Motif ID: Mybl1

Z-value: 1.542


Transcription factors associated with Mybl1:

Gene SymbolEntrez IDGene Name
Mybl1 ENSMUSG00000025912.10 Mybl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybl1mm10_v2_chr1_-_9700209_9700329-0.262.9e-01Click!


Activity profile for motif Mybl1.

activity profile for motif Mybl1


Sorted Z-values histogram for motif Mybl1

Sorted Z-values for motif Mybl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mybl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 9.604 ENSMUST00000075312.3
 Ttr
transthyretin
chr17_+_29093763 4.681 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr4_-_154097105 4.161 ENSMUST00000105643.1
ENSMUST00000133533.1
ENSMUST00000097762.4
 Trp73


transformation related protein 73


chr19_+_60144682 4.143 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr14_-_48662740 3.175 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr9_+_78191966 3.152 ENSMUST00000034903.5
 Gsta4
glutathione S-transferase, alpha 4
chr11_-_69921190 2.792 ENSMUST00000108607.1
 Eif5a
eukaryotic translation initiation factor 5A
chr4_-_41695442 2.723 ENSMUST00000102961.3
ENSMUST00000064443.6
 Cntfr

ciliary neurotrophic factor receptor

chr8_+_83715504 2.691 ENSMUST00000109810.1
 Ddx39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
chrX_-_106485214 2.659 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1
chr11_-_106999369 2.612 ENSMUST00000106768.1
ENSMUST00000144834.1
 Kpna2

karyopherin (importin) alpha 2

chr6_+_124829540 2.433 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr11_+_59306920 2.411 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr2_+_118814237 2.401 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr10_-_96409038 2.346 ENSMUST00000179683.1
 Gm20091
predicted gene, 20091
chr6_+_124829582 2.341 ENSMUST00000024270.7
 Cdca3
cell division cycle associated 3
chr2_+_118814195 2.247 ENSMUST00000110842.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr11_-_106999482 2.240 ENSMUST00000018506.6
 Kpna2
karyopherin (importin) alpha 2
chr2_+_118813995 2.230 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr9_+_7764041 2.216 ENSMUST00000052865.9
 Tmem123
transmembrane protein 123

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 258 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 9.6 GO:0070327 thyroid hormone transport(GO:0070327)
1.3 7.8 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.3 7.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.4 6.9 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.5 6.5 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.2 5.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.1 4.4 GO:0003360 brainstem development(GO:0003360)
0.6 3.7 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.9 3.6 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.1 3.5 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 3.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.8 3.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 3.1 GO:0051384 response to glucocorticoid(GO:0051384)
0.4 2.9 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.2 2.8 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.6 2.5 GO:0042360 vitamin E metabolic process(GO:0042360)
0.0 2.5 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.1 2.4 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.5 2.3 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.1 2.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.6 GO:0005615 extracellular space(GO:0005615)
0.2 8.1 GO:0035371 microtubule plus-end(GO:0035371)
0.1 8.0 GO:0005643 nuclear pore(GO:0005643)
0.7 7.8 GO:0005642 annulate lamellae(GO:0005642)
0.0 5.7 GO:0005913 cell-cell adherens junction(GO:0005913)
1.6 4.7 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 4.7 GO:0005681 spliceosomal complex(GO:0005681)
1.5 4.4 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 3.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 3.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 3.2 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 3.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 3.1 GO:0005871 kinesin complex(GO:0005871)
0.1 2.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 2.5 GO:0035861 site of double-strand break(GO:0035861)
0.1 2.4 GO:0000242 pericentriolar material(GO:0000242)
0.1 2.3 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 2.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.8 GO:0031011 Ino80 complex(GO:0031011)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 9.6 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 8.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 7.9 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 6.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 5.2 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
1.6 4.7 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.7 4.4 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.2 4.0 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 3.2 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 2.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.5 2.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 2.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 2.5 GO:0005179 hormone activity(GO:0005179)
0.5 2.4 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 2.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 2.3 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.1 2.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 2.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.4 2.2 GO:0032027 myosin light chain binding(GO:0032027)
0.4 2.2 GO:0008494 translation activator activity(GO:0008494)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 6.2 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.5 4.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 4.7 PID_PLK1_PATHWAY PLK1 signaling events
0.0 2.9 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 2.6 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 2.4 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.1 2.4 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 2.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.5 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.2 PID_P73PATHWAY p73 transcription factor network
0.0 1.0 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 0.9 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 0.8 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.4 REACTOME_AMYLOIDS Genes involved in Amyloids
0.3 7.8 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 6.3 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 4.6 REACTOME_KINESINS Genes involved in Kinesins
0.2 4.5 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 4.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 4.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 3.5 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 3.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 3.4 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 3.3 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 3.0 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 2.8 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 2.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 2.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 2.5 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.4 2.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 2.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.2 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 2.1 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication