Motif ID: Nkx6-3_Dbx2_Barx2

Z-value: 0.462

Transcription factors associated with Nkx6-3_Dbx2_Barx2:

Gene SymbolEntrez IDGene Name
Barx2 ENSMUSG00000032033.10 Barx2
Dbx2 ENSMUSG00000045608.6 Dbx2
Nkx6-3 ENSMUSG00000063672.6 Nkx6-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dbx2mm10_v2_chr15_-_95655960_956559600.653.3e-03Click!


Activity profile for motif Nkx6-3_Dbx2_Barx2.

activity profile for motif Nkx6-3_Dbx2_Barx2


Sorted Z-values histogram for motif Nkx6-3_Dbx2_Barx2

Sorted Z-values for motif Nkx6-3_Dbx2_Barx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-3_Dbx2_Barx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 135 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_102589687 1.923 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr14_+_80000292 1.793 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr16_+_11406618 1.645 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chrX_-_143933089 1.464 ENSMUST00000087313.3
 Dcx
doublecortin
chr4_-_14621805 1.439 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr13_+_94083490 1.396 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr17_-_81649607 1.347 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr10_-_110000219 1.326 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chr5_-_118244861 1.063 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chr5_-_62766153 0.896 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr13_+_83732438 0.881 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr9_-_15301555 0.845 ENSMUST00000034414.8
 4931406C07Rik
RIKEN cDNA 4931406C07 gene
chrX_-_143933204 0.818 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr8_+_34054622 0.731 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr5_-_70842617 0.729 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr13_-_105054895 0.702 ENSMUST00000063551.5
 Rgs7bp
regulator of G-protein signalling 7 binding protein
chr17_+_26715644 0.652 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr9_+_67840386 0.646 ENSMUST00000077879.5
 Vps13c
vacuolar protein sorting 13C (yeast)
chr5_+_144100387 0.608 ENSMUST00000041804.7
 Lmtk2
lemur tyrosine kinase 2
chr10_+_23797052 0.588 ENSMUST00000133289.1
 Slc18b1
solute carrier family 18, subfamily B, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 2.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.3 1.9 GO:0019532 oxalate transport(GO:0019532)
0.0 1.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.3 1.3 GO:0098735 cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735)
0.0 0.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 0.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.2 0.7 GO:0015866 ADP transport(GO:0015866)
0.1 0.7 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 0.6 GO:1901525 negative regulation of macromitophagy(GO:1901525) regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.0 0.6 GO:0033572 transferrin transport(GO:0033572)
0.0 0.6 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.1 0.5 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.5 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.5 GO:0032570 response to progesterone(GO:0032570)
0.1 0.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.3 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.3 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.3 GO:0090669 telomerase RNA stabilization(GO:0090669)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 GO:0030426 growth cone(GO:0030426)
0.1 1.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.8 GO:0042581 specific granule(GO:0042581)
0.0 1.7 GO:0030315 T-tubule(GO:0030315)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.5 GO:0016235 aggresome(GO:0016235)
0.1 0.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.1 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 1.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.3 1.3 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1 0.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 0.7 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.0 0.6 GO:0022857 transmembrane transporter activity(GO:0022857)
0.0 0.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.5 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.3 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.3 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.3 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.2 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 PID_ARF6_PATHWAY Arf6 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 2.0 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 1.3 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.5 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.3 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.1 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins