Motif ID: Foxb1

Z-value: 0.698


Transcription factors associated with Foxb1:

Gene SymbolEntrez IDGene Name
Foxb1 ENSMUSG00000059246.4 Foxb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxb1mm10_v2_chr9_-_69760924_69760940-0.087.6e-01Click!


Activity profile for motif Foxb1.

activity profile for motif Foxb1


Sorted Z-values histogram for motif Foxb1

Sorted Z-values for motif Foxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 85 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_53850243 1.747 ENSMUST00000048485.5
 Sln
sarcolipin
chr1_-_72536930 1.563 ENSMUST00000047786.5
 March4
membrane-associated ring finger (C3HC4) 4
chr2_-_65529275 1.023 ENSMUST00000126837.1
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr19_-_28911879 0.975 ENSMUST00000179171.1
 AC163993.1
AC163993.1
chr18_+_36952621 0.973 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr2_+_55437100 0.970 ENSMUST00000112633.2
ENSMUST00000112632.1
 Kcnj3

potassium inwardly-rectifying channel, subfamily J, member 3

chr4_+_102430047 0.885 ENSMUST00000172616.1
 Pde4b
phosphodiesterase 4B, cAMP specific
chr8_+_66386292 0.852 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr10_+_60106452 0.850 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr17_+_70522083 0.844 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chrX_+_41401128 0.828 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr10_+_69925766 0.795 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
 Ank3


ankyrin 3, epithelial


chr10_+_69925484 0.793 ENSMUST00000182692.1
ENSMUST00000092433.5
 Ank3

ankyrin 3, epithelial

chr3_-_123672321 0.772 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr10_+_69925954 0.771 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
 Ank3


ankyrin 3, epithelial


chr2_-_45110336 0.751 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr16_-_74411292 0.680 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr10_+_38965515 0.657 ENSMUST00000019992.5
 Lama4
laminin, alpha 4
chr15_-_11905609 0.619 ENSMUST00000066529.3
 Npr3
natriuretic peptide receptor 3
chr6_+_8948608 0.619 ENSMUST00000160300.1
 Nxph1
neurexophilin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 1.7 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.2 1.4 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 1.4 GO:0070842 aggresome assembly(GO:0070842)
0.2 1.0 GO:0046684 response to pyrethroid(GO:0046684)
0.1 1.0 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 0.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.9 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 0.8 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.8 GO:0001919 regulation of receptor recycling(GO:0001919)
0.2 0.7 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.7 GO:0060746 parental behavior(GO:0060746)
0.0 0.7 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.2 0.6 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.1 0.6 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 0.6 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.0 0.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 0.5 GO:0007525 somatic muscle development(GO:0007525)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.6 GO:0005795 Golgi stack(GO:0005795)
0.0 1.3 GO:0030315 T-tubule(GO:0030315)
0.1 1.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.8 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.7 GO:0005605 basal lamina(GO:0005605)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.1 0.6 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0030507 spectrin binding(GO:0030507)
0.3 1.4 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.0 1.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 1.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.0 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.9 GO:0042287 MHC protein binding(GO:0042287)
0.1 0.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 0.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.6 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.4 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.1 0.3 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.0 0.3 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.3 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.0 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.8 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.6 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.3 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism