Motif ID: Stat2

Z-value: 2.943


Transcription factors associated with Stat2:

Gene SymbolEntrez IDGene Name
Stat2 ENSMUSG00000040033.9 Stat2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat2mm10_v2_chr10_+_128270546_1282705770.865.8e-06Click!


Activity profile for motif Stat2.

activity profile for motif Stat2


Sorted Z-values histogram for motif Stat2

Sorted Z-values for motif Stat2



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66812593 18.907 ENSMUST00000100572.3
 Sla
src-like adaptor
chr16_+_23609895 17.959 ENSMUST00000038423.5
 Rtp4
receptor transporter protein 4
chr1_-_173942445 13.031 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr6_+_90550789 12.979 ENSMUST00000130418.1
ENSMUST00000032175.8
 Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr10_+_13966268 10.578 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr12_-_78980758 10.106 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr1_+_153751946 9.453 ENSMUST00000183241.1
 Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr11_+_70459940 8.784 ENSMUST00000147289.1
ENSMUST00000126105.1
 Zmynd15

zinc finger, MYND-type containing 15

chr6_-_13839916 8.354 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr5_+_107497762 7.864 ENSMUST00000152474.1
ENSMUST00000060553.7
 A830010M20Rik

RIKEN cDNA A830010M20 gene

chr12_+_103434211 7.651 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr1_+_153751859 7.492 ENSMUST00000182538.1
 Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr2_+_4559742 6.917 ENSMUST00000176828.1
 Frmd4a
FERM domain containing 4A
chr17_+_86167777 6.675 ENSMUST00000097275.2
 Prkce
protein kinase C, epsilon
chr3_-_107760221 6.662 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr5_+_107497718 6.629 ENSMUST00000112671.2
 A830010M20Rik
RIKEN cDNA A830010M20 gene
chr11_-_70459957 6.359 ENSMUST00000019064.2
 Cxcl16
chemokine (C-X-C motif) ligand 16
chr7_-_141010759 6.296 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr1_-_170110491 6.251 ENSMUST00000027985.2
 Ddr2
discoidin domain receptor family, member 2
chr1_+_153749496 6.173 ENSMUST00000182722.1
 Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 28.0 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.7 24.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.3 18.9 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
6.0 18.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.6 16.4 GO:0034340 response to type I interferon(GO:0034340)
4.3 13.0 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.7 12.4 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.2 11.2 GO:0001919 regulation of receptor recycling(GO:0001919)
0.4 10.3 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 7.6 GO:0007286 spermatid development(GO:0007286)
0.0 7.2 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.7 7.0 GO:0010818 T cell chemotaxis(GO:0010818)
1.1 6.8 GO:0032439 endosome localization(GO:0032439)
1.7 6.7 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.8 6.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.4 6.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
1.5 6.1 GO:0044565 dendritic cell proliferation(GO:0044565)
2.0 5.9 GO:0046077 dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
1.2 5.9 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.9 5.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 28.0 GO:0016363 nuclear matrix(GO:0016363)
0.0 24.5 GO:0005739 mitochondrion(GO:0005739)
0.2 22.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 20.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 12.5 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.7 11.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 10.6 GO:0009986 cell surface(GO:0009986)
0.0 9.7 GO:0005730 nucleolus(GO:0005730)
0.0 8.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 8.7 GO:0005615 extracellular space(GO:0005615)
0.2 7.7 GO:0005637 nuclear inner membrane(GO:0005637)
2.2 6.7 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.7 6.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.9 5.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 4.9 GO:0036064 ciliary basal body(GO:0036064)
0.5 4.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 4.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.9 4.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 4.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.6 3.9 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 33.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 28.0 GO:0019843 rRNA binding(GO:0019843)
0.0 23.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.5 18.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
4.3 13.0 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.1 12.0 GO:0001664 G-protein coupled receptor binding(GO:0001664)
1.6 11.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 8.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 8.4 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 8.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 7.7 GO:0005521 lamin binding(GO:0005521)
0.2 7.7 GO:0070412 R-SMAD binding(GO:0070412)
1.7 6.7 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.1 6.7 GO:0008083 growth factor activity(GO:0008083)
0.6 6.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.7 6.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3 6.1 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
2.0 5.9 GO:0004127 cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041)
0.3 5.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 5.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 7.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.7 6.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4 6.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 5.4 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 5.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 4.5 PID_LKB1_PATHWAY LKB1 signaling events
0.1 4.3 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 4.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 4.1 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 4.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 3.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 3.4 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 3.0 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.3 2.6 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 2.1 PID_MYC_PATHWAY C-MYC pathway
0.0 1.7 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 1.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 49.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.5 11.2 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 8.4 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.3 7.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 6.7 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.3 6.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.6 4.7 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.3 4.5 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 4.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 4.2 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 4.1 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.1 3.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 2.7 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 2.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.0 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.0 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 1.6 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.1 1.6 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)