Motif ID: Nr2c2

Z-value: 1.329


Transcription factors associated with Nr2c2:

Gene SymbolEntrez IDGene Name
Nr2c2 ENSMUSG00000005893.8 Nr2c2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2c2mm10_v2_chr6_+_92091378_92091390-0.857.7e-06Click!


Activity profile for motif Nr2c2.

activity profile for motif Nr2c2


Sorted Z-values histogram for motif Nr2c2

Sorted Z-values for motif Nr2c2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2c2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_97778042 3.885 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_-_138847579 3.725 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr2_+_165655237 3.050 ENSMUST00000063433.7
 Eya2
eyes absent 2 homolog (Drosophila)
chr1_+_12718496 2.851 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr7_+_79500081 2.704 ENSMUST00000181511.2
ENSMUST00000182937.1
 AI854517

expressed sequence AI854517

chr19_+_38395980 2.703 ENSMUST00000054098.2
 Slc35g1
solute carrier family 35, member G1
chr1_-_133424377 2.556 ENSMUST00000153799.1
 Sox13
SRY-box containing gene 13
chr7_+_79500018 2.550 ENSMUST00000182495.1
ENSMUST00000183043.1
 AI854517

expressed sequence AI854517

chr13_-_24761861 2.425 ENSMUST00000006898.3
ENSMUST00000110382.2
 Gmnn

geminin

chr6_-_95718800 2.422 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr7_-_143460989 2.386 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr11_-_90002881 2.370 ENSMUST00000020864.8
 Pctp
phosphatidylcholine transfer protein
chr1_-_163289214 2.368 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr8_+_88521344 2.340 ENSMUST00000034086.5
 Nkd1
naked cuticle 1 homolog (Drosophila)
chr10_+_88147061 2.316 ENSMUST00000169309.1
 Nup37
nucleoporin 37
chr1_+_166254095 2.154 ENSMUST00000111416.1
 Ildr2
immunoglobulin-like domain containing receptor 2
chr17_+_35049966 2.115 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr10_+_88146992 2.092 ENSMUST00000052355.7
 Nup37
nucleoporin 37
chr8_-_105707933 2.035 ENSMUST00000013299.9
 Enkd1
enkurin domain containing 1
chr6_+_29694204 1.960 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 231 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.7 5.1 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.2 5.0 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
1.5 4.6 GO:0030421 defecation(GO:0030421)
0.7 3.7 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 3.3 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.2 3.1 GO:0046643 regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
0.4 3.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 3.0 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 3.0 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 3.0 GO:0051604 protein maturation(GO:0051604)
0.7 2.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 2.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 2.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.5 2.7 GO:1990034 calcium ion export from cell(GO:1990034)
0.3 2.7 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0 2.7 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 2.6 GO:0051028 mRNA transport(GO:0051028)
0.3 2.4 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.3 2.4 GO:0006104 succinyl-CoA metabolic process(GO:0006104)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0005667 transcription factor complex(GO:0005667)
0.1 7.0 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 6.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.4 4.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.4 3.5 GO:0061574 ASAP complex(GO:0061574)
0.0 3.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 3.0 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 3.0 GO:0000791 euchromatin(GO:0000791)
0.1 3.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 3.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 2.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 2.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 2.7 GO:0031965 nuclear membrane(GO:0031965)
0.4 2.6 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.2 2.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 2.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 2.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.2 GO:0030496 midbody(GO:0030496)
0.2 2.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 2.0 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 5.9 GO:0008201 heparin binding(GO:0008201)
0.1 4.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 3.1 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 3.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.6 2.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.5 2.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 2.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 2.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.8 2.5 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.8 2.4 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.2 2.4 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.2 2.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 2.4 GO:0071837 HMG box domain binding(GO:0071837)
0.0 2.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.5 2.1 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 2.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 2.0 GO:0005254 chloride channel activity(GO:0005254)
0.6 1.9 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.2 1.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.8 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 4.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 3.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.9 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 2.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 1.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.5 PID_P73PATHWAY p73 transcription factor network
0.0 1.4 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.9 PID_FANCONI_PATHWAY Fanconi anemia pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 4.4 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 3.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 3.5 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.2 3.4 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0 3.1 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 2.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 2.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 2.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 2.6 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.4 2.5 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 2.4 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 2.3 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 1.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.7 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.6 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.4 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS Genes involved in Host Interactions of HIV factors
0.3 1.3 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol