofreading(GO:0045004)
0.3 1.5 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.3 1.5 GO:0032493 response to bacterial lipoprotein(GO:0032493)
0.1 1.5 GO:0030574 collagen catabolic process(GO:0030574)
0.0 1.5 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 1.5 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 1.5 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.3 1.4 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.0 1.3 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.4 1.2 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.3 GO:0005903 brush border(GO:0005903)
0.2 2.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 2.0 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 2.0 GO:0001650 fibrillar center(GO:0001650)
0.0 2.0 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.2 1.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.7 GO:0005811 lipid particle(GO:0005811)
0.0 1.7 GO:0030496 midbody(GO:0030496)
0.0 1.7 GO:0031968 organelle outer membrane(GO:0031968)
0.3 1.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 1.5 GO:0016234 inclusion body(GO:0016234)
0.0 1.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 1.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.3 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.3 GO:0016459 myosin complex(GO:0016459)
0.2 1.1 GO:0001740 Barr body(GO:0001740)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 201 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.4 2.8 GO:0016918 retinal binding(GO:0016918)
0.2 2.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 2.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 2.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 1.9 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.2 1.7 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 1.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.5 1.6 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.4 1.6 GO:0008422 beta-glucosidase activity(GO:0008422)
0.3 1.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 1.6 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 1.5 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 1.4 GO:0008430 selenium binding(GO:0008430)
0.0 1.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 1.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.3 1.2 GO:0070991 medium-chain-acyl-CoA dehydrogenase activity(GO:0070991)
0.3 1.2 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 4.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.5 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.2 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.1 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 1.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.0 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.9 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.8 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.8 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.8 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.8 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.0 0.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.2 3.7 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.8 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.2 1.7 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.5 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 1.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.3 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.2 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0 1.2 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.1 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 1.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.1 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 1.0 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.0 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 0.9 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 0.9 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 0.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+