Motif ID: Hlx

Z-value: 0.305


Transcription factors associated with Hlx:

Gene SymbolEntrez IDGene Name
Hlx ENSMUSG00000039377.6 Hlx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hlxmm10_v2_chr1_-_184732616_184732627-0.087.7e-01Click!


Activity profile for motif Hlx.

activity profile for motif Hlx


Sorted Z-values histogram for motif Hlx

Sorted Z-values for motif Hlx



Network of associatons between targets according to the STRING database.



First level regulatory network of Hlx

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_143933089 0.844 ENSMUST00000087313.3
 Dcx
doublecortin
chr15_-_8710409 0.558 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_+_54980880 0.493 ENSMUST00000093844.3
 Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr17_-_50094277 0.375 ENSMUST00000113195.1
 Rftn1
raftlin lipid raft linker 1
chrX_-_143933204 0.355 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr15_-_8710734 0.329 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_+_7555053 0.260 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr1_+_180109192 0.219 ENSMUST00000143176.1
ENSMUST00000135056.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr5_+_121749196 0.150 ENSMUST00000161064.1
 Atxn2
ataxin 2
chr7_-_34313531 0.078 ENSMUST00000108074.1
 4931406P16Rik
RIKEN cDNA 4931406P16 gene
chr15_+_81744848 0.072 ENSMUST00000109554.1
 Zc3h7b
zinc finger CCCH type containing 7B
chr3_+_32436376 0.024 ENSMUST00000108242.1
 Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr7_-_45103747 0.020 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr19_-_53944621 0.001 ENSMUST00000135402.2
 Bbip1
BBSome interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 0.3 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.1 1.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.5 GO:0035095 behavioral response to nicotine(GO:0035095)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.3 GO:0071855 neuropeptide receptor binding(GO:0071855)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.9 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters