Motif ID: Foxb1

Z-value: 0.698


Transcription factors associated with Foxb1:

Gene SymbolEntrez IDGene Name
Foxb1 ENSMUSG00000059246.4 Foxb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxb1mm10_v2_chr9_-_69760924_69760940-0.087.6e-01Click!


Activity profile for motif Foxb1.

activity profile for motif Foxb1


Sorted Z-values histogram for motif Foxb1

Sorted Z-values for motif Foxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_53850243 1.747 ENSMUST00000048485.5
 Sln
sarcolipin
chr1_-_72536930 1.563 ENSMUST00000047786.5
 March4
membrane-associated ring finger (C3HC4) 4
chr2_-_65529275 1.023 ENSMUST00000126837.1
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr19_-_28911879 0.975 ENSMUST00000179171.1
 AC163993.1
AC163993.1
chr18_+_36952621 0.973 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr2_+_55437100 0.970 ENSMUST00000112633.2
ENSMUST00000112632.1
 Kcnj3

potassium inwardly-rectifying channel, subfamily J, member 3

chr4_+_102430047 0.885 ENSMUST00000172616.1
 Pde4b
phosphodiesterase 4B, cAMP specific
chr8_+_66386292 0.852 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr10_+_60106452 0.850 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr17_+_70522083 0.844 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chrX_+_41401128 0.828 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr10_+_69925766 0.795 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
 Ank3


ankyrin 3, epithelial


chr10_+_69925484 0.793 ENSMUST00000182692.1
ENSMUST00000092433.5
 Ank3

ankyrin 3, epithelial

chr3_-_123672321 0.772 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr10_+_69925954 0.771 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
 Ank3


ankyrin 3, epithelial


chr2_-_45110336 0.751 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr16_-_74411292 0.680 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr10_+_38965515 0.657 ENSMUST00000019992.5
 Lama4
laminin, alpha 4
chr15_-_11905609 0.619 ENSMUST00000066529.3
 Npr3
natriuretic peptide receptor 3
chr6_+_8948608 0.619 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr10_+_69925800 0.618 ENSMUST00000182029.1
 Ank3
ankyrin 3, epithelial
chr3_+_136670076 0.606 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr3_-_123690806 0.598 ENSMUST00000154668.1
 Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr7_+_119900099 0.575 ENSMUST00000106516.1
 Lyrm1
LYR motif containing 1
chr17_+_70522149 0.563 ENSMUST00000140728.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr1_-_158814469 0.553 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr13_+_5861489 0.502 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr14_-_93888732 0.476 ENSMUST00000068992.2
 Pcdh9
protocadherin 9
chr9_-_101198999 0.475 ENSMUST00000066773.7
 Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chrX_-_94123087 0.471 ENSMUST00000113925.1
 Zfx
zinc finger protein X-linked
chrX_+_109095359 0.462 ENSMUST00000033598.8
 Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr6_+_14901344 0.460 ENSMUST00000115477.1
 Foxp2
forkhead box P2
chr6_+_14901440 0.426 ENSMUST00000128567.1
 Foxp2
forkhead box P2
chr15_-_48791933 0.415 ENSMUST00000160658.1
ENSMUST00000100670.3
ENSMUST00000162830.1
 Csmd3


CUB and Sushi multiple domains 3


chr18_-_43687695 0.402 ENSMUST00000082254.6
 Jakmip2
janus kinase and microtubule interacting protein 2
chr3_+_96245530 0.394 ENSMUST00000074976.6
 Hist2h2aa1
histone cluster 2, H2aa1
chr5_+_66676098 0.381 ENSMUST00000031131.9
 Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr7_+_27591513 0.373 ENSMUST00000108344.2
 Akt2
thymoma viral proto-oncogene 2
chr3_-_127499095 0.368 ENSMUST00000182594.1
 Ank2
ankyrin 2, brain
chr11_-_98329641 0.365 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chr1_+_179961110 0.360 ENSMUST00000076687.5
ENSMUST00000097450.3
 Cdc42bpa

CDC42 binding protein kinase alpha

chr3_-_96240317 0.355 ENSMUST00000078756.5
 Hist2h2aa2
histone cluster 2, H2aa2
chr7_+_29071597 0.339 ENSMUST00000180926.1
 Gm26604
predicted gene, 26604
chr12_-_84450944 0.329 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr5_-_137502402 0.314 ENSMUST00000111035.1
ENSMUST00000031728.4
 Pop7

processing of precursor 7, ribonuclease P family, (S. cerevisiae)

chr1_+_179960472 0.306 ENSMUST00000097453.2
ENSMUST00000111117.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr7_+_120842824 0.304 ENSMUST00000047875.8
 Eef2k
eukaryotic elongation factor-2 kinase
chr1_+_81077204 0.303 ENSMUST00000123720.1
 Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr5_-_34187670 0.300 ENSMUST00000042701.6
ENSMUST00000119171.1
 Mxd4

Max dimerization protein 4

chr1_+_25830657 0.294 ENSMUST00000064487.1
 Gm9884
predicted gene 9884
chr1_+_179546303 0.293 ENSMUST00000040706.8
 Cnst
consortin, connexin sorting protein
chr3_-_146781351 0.271 ENSMUST00000005164.7
 Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr8_+_93810832 0.265 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr13_-_12464925 0.261 ENSMUST00000124888.1
 Lgals8
lectin, galactose binding, soluble 8
chr7_+_27591705 0.244 ENSMUST00000167435.1
 Akt2
thymoma viral proto-oncogene 2
chr8_+_58912257 0.239 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr2_-_176917518 0.237 ENSMUST00000108931.2
 Gm14296
predicted gene 14296
chrX_+_119927196 0.225 ENSMUST00000040961.2
ENSMUST00000113366.1
 Pabpc5

poly(A) binding protein, cytoplasmic 5

chr6_-_56362356 0.215 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C



chr13_-_97747373 0.198 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr19_+_47228804 0.190 ENSMUST00000111807.3
 Neurl1a
neuralized homolog 1A (Drosophila)
chr6_+_34709610 0.186 ENSMUST00000031775.6
 Cald1
caldesmon 1
chr16_-_34095983 0.184 ENSMUST00000114973.1
ENSMUST00000114964.1
 Kalrn

kalirin, RhoGEF kinase

chr1_+_10056922 0.179 ENSMUST00000149214.1
 Cspp1
centrosome and spindle pole associated protein 1
chr10_+_111506286 0.158 ENSMUST00000164773.1
 Phlda1
pleckstrin homology-like domain, family A, member 1
chr1_+_43445736 0.152 ENSMUST00000086421.5
ENSMUST00000114744.1
 Nck2

non-catalytic region of tyrosine kinase adaptor protein 2

chr1_-_179546261 0.139 ENSMUST00000027769.5
 Tfb2m
transcription factor B2, mitochondrial
chr13_+_40859768 0.114 ENSMUST00000110191.2
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr4_-_135494615 0.112 ENSMUST00000102549.3
 Nipal3
NIPA-like domain containing 3
chrX_-_43274786 0.101 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr5_-_88527841 0.098 ENSMUST00000087033.3
 Igj
immunoglobulin joining chain
chr3_+_76075583 0.075 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chrX_+_150594420 0.075 ENSMUST00000112713.2
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr4_-_135494499 0.068 ENSMUST00000105856.2
 Nipal3
NIPA-like domain containing 3
chr15_+_43477213 0.065 ENSMUST00000022962.6
 Emc2
ER membrane protein complex subunit 2
chr12_-_101958148 0.064 ENSMUST00000159883.1
ENSMUST00000160251.1
ENSMUST00000161011.1
ENSMUST00000021606.5
 Atxn3



ataxin 3



chr10_-_93311073 0.043 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr9_+_47530173 0.042 ENSMUST00000114548.1
ENSMUST00000152459.1
ENSMUST00000143026.1
ENSMUST00000085909.2
ENSMUST00000114547.1
ENSMUST00000034581.3
 Cadm1





cell adhesion molecule 1





chr1_-_120120138 0.032 ENSMUST00000112648.1
ENSMUST00000128408.1
 Dbi

diazepam binding inhibitor

chr6_+_92940572 0.027 ENSMUST00000181145.1
ENSMUST00000181840.1
 9530026P05Rik

RIKEN cDNA 9530026P05 gene

chr10_-_61979073 0.026 ENSMUST00000105453.1
ENSMUST00000105452.2
ENSMUST00000105454.2
 Col13a1


collagen, type XIII, alpha 1


chr15_+_85116829 0.026 ENSMUST00000105085.1
 Gm10923
predicted gene 10923
chr14_+_34170640 0.017 ENSMUST00000104925.3
 Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chrX_+_101376359 0.004 ENSMUST00000119080.1
 Gjb1
gap junction protein, beta 1
chr4_-_139832920 0.000 ENSMUST00000174681.1
 Pax7
paired box gene 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.3 3.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 1.4 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.2 0.7 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 1.0 GO:0046684 response to pyrethroid(GO:0046684)
0.2 0.6 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.2 0.5 GO:0007525 somatic muscle development(GO:0007525)
0.1 1.0 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 0.8 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.6 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 0.4 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.1 0.3 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 1.4 GO:0070842 aggresome assembly(GO:0070842)
0.1 0.6 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.1 0.3 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 0.4 GO:0007412 axon target recognition(GO:0007412)
0.1 0.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.9 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.3 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.4 GO:0098907 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907)
0.0 0.2 GO:1903898 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.0 0.7 GO:0060746 parental behavior(GO:0060746)
0.0 0.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.7 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.3 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.2 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.8 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.0 GO:0009826 unidimensional cell growth(GO:0009826) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.2 GO:0046069 cGMP catabolic process(GO:0046069)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 0.6 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 1.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.8 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.7 GO:0005605 basal lamina(GO:0005605)
0.0 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 1.3 GO:0030315 T-tubule(GO:0030315)
0.0 1.6 GO:0005795 Golgi stack(GO:0005795)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.2 1.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.3 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.1 0.6 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.4 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.1 0.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 3.3 GO:0030507 spectrin binding(GO:0030507)
0.1 1.0 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.3 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.9 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 1.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.0 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.3 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.8 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 1.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.8 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.3 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 1.0 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.3 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism