Motif ID: Etv4

Z-value: 0.630


Transcription factors associated with Etv4:

Gene SymbolEntrez IDGene Name
Etv4 ENSMUSG00000017724.8 Etv4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv4mm10_v2_chr11_-_101785252_101785371-0.038.9e-01Click!


Activity profile for motif Etv4.

activity profile for motif Etv4


Sorted Z-values histogram for motif Etv4

Sorted Z-values for motif Etv4



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_56133817 1.286 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr6_+_5725639 1.085 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr15_-_66969616 1.011 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr15_-_66812593 0.951 ENSMUST00000100572.3
 Sla
src-like adaptor
chr13_+_109632760 0.951 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr11_-_76509419 0.902 ENSMUST00000094012.4
 Abr
active BCR-related gene
chr7_+_45627482 0.811 ENSMUST00000057927.7
 Rasip1
Ras interacting protein 1
chr17_+_3397189 0.783 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr6_+_8259288 0.722 ENSMUST00000159335.1
 Gm16039
predicted gene 16039
chr9_-_29411736 0.704 ENSMUST00000115236.1
 Ntm
neurotrimin
chr11_-_45944910 0.679 ENSMUST00000129820.1
 Lsm11
U7 snRNP-specific Sm-like protein LSM11
chr9_+_107935876 0.632 ENSMUST00000035700.8
 Camkv
CaM kinase-like vesicle-associated
chr13_+_83504032 0.594 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr13_-_49309217 0.564 ENSMUST00000110087.2
 Fgd3
FYVE, RhoGEF and PH domain containing 3
chr5_+_117133567 0.541 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
 Taok3


TAO kinase 3


chr6_+_8259327 0.539 ENSMUST00000159378.1
 Gm16039
predicted gene 16039
chr5_-_103100054 0.518 ENSMUST00000112848.1
 Mapk10
mitogen-activated protein kinase 10
chr3_+_123267445 0.517 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr13_+_109260481 0.512 ENSMUST00000153234.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr12_-_84970814 0.511 ENSMUST00000165886.1
ENSMUST00000167448.1
ENSMUST00000043169.7
 Arel1


apoptosis resistant E3 ubiquitin protein ligase 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 156 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.1 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 1.1 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 1.0 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 1.0 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.2 0.9 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.1 0.9 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.8 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 0.8 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.8 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.2 0.7 GO:0014042 positive regulation of neuron maturation(GO:0014042)
0.2 0.6 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.1 0.6 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 0.6 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.0 0.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.6 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.1 0.5 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.1 0.5 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.1 0.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.5 GO:0007258 JUN phosphorylation(GO:0007258)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 1.1 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.1 0.9 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.8 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.7 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.7 GO:0031209 SCAR complex(GO:0031209)
0.0 0.7 GO:0031430 M band(GO:0031430)
0.0 0.7 GO:0030139 endocytic vesicle(GO:0030139)
0.1 0.6 GO:0097443 sorting endosome(GO:0097443)
0.1 0.6 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 0.6 GO:0071439 clathrin complex(GO:0071439)
0.0 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.6 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 0.5 GO:0005683 U7 snRNP(GO:0005683)
0.1 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 1.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 1.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.0 GO:0030276 clathrin binding(GO:0030276)
0.0 0.9 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 0.8 GO:0015643 toxic substance binding(GO:0015643)
0.2 0.7 GO:0071209 U7 snRNA binding(GO:0071209)
0.1 0.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.7 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 0.6 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441)
0.1 0.6 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 0.6 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.6 GO:0035198 miRNA binding(GO:0035198)
0.0 0.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.2 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.2 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.9 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.8 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.6 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.0 0.3 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.2 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.1 PID_FAS_PATHWAY FAS (CD95) signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.5 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.1 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.7 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.7 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.7 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.7 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.6 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.5 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.5 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.4 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 0.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.3 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport