Motif ID: Gcm2

Z-value: 1.917


Transcription factors associated with Gcm2:

Gene SymbolEntrez IDGene Name
Gcm2 ENSMUSG00000021362.6 Gcm2



Activity profile for motif Gcm2.

activity profile for motif Gcm2


Sorted Z-values histogram for motif Gcm2

Sorted Z-values for motif Gcm2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gcm2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065737 12.928 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr11_-_6065538 7.446 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr15_-_66831625 5.422 ENSMUST00000164163.1
 Sla
src-like adaptor
chr7_+_121392266 4.001 ENSMUST00000084628.3
 Hs3st2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr2_+_82053222 3.935 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr9_+_54764748 3.230 ENSMUST00000034830.8
 Crabp1
cellular retinoic acid binding protein I
chr11_+_98348404 3.102 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr19_+_6400523 2.823 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr14_-_102982630 2.723 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr9_+_112234257 2.668 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr12_-_79007276 2.546 ENSMUST00000056660.6
ENSMUST00000174721.1
 Tmem229b

transmembrane protein 229B

chr4_+_13743424 2.490 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr7_+_57591147 2.340 ENSMUST00000039697.7
 Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chr11_-_116654245 2.275 ENSMUST00000021166.5
 Cygb
cytoglobin
chr4_-_138396438 2.269 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chrX_+_41401304 2.263 ENSMUST00000076349.5
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr3_+_96596628 2.257 ENSMUST00000058943.7
 Ankrd34a
ankyrin repeat domain 34A
chr5_+_110544326 2.096 ENSMUST00000040001.7
 Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr2_-_32353247 2.059 ENSMUST00000078352.5
ENSMUST00000113352.2
ENSMUST00000113365.1
 Dnm1


dynamin 1


chr5_-_37717122 2.037 ENSMUST00000094836.4
 Stk32b
serine/threonine kinase 32B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 359 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.8 20.4 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.1 4.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.5 3.6 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 3.3 GO:0001881 receptor recycling(GO:0001881)
1.1 3.2 GO:0016115 terpenoid catabolic process(GO:0016115)
0.5 3.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.0 3.1 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.2 3.0 GO:0001553 luteinization(GO:0001553)
0.1 2.5 GO:0071625 vocalization behavior(GO:0071625)
0.1 2.4 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.5 2.3 GO:0015671 oxygen transport(GO:0015671)
0.3 2.3 GO:0046549 retinal cone cell development(GO:0046549)
0.3 2.3 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.3 2.3 GO:0071420 cellular response to histamine(GO:0071420)
0.1 2.3 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 2.3 GO:0071277 cellular response to calcium ion(GO:0071277)
0.3 2.1 GO:0032782 bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 2.1 GO:0060074 synapse maturation(GO:0060074)
0.1 2.0 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.2 1.9 GO:0016486 peptide hormone processing(GO:0016486)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 20.4 GO:0051233 spindle midzone(GO:0051233)
0.4 7.0 GO:0043196 varicosity(GO:0043196)
0.1 6.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 6.5 GO:0044306 neuron projection terminus(GO:0044306)
0.1 4.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 4.1 GO:0031225 anchored component of membrane(GO:0031225)
0.3 3.9 GO:0043083 synaptic cleft(GO:0043083)
0.0 3.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 3.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 2.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 2.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 2.4 GO:0097433 dense body(GO:0097433)
0.2 2.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 2.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 2.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 2.2 GO:0032279 asymmetric synapse(GO:0032279)
0.1 2.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 2.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 242 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 21.2 GO:0043274 phospholipase binding(GO:0043274)
0.1 5.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 4.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 4.4 GO:0008289 lipid binding(GO:0008289)
0.2 4.1 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.6 4.0 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.3 3.8 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.4 3.6 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 3.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
1.0 3.1 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.5 3.1 GO:0019841 retinol binding(GO:0019841)
0.6 2.3 GO:0004096 catalase activity(GO:0004096)
0.5 2.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.4 2.3 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 2.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 2.3 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 2.2 GO:0030507 spectrin binding(GO:0030507)
0.1 2.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.1 GO:0017046 peptide hormone binding(GO:0017046)
0.7 2.0 GO:0004936 alpha-adrenergic receptor activity(GO:0004936) epinephrine binding(GO:0051379)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 18.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 3.9 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 3.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 3.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 2.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 2.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.7 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 1.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 1.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.3 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.2 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 1.1 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 1.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.0 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 1.0 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 0.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.8 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.8 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 25.3 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 5.8 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.3 5.6 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 5.4 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism
0.1 5.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 3.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 2.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 2.3 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.1 2.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 2.2 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.1 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 1.9 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.9 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 1.8 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.6 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.1 1.5 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.5 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits