Motif ID: Gsx2_Hoxd3_Vax1
Z-value: 0.779
Transcription factors associated with Gsx2_Hoxd3_Vax1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Gsx2 | ENSMUSG00000035946.6 | Gsx2 |
| Hoxd3 | ENSMUSG00000079277.3 | Hoxd3 |
| Vax1 | ENSMUSG00000006270.6 | Vax1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gsx2 | mm10_v2_chr5_+_75075464_75075601 | 0.56 | 1.5e-02 | Click! |
| Vax1 | mm10_v2_chr19_-_59170978_59170978 | 0.51 | 3.1e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.0 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.7 | 2.2 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 0.5 | 1.6 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.4 | 1.3 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
| 0.3 | 1.2 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 0.2 | 0.7 | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
| 0.2 | 0.6 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 0.2 | 0.6 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
| 0.2 | 0.5 | GO:1900149 | positive regulation of Schwann cell migration(GO:1900149) |
| 0.2 | 0.5 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
| 0.2 | 0.5 | GO:0021972 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
| 0.2 | 2.7 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.1 | 0.9 | GO:0014719 | skeletal muscle satellite cell activation(GO:0014719) |
| 0.1 | 1.4 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 0.5 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
| 0.1 | 0.3 | GO:0006059 | hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401) |
| 0.1 | 0.3 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
| 0.1 | 0.4 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.1 | 0.3 | GO:0035553 | oxidative single-stranded RNA demethylation(GO:0035553) |
| 0.1 | 0.2 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
| 0.1 | 0.4 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.1 | 0.3 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.1 | 0.3 | GO:0090310 | negative regulation of methylation-dependent chromatin silencing(GO:0090310) |
| 0.1 | 0.2 | GO:0045575 | basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575) |
| 0.1 | 0.3 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 0.0 | 0.4 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) |
| 0.0 | 0.3 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 0.0 | 0.1 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
| 0.0 | 0.2 | GO:0006421 | asparaginyl-tRNA aminoacylation(GO:0006421) |
| 0.0 | 1.6 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 0.5 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
| 0.0 | 0.2 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
| 0.0 | 0.3 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.0 | 1.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 2.6 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.0 | 0.3 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 0.0 | 2.4 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.1 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 0.0 | 0.2 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.0 | 0.4 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.0 | 0.2 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.0 | 0.1 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
| 0.0 | 0.0 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.0 | 0.3 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.0 | 0.3 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 0.0 | 0.2 | GO:0003215 | cardiac right ventricle morphogenesis(GO:0003215) |
| 0.0 | 0.3 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.0 | 0.1 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.1 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
| 0.0 | 0.1 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.4 | GO:0008623 | CHRAC(GO:0008623) |
| 0.2 | 0.5 | GO:0097637 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
| 0.2 | 0.6 | GO:0060187 | cell pole(GO:0060187) |
| 0.1 | 0.3 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.1 | 1.3 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.1 | 0.5 | GO:0060091 | kinocilium(GO:0060091) |
| 0.1 | 0.7 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.0 | 0.1 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.0 | 2.6 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 0.2 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.0 | 0.9 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.1 | GO:0031673 | H zone(GO:0031673) |
| 0.0 | 0.6 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.0 | 0.3 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 0.4 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 2.4 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.0 | 0.2 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.2 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 0.4 | GO:0060077 | inhibitory synapse(GO:0060077) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.0 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.2 | 1.1 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 1.6 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 0.5 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.1 | 0.3 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.1 | 0.2 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
| 0.1 | 0.5 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
| 0.1 | 1.3 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 0.3 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.1 | 2.2 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 0.3 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 0.1 | 0.6 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 0.5 | GO:0048495 | GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495) |
| 0.1 | 0.3 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.1 | 0.5 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.0 | 1.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 2.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.3 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.0 | 0.5 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 1.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.3 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.0 | 0.1 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.0 | 0.2 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.0 | 0.4 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.0 | 0.3 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.3 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
| 0.0 | 0.6 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.0 | 0.5 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.1 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 0.8 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 2.6 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.2 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.0 | 0.1 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.0 | 0.1 | GO:0043532 | angiostatin binding(GO:0043532) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.1 | 2.6 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 1.4 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.5 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.0 | 2.5 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.5 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 1.4 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 0.5 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.3 | ST_ADRENERGIC | Adrenergic Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.1 | 3.0 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 3.1 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.5 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.5 | REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS | Genes involved in Prolonged ERK activation events |
| 0.0 | 0.2 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 0.1 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 0.3 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.2 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.4 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 0.5 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
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