Motif ID: Rfx5

Z-value: 1.047


Transcription factors associated with Rfx5:

Gene SymbolEntrez IDGene Name
Rfx5 ENSMUSG00000005774.6 Rfx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_94954226-0.428.3e-02Click!


Activity profile for motif Rfx5.

activity profile for motif Rfx5


Sorted Z-values histogram for motif Rfx5

Sorted Z-values for motif Rfx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 68 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_30664986 2.712 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr2_+_122147680 2.588 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr17_+_35861318 2.329 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr7_-_105752193 2.292 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I
chr7_-_45092130 2.098 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr12_+_108334341 2.059 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr17_+_37270214 2.049 ENSMUST00000038580.6
 H2-M3
histocompatibility 2, M region locus 3
chr7_+_46841475 2.032 ENSMUST00000147535.1
 Ldha
lactate dehydrogenase A
chr17_+_35861343 1.793 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr18_-_51865881 1.693 ENSMUST00000091905.2
 Gm4950
predicted pseudogene 4950
chr17_+_34263209 1.661 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr1_-_183147461 1.651 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr7_-_45091713 1.608 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr8_-_89187560 1.507 ENSMUST00000093326.2
 Gm5356
predicted pseudogene 5356
chr19_-_4615647 1.464 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr17_-_24886304 1.448 ENSMUST00000044252.5
 Nubp2
nucleotide binding protein 2
chr7_+_100537192 1.403 ENSMUST00000120454.1
 Coa4
cytochrome c oxidase assembly factor 4
chr19_-_10482874 1.349 ENSMUST00000038842.3
 Ppp1r32
protein phosphatase 1, regulatory subunit 32
chr7_+_100537052 1.336 ENSMUST00000054310.3
 Coa4
cytochrome c oxidase assembly factor 4
chr11_+_98682554 1.332 ENSMUST00000017365.8
 Psmd3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 4.6 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.2 2.7 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 2.7 GO:0051225 spindle assembly(GO:0051225)
0.3 2.6 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 2.3 GO:0043171 peptide catabolic process(GO:0043171)
0.4 2.0 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.3 1.7 GO:0002339 B cell selection(GO:0002339)
0.2 1.7 GO:0060539 diaphragm development(GO:0060539)
0.0 1.7 GO:0016579 protein deubiquitination(GO:0016579)
0.1 1.4 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.1 1.4 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 1.3 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 1.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 1.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 1.1 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.1 1.0 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.0 1.0 GO:0043486 histone exchange(GO:0043486)
0.0 1.0 GO:0034341 response to interferon-gamma(GO:0034341)
0.1 0.7 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 0.6 GO:0006013 mannose metabolic process(GO:0006013)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.9 GO:0042611 MHC protein complex(GO:0042611)
0.2 4.1 GO:0005652 nuclear lamina(GO:0005652)
0.3 2.7 GO:0070652 HAUS complex(GO:0070652)
0.0 2.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 2.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.4 GO:0031526 brush border membrane(GO:0031526)
0.1 1.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.3 GO:0036038 MKS complex(GO:0036038)
0.0 1.1 GO:0005643 nuclear pore(GO:0005643)
0.0 1.0 GO:0016235 aggresome(GO:0016235)
0.0 1.0 GO:0005876 spindle microtubule(GO:0005876)
0.2 0.8 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.5 GO:0042825 TAP complex(GO:0042825)
0.0 0.5 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.2 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.1 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.7 GO:0042605 peptide antigen binding(GO:0042605)
0.6 2.3 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 2.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.5 2.0 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.2 1.7 GO:0015197 peptide transporter activity(GO:0015197)
0.0 1.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.3 1.4 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 1.4 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.4 1.3 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 1.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.0 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.0 GO:0030145 manganese ion binding(GO:0030145)
0.0 1.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.8 GO:0070628 proteasome binding(GO:0070628)
0.1 0.7 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.6 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.2 0.5 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.3 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 2.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.4 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 2.6 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 2.3 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 2.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3 2.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 2.1 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.1 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.5 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.5 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.5 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.4 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network