Motif ID: Ets1

Z-value: 0.691


Transcription factors associated with Ets1:

Gene SymbolEntrez IDGene Name
Ets1 ENSMUSG00000032035.9 Ets1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ets1mm10_v2_chr9_+_32696005_32696121-0.263.0e-01Click!


Activity profile for motif Ets1.

activity profile for motif Ets1


Sorted Z-values histogram for motif Ets1

Sorted Z-values for motif Ets1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ets1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_127218303 1.136 ENSMUST00000106313.1
 Sept1
septin 1
chr2_+_32646586 1.012 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chrY_+_1010543 0.886 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr7_-_127218390 0.846 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr19_+_8920358 0.823 ENSMUST00000096243.5
 B3gat3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr7_+_105640522 0.803 ENSMUST00000106785.1
ENSMUST00000106786.1
ENSMUST00000106780.1
ENSMUST00000106784.1
 Timm10b



translocase of inner mitochondrial membrane 10B



chr6_-_115994953 0.790 ENSMUST00000015511.8
 Plxnd1
plexin D1
chr7_+_126695942 0.721 ENSMUST00000106369.1
 Bola2
bolA-like 2 (E. coli)
chr2_+_121456963 0.674 ENSMUST00000126764.1
 Hypk
huntingtin interacting protein K
chr7_+_105640448 0.646 ENSMUST00000058333.3
 Timm10b
translocase of inner mitochondrial membrane 10B
chr11_-_70237761 0.645 ENSMUST00000108576.3
 0610010K14Rik
RIKEN cDNA 0610010K14 gene
chr7_-_27181149 0.633 ENSMUST00000071986.6
ENSMUST00000121848.1
 Mia

melanoma inhibitory activity

chr8_-_70897407 0.584 ENSMUST00000054220.8
 Rpl18a
ribosomal protein L18A
chr10_+_128748455 0.584 ENSMUST00000065210.8
 Wibg
within bgcn homolog (Drosophila)
chr13_+_55321991 0.570 ENSMUST00000021942.6
 Prelid1
PRELI domain containing 1
chr1_-_16656843 0.568 ENSMUST00000115352.3
 Tceb1
transcription elongation factor B (SIII), polypeptide 1
chr11_-_70237886 0.561 ENSMUST00000108577.1
ENSMUST00000108579.1
ENSMUST00000021181.6
ENSMUST00000108578.2
ENSMUST00000102569.3
 0610010K14Rik




RIKEN cDNA 0610010K14 gene




chr4_-_127313980 0.548 ENSMUST00000053753.7
 Gja4
gap junction protein, alpha 4
chr11_-_70237638 0.545 ENSMUST00000100950.3
 0610010K14Rik
RIKEN cDNA 0610010K14 gene
chr5_+_122391878 0.539 ENSMUST00000102525.4
 Arpc3
actin related protein 2/3 complex, subunit 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 344 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.0 GO:0051311 meiotic metaphase plate congression(GO:0051311)
0.1 1.8 GO:0043248 proteasome assembly(GO:0043248)
0.0 1.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 1.4 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 1.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.2 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.2 1.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 1.1 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645)
0.1 1.1 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 1.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 1.1 GO:0032543 mitochondrial translation(GO:0032543)
0.3 1.0 GO:1905072 detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072)
0.2 0.9 GO:2000256 endomitotic cell cycle(GO:0007113) positive regulation of male germ cell proliferation(GO:2000256)
0.1 0.9 GO:0032079 positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1 0.9 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 0.8 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.1 0.8 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.8 GO:0021539 subthalamus development(GO:0021539)
0.1 0.8 GO:0071569 protein ufmylation(GO:0071569)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 3.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 2.7 GO:0016589 NURF complex(GO:0016589)
0.4 1.9 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 1.9 GO:0072687 meiotic spindle(GO:0072687)
0.2 1.7 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.6 GO:0072562 blood microparticle(GO:0072562)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 1.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 1.1 GO:0000242 pericentriolar material(GO:0000242)
0.1 1.0 GO:0034709 methylosome(GO:0034709)
0.1 1.0 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 1.0 GO:0005642 annulate lamellae(GO:0005642)
0.1 1.0 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 0.9 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.1 0.9 GO:0032433 filopodium tip(GO:0032433)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 211 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.5 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 1.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 1.3 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 1.1 GO:0070513 death domain binding(GO:0070513)
0.0 1.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 1.0 GO:0042610 CD8 receptor binding(GO:0042610)
0.2 1.0 GO:0005534 galactose binding(GO:0005534)
0.1 1.0 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 1.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.2 0.9 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1 0.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 0.8 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 0.8 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.8 GO:0050733 RS domain binding(GO:0050733)
0.0 0.8 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 1.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.4 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.2 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.2 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 1.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.0 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.7 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 0.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.6 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.5 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.2 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 3.2 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 3.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.6 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 1.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.3 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.2 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 1.1 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.0 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.0 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 0.9 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.9 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.9 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.8 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 0.7 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.7 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 0.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.6 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.6 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ Genes involved in Cleavage of Growing Transcript in the Termination Region