Motif ID: Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 1.169

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2:

Gene SymbolEntrez IDGene Name
Bhlhe41 ENSMUSG00000030256.5 Bhlhe41
Srebf1 ENSMUSG00000020538.9 Srebf1
Srebf2 ENSMUSG00000022463.7 Srebf2
Tfeb ENSMUSG00000023990.12 Tfeb
Usf1 ENSMUSG00000026641.7 Usf1
Usf2 ENSMUSG00000058239.7 Usf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srebf2mm10_v2_chr15_+_82147238_821472750.581.1e-02Click!
Tfebmm10_v2_chr17_+_47737030_477371070.522.5e-02Click!
Usf1mm10_v2_chr1_+_171411305_1714113370.371.3e-01Click!
Usf2mm10_v2_chr7_-_30956742_309568030.371.3e-01Click!
Srebf1mm10_v2_chr11_-_60210410_602104650.341.7e-01Click!


Activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2.

activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2


Sorted Z-values histogram for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Sorted Z-values for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_148038769 8.287 ENSMUST00000030879.5
ENSMUST00000137724.1
 Clcn6

chloride channel 6

chr17_-_66077022 7.737 ENSMUST00000150766.1
ENSMUST00000038116.5
 Ankrd12

ankyrin repeat domain 12

chr3_-_89773221 7.418 ENSMUST00000038450.1
 4632404H12Rik
RIKEN cDNA 4632404H12 gene
chr2_+_4300462 6.818 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr5_-_136170634 6.184 ENSMUST00000041048.1
 Orai2
ORAI calcium release-activated calcium modulator 2
chr2_-_164833438 5.590 ENSMUST00000042775.4
 Neurl2
neuralized-like 2 (Drosophila)
chr15_+_66577536 5.303 ENSMUST00000048188.8
 Phf20l1
PHD finger protein 20-like 1
chr4_+_148039097 4.879 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr16_-_45158624 4.873 ENSMUST00000180636.1
 Slc35a5
solute carrier family 35, member A5
chr16_-_45158183 4.869 ENSMUST00000114600.1
 Slc35a5
solute carrier family 35, member A5
chr4_+_148039035 4.854 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr16_-_23988852 4.776 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr15_-_77956658 4.699 ENSMUST00000117725.1
ENSMUST00000016696.6
 Foxred2

FAD-dependent oxidoreductase domain containing 2

chr4_-_45084538 4.459 ENSMUST00000052236.6
 Fbxo10
F-box protein 10
chr10_+_86021961 4.224 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chr5_-_123572976 4.217 ENSMUST00000031388.8
 Vps33a
vacuolar protein sorting 33A (yeast)
chr16_-_93794882 4.078 ENSMUST00000180967.1
 2310043M15Rik
RIKEN cDNA 2310043M15 gene
chr7_-_46795661 4.046 ENSMUST00000123725.1
 Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr5_-_148995147 3.997 ENSMUST00000147473.1
 Katnal1
katanin p60 subunit A-like 1
chr16_-_44139003 3.911 ENSMUST00000124102.1
 Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 337 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.4 GO:0008643 carbohydrate transport(GO:0008643)
0.5 13.8 GO:0097352 autophagosome maturation(GO:0097352)
0.3 12.5 GO:1902476 chloride transmembrane transport(GO:1902476)
0.2 11.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 11.1 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
2.4 9.7 GO:0070829 heterochromatin maintenance(GO:0070829)
0.2 9.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
2.6 7.8 GO:0043379 memory T cell differentiation(GO:0043379)
0.3 6.4 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.2 6.4 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 6.3 GO:0007596 blood coagulation(GO:0007596)
0.1 5.9 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.3 5.6 GO:0002115 store-operated calcium entry(GO:0002115)
0.1 5.2 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 5.0 GO:0045214 sarcomere organization(GO:0045214)
1.2 4.8 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.1 4.7 GO:0008333 endosome to lysosome transport(GO:0008333)
1.5 4.5 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
1.5 4.5 GO:1904959 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003) regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.8 4.5 GO:0051013 microtubule severing(GO:0051013)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 160 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.0 GO:0000139 Golgi membrane(GO:0000139)
0.1 12.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 12.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.4 9.7 GO:0033263 CORVET complex(GO:0033263)
0.0 7.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 7.7 GO:0030427 site of polarized growth(GO:0030427)
0.0 7.5 GO:0045202 synapse(GO:0045202)
0.8 7.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
1.8 7.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.5 6.7 GO:1990635 proximal dendrite(GO:1990635)
1.9 5.6 GO:0005927 muscle tendon junction(GO:0005927)
1.3 5.3 GO:0019034 viral replication complex(GO:0019034)
0.5 4.7 GO:0071141 SMAD protein complex(GO:0071141)
0.1 4.5 GO:0035861 site of double-strand break(GO:0035861)
0.3 4.2 GO:0043196 varicosity(GO:0043196)
0.0 4.2 GO:0055037 recycling endosome(GO:0055037)
0.4 3.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.4 3.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 3.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 3.7 GO:0005905 clathrin-coated pit(GO:0005905)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 235 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 22.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.8 19.2 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.7 11.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.5 9.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
3.2 9.7 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 7.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.3 6.9 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 6.2 GO:0070064 proline-rich region binding(GO:0070064)
0.1 6.2 GO:0015485 cholesterol binding(GO:0015485)
0.2 6.0 GO:0051018 protein kinase A binding(GO:0051018)
0.3 5.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 5.4 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.4 5.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.8 5.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 5.1 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.7 4.9 GO:0033592 RNA strand annealing activity(GO:0033592)
0.8 4.8 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.2 4.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
1.5 4.5 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.4 4.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 6.4 PID_LKB1_PATHWAY LKB1 signaling events
0.1 6.2 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 3.2 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 2.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.2 2.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.3 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.1 2.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 2.0 PID_P73PATHWAY p73 transcription factor network
0.1 1.9 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.4 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 1.3 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 1.2 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 1.2 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.1 1.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.0 PID_ATM_PATHWAY ATM pathway
0.0 1.0 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 7.4 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 5.8 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 5.2 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ Genes involved in Formation of RNA Pol II elongation complex
0.2 5.1 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 4.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 4.3 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.3 4.1 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 4.0 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.8 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.3 3.7 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 3.6 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 3.3 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 2.9 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.8 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 2.7 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.3 2.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.2 2.3 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.2 2.2 REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.1 1.8 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex