Motif ID: Rfx5

Z-value: 1.047


Transcription factors associated with Rfx5:

Gene SymbolEntrez IDGene Name
Rfx5 ENSMUSG00000005774.6 Rfx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_94954226-0.428.3e-02Click!


Activity profile for motif Rfx5.

activity profile for motif Rfx5


Sorted Z-values histogram for motif Rfx5

Sorted Z-values for motif Rfx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_30664986 2.712 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr2_+_122147680 2.588 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr17_+_35861318 2.329 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr7_-_105752193 2.292 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I
chr7_-_45092130 2.098 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr12_+_108334341 2.059 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr17_+_37270214 2.049 ENSMUST00000038580.6
 H2-M3
histocompatibility 2, M region locus 3
chr7_+_46841475 2.032 ENSMUST00000147535.1
 Ldha
lactate dehydrogenase A
chr17_+_35861343 1.793 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr18_-_51865881 1.693 ENSMUST00000091905.2
 Gm4950
predicted pseudogene 4950
chr17_+_34263209 1.661 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr1_-_183147461 1.651 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr7_-_45091713 1.608 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr8_-_89187560 1.507 ENSMUST00000093326.2
 Gm5356
predicted pseudogene 5356
chr19_-_4615647 1.464 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr17_-_24886304 1.448 ENSMUST00000044252.5
 Nubp2
nucleotide binding protein 2
chr7_+_100537192 1.403 ENSMUST00000120454.1
 Coa4
cytochrome c oxidase assembly factor 4
chr19_-_10482874 1.349 ENSMUST00000038842.3
 Ppp1r32
protein phosphatase 1, regulatory subunit 32
chr7_+_100537052 1.336 ENSMUST00000054310.3
 Coa4
cytochrome c oxidase assembly factor 4
chr11_+_98682554 1.332 ENSMUST00000017365.8
 Psmd3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr4_-_35845204 1.254 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr11_+_61505138 1.253 ENSMUST00000102657.3
 B9d1
B9 protein domain 1
chr11_-_3539228 1.177 ENSMUST00000075118.3
ENSMUST00000136243.1
ENSMUST00000170588.1
ENSMUST00000020721.8
 Smtn



smoothelin



chr8_+_94214567 1.093 ENSMUST00000079961.6
 Nup93
nucleoporin 93
chr4_-_116627921 1.031 ENSMUST00000030456.7
 Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr19_+_37376359 1.017 ENSMUST00000012587.3
 Kif11
kinesin family member 11
chr17_+_34305883 1.008 ENSMUST00000074557.8
 H2-Eb1
histocompatibility 2, class II antigen E beta
chr13_+_24831661 0.986 ENSMUST00000038039.2
 Tdp2
tyrosyl-DNA phosphodiesterase 2
chr2_-_152398046 0.963 ENSMUST00000063332.8
ENSMUST00000182625.1
 Sox12

SRY-box containing gene 12

chr17_+_35439155 0.912 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr17_-_34187219 0.838 ENSMUST00000173831.1
 Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr10_-_7663245 0.833 ENSMUST00000163085.1
ENSMUST00000159917.1
 Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chr7_+_44468020 0.769 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
 Josd2


Josephin domain containing 2


chr11_+_117523526 0.761 ENSMUST00000132261.1
 Gm11734
predicted gene 11734
chr8_+_84969587 0.702 ENSMUST00000109734.1
ENSMUST00000005292.8
 Prdx2

peroxiredoxin 2

chr5_-_36830647 0.611 ENSMUST00000031002.3
 Man2b2
mannosidase 2, alpha B2
chr5_+_139150211 0.608 ENSMUST00000026975.6
 Heatr2
HEAT repeat containing 2
chr17_+_35379608 0.569 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr7_+_44467980 0.566 ENSMUST00000035844.4
 Josd2
Josephin domain containing 2
chr5_-_125294107 0.545 ENSMUST00000127148.1
 Scarb1
scavenger receptor class B, member 1
chr10_-_7663569 0.542 ENSMUST00000162606.1
 Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr17_+_34135182 0.466 ENSMUST00000042121.9
 H2-DMa
histocompatibility 2, class II, locus DMa
chr18_+_60803838 0.464 ENSMUST00000050487.8
ENSMUST00000097563.2
ENSMUST00000167610.1
 Cd74


CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)


chr10_-_19011948 0.432 ENSMUST00000105527.1
 Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr8_-_69996326 0.369 ENSMUST00000177851.1
ENSMUST00000065169.4
 Gatad2a

GATA zinc finger domain containing 2A

chr8_-_85067982 0.357 ENSMUST00000177563.1
 Gm5741
predicted gene 5741
chr3_-_95882031 0.316 ENSMUST00000161994.1
 Gm129
predicted gene 129
chr7_+_101378183 0.315 ENSMUST00000084895.5
 Arap1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr17_+_34187789 0.294 ENSMUST00000041633.8
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr7_+_44468051 0.276 ENSMUST00000118493.1
 Josd2
Josephin domain containing 2
chr3_-_95882193 0.275 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
 Gm129


predicted gene 129


chr7_-_101921186 0.272 ENSMUST00000106965.1
ENSMUST00000106968.1
ENSMUST00000106967.1
 Lrrc51


leucine rich repeat containing 51


chr19_+_32757497 0.256 ENSMUST00000013807.7
 Pten
phosphatase and tensin homolog
chrX_-_160138375 0.254 ENSMUST00000033662.8
 Pdha1
pyruvate dehydrogenase E1 alpha 1
chr1_+_136676413 0.249 ENSMUST00000181491.1
 Gm19705
predicted gene, 19705
chr17_+_24886643 0.245 ENSMUST00000117890.1
ENSMUST00000168265.1
ENSMUST00000120943.1
ENSMUST00000068508.6
ENSMUST00000119829.1
 Spsb3




splA/ryanodine receptor domain and SOCS box containing 3




chr9_-_51102062 0.205 ENSMUST00000170947.1
 4833427G06Rik
RIKEN cDNA 4833427G06 gene
chr7_-_19692596 0.202 ENSMUST00000108451.2
ENSMUST00000045035.4
 Apoc1

apolipoprotein C-I

chr17_+_34187545 0.192 ENSMUST00000170086.1
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr7_-_101921175 0.181 ENSMUST00000098236.2
 Lrrc51
leucine rich repeat containing 51
chr3_+_16183177 0.164 ENSMUST00000108345.2
ENSMUST00000108346.2
 Ythdf3

YTH domain family 3

chr11_+_72441341 0.144 ENSMUST00000045633.5
 Mybbp1a
MYB binding protein (P160) 1a
chr4_+_107968332 0.107 ENSMUST00000106713.3
 Slc1a7
solute carrier family 1 (glutamate transporter), member 7
chr15_+_36179299 0.092 ENSMUST00000047348.3
 Spag1
sperm associated antigen 1
chr10_-_123196916 0.063 ENSMUST00000020334.7
 Usp15
ubiquitin specific peptidase 15
chr6_+_94500313 0.062 ENSMUST00000061118.8
 Slc25a26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
chr14_+_55618023 0.035 ENSMUST00000002395.7
 Rec8
REC8 homolog (yeast)
chr6_-_8259098 0.005 ENSMUST00000012627.4
 Rpa3
replication protein A3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.6 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.4 2.0 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.3 1.7 GO:0002339 B cell selection(GO:0002339)
0.3 2.6 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.3 0.3 GO:1901630 negative regulation of presynaptic membrane organization(GO:1901630)
0.2 0.5 GO:0046967 cytosol to ER transport(GO:0046967)
0.2 1.1 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.2 2.7 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.2 0.5 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.2 1.7 GO:0060539 diaphragm development(GO:0060539)
0.1 0.4 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.1 0.5 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.1 1.0 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 0.4 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.1 0.7 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 1.4 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.1 1.4 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 2.3 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.6 GO:0006013 mannose metabolic process(GO:0006013)
0.0 1.0 GO:0043486 histone exchange(GO:0043486)
0.0 0.3 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 1.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.1 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 2.7 GO:0051225 spindle assembly(GO:0051225)
0.0 1.3 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 1.0 GO:0034341 response to interferon-gamma(GO:0034341)
0.0 1.7 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 1.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.3 GO:0001921 positive regulation of receptor recycling(GO:0001921)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.9 GO:0042611 MHC protein complex(GO:0042611)
0.3 2.7 GO:0070652 HAUS complex(GO:0070652)
0.2 4.1 GO:0005652 nuclear lamina(GO:0005652)
0.2 0.8 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 2.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.3 GO:0036038 MKS complex(GO:0036038)
0.1 0.5 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 2.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.5 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.4 GO:0031526 brush border membrane(GO:0031526)
0.0 1.0 GO:0016235 aggresome(GO:0016235)
0.0 1.0 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.2 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.1 GO:0005643 nuclear pore(GO:0005643)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.5 2.0 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.4 1.3 GO:0008158 hedgehog receptor activity(GO:0008158)
0.3 1.4 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.2 5.7 GO:0042605 peptide antigen binding(GO:0042605)
0.2 0.5 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.2 1.7 GO:0015197 peptide transporter activity(GO:0015197)
0.1 2.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.3 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 0.7 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.3 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 1.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.6 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.8 GO:0070628 proteasome binding(GO:0070628)
0.0 1.4 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.0 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.3 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 1.0 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 1.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.4 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 2.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 2.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 2.3 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 0.5 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.1 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 2.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.5 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.0 1.1 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.3 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.5 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation