Motif ID: Gsx2_Hoxd3_Vax1

Z-value: 0.779

Transcription factors associated with Gsx2_Hoxd3_Vax1:

Gene SymbolEntrez IDGene Name
Gsx2 ENSMUSG00000035946.6 Gsx2
Hoxd3 ENSMUSG00000079277.3 Hoxd3
Vax1 ENSMUSG00000006270.6 Vax1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx2mm10_v2_chr5_+_75075464_750756010.561.5e-02Click!
Vax1mm10_v2_chr19_-_59170978_591709780.513.1e-02Click!


Activity profile for motif Gsx2_Hoxd3_Vax1.

activity profile for motif Gsx2_Hoxd3_Vax1


Sorted Z-values histogram for motif Gsx2_Hoxd3_Vax1

Sorted Z-values for motif Gsx2_Hoxd3_Vax1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx2_Hoxd3_Vax1

PNG image of the network

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Top targets:


Showing 1 to 20 of 150 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_25773985 2.645 ENSMUST00000125667.1
 Myo10
myosin X
chr9_-_90255927 2.425 ENSMUST00000144646.1
 Tbc1d2b
TBC1 domain family, member 2B
chr4_+_8690399 2.205 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr15_-_8710409 2.020 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_+_119063429 1.751 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr2_+_109917639 1.649 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr2_-_168767136 1.639 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr12_-_55014329 1.368 ENSMUST00000172875.1
 Baz1a
bromodomain adjacent to zinc finger domain 1A
chr8_-_34965631 1.296 ENSMUST00000033929.4
 Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chrX_+_9885622 1.274 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr14_-_48662740 1.175 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr14_-_100149764 1.014 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr15_-_8710734 0.997 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr13_-_102906046 0.896 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr14_+_48446128 0.881 ENSMUST00000124720.1
 Tmem260
transmembrane protein 260
chr18_+_57142782 0.863 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr13_-_102905740 0.830 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr2_-_168767029 0.798 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr10_-_33995054 0.796 ENSMUST00000164429.1
 Gm17567
predicted gene, 17567
chr2_+_91457501 0.725 ENSMUST00000028689.3
 Lrp4
low density lipoprotein receptor-related protein 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.2 2.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 2.6 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 2.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.7 2.2 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.5 1.6 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 1.6 GO:0051693 actin filament capping(GO:0051693)
0.1 1.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4 1.3 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.0 1.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.3 1.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 0.9 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.2 0.7 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.2 0.6 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 0.6 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.2 0.5 GO:1900149 positive regulation of Schwann cell migration(GO:1900149)
0.2 0.5 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.2 0.5 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.5 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 0.5 GO:0006107 oxaloacetate metabolic process(GO:0006107)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0016459 myosin complex(GO:0016459)
0.0 2.4 GO:0000792 heterochromatin(GO:0000792)
0.3 1.4 GO:0008623 CHRAC(GO:0008623)
0.1 1.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.9 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.7 GO:0016600 flotillin complex(GO:0016600)
0.2 0.6 GO:0060187 cell pole(GO:0060187)
0.0 0.6 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.2 0.5 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 0.5 GO:0060091 kinocilium(GO:0060091)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.3 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.3 GO:0001739 sex chromatin(GO:0001739)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.1 GO:0031673 H zone(GO:0031673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.0 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 2.6 GO:0030507 spectrin binding(GO:0030507)
0.0 2.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 1.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 1.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.6 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.5 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 0.5 GO:0048495 GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495)
0.1 0.5 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.4 GO:0070410 co-SMAD binding(GO:0070410)
0.1 0.3 GO:0035515 oxidative RNA demethylase activity(GO:0035515)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.6 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 2.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.4 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.5 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.3 ST_ADRENERGIC Adrenergic Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 3.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.5 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 0.5 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 0.2 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 0.2 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels