Motif ID: Hic2

Z-value: 1.799


Transcription factors associated with Hic2:

Gene SymbolEntrez IDGene Name
Hic2 ENSMUSG00000050240.8 Hic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hic2mm10_v2_chr16_+_17233560_172336640.058.4e-01Click!


Activity profile for motif Hic2.

activity profile for motif Hic2


Sorted Z-values histogram for motif Hic2

Sorted Z-values for motif Hic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_117781017 6.073 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr4_-_64046925 5.714 ENSMUST00000107377.3
 Tnc
tenascin C
chr11_+_104231573 5.415 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr11_+_104231515 5.118 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr15_-_66831625 5.065 ENSMUST00000164163.1
 Sla
src-like adaptor
chr11_+_104231465 4.959 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr1_-_56969864 4.907 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr11_+_104231390 4.760 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr10_+_127725392 4.660 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr6_+_103510874 4.582 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr1_-_56969827 4.454 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56978534 4.199 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_154725920 4.098 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr1_-_134234492 3.894 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor
chr12_-_79007276 3.778 ENSMUST00000056660.6
ENSMUST00000174721.1
 Tmem229b

transmembrane protein 229B

chr15_+_99224976 3.378 ENSMUST00000041415.3
 Kcnh3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr2_+_76406529 3.171 ENSMUST00000111929.1
ENSMUST00000077972.4
ENSMUST00000111930.2
 Osbpl6


oxysterol binding protein-like 6


chr1_-_134235420 3.142 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr1_+_74854954 2.963 ENSMUST00000160379.2
 Cdk5r2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr15_-_43869993 2.949 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 360 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 20.3 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.8 12.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.5 7.5 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923)
2.3 7.0 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
1.4 5.7 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.2 5.7 GO:0048266 behavioral response to pain(GO:0048266)
1.2 4.7 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.2 4.7 GO:0001553 luteinization(GO:0001553)
0.2 4.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 4.6 GO:0035640 exploration behavior(GO:0035640)
0.3 4.4 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.6 4.1 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.3 4.1 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.9 3.8 GO:2000211 regulation of glutamate metabolic process(GO:2000211)
0.5 3.6 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.8 3.3 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.6 3.3 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 3.3 GO:0033198 response to ATP(GO:0033198)
0.1 3.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.7 3.0 GO:0021586 pons maturation(GO:0021586)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 20.3 GO:0045298 tubulin complex(GO:0045298)
0.1 15.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.7 10.6 GO:0005614 interstitial matrix(GO:0005614)
0.2 9.9 GO:0048786 presynaptic active zone(GO:0048786)
0.2 9.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.4 8.5 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.6 6.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2 5.5 GO:0030673 axolemma(GO:0030673)
0.3 5.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 4.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 4.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 4.2 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 4.0 GO:0044309 neuron spine(GO:0044309)
0.1 3.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.4 3.8 GO:0070852 cell body fiber(GO:0070852)
1.1 3.4 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.2 3.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 3.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
1.0 3.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 2.8 GO:0005682 U5 snRNP(GO:0005682)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 232 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 21.3 GO:0099609 microtubule lateral binding(GO:0099609)
1.0 7.0 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
2.0 6.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 5.9 GO:0022839 ion gated channel activity(GO:0022839)
0.1 5.9 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
1.0 5.7 GO:0045545 syndecan binding(GO:0045545)
0.4 5.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 4.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 4.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.0 4.1 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.1 4.1 GO:0030552 cAMP binding(GO:0030552)
0.5 3.6 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 3.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.6 3.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.2 3.3 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 3.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.3 3.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 3.1 GO:0017022 myosin binding(GO:0017022)
0.1 3.1 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 3.1 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 20.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 7.7 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 5.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 3.8 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 3.8 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.2 3.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.2 3.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 3.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.8 PID_ARF_3PATHWAY Arf1 pathway
0.1 2.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.4 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 2.2 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 2.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.0 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 1.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.6 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 1.4 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 1.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.4 PID_RAS_PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 20.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 8.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.6 7.7 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.2 6.2 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 4.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 4.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.9 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.2 3.8 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.3 3.3 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 3.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.9 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 2.8 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.3 2.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 2.5 REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS Genes involved in Post NMDA receptor activation events
0.1 2.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 2.2 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 2.0 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 2.0 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 2.0 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 1.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation