Motif ID: Atf7_E4f1

Z-value: 1.561

Transcription factors associated with Atf7_E4f1:

Gene SymbolEntrez IDGene Name
Atf7 ENSMUSG00000052414.9 Atf7
Atf7 ENSMUSG00000071584.1 Atf7
E4f1 ENSMUSG00000024137.8 E4f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf7mm10_v2_chr15_-_102529025_102529025-0.743.9e-04Click!
E4f1mm10_v2_chr17_-_24455265_24455345-0.551.8e-02Click!


Activity profile for motif Atf7_E4f1.

activity profile for motif Atf7_E4f1


Sorted Z-values histogram for motif Atf7_E4f1

Sorted Z-values for motif Atf7_E4f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf7_E4f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_106458440 7.805 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr6_-_23248264 6.742 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_+_67374116 5.764 ENSMUST00000061322.8
 Mlf1
myeloid leukemia factor 1
chr13_-_23761223 5.566 ENSMUST00000102964.2
 Hist1h4a
histone cluster 1, H4a
chr3_+_67374091 5.289 ENSMUST00000077916.5
 Mlf1
myeloid leukemia factor 1
chr1_+_74791516 5.274 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr9_-_20976762 4.618 ENSMUST00000054197.5
 S1pr2
sphingosine-1-phosphate receptor 2
chr13_+_23531044 4.313 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr12_-_69159109 4.128 ENSMUST00000037023.8
 Rps29
ribosomal protein S29
chr3_-_36571952 4.054 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr11_-_84525514 3.898 ENSMUST00000018842.7
 Lhx1
LIM homeobox protein 1
chr11_+_84525669 3.897 ENSMUST00000126072.1
ENSMUST00000128121.1
 1500016L03Rik

RIKEN cDNA 1500016L03 gene

chr12_+_112644828 3.787 ENSMUST00000021728.4
ENSMUST00000109755.3
 Siva1

SIVA1, apoptosis-inducing factor

chr8_+_116921735 3.720 ENSMUST00000034205.4
 Cenpn
centromere protein N
chr7_-_137314394 3.613 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr17_-_36958437 3.603 ENSMUST00000113669.2
 Znrd1
zinc ribbon domain containing, 1
chr4_+_141301228 3.582 ENSMUST00000006614.2
 Epha2
Eph receptor A2
chr4_+_111720187 3.552 ENSMUST00000084354.3
 Spata6
spermatogenesis associated 6
chr4_-_97584605 3.523 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr17_-_36958206 3.469 ENSMUST00000172823.1
 Znrd1
zinc ribbon domain containing, 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 213 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 12.7 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.5 10.3 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
1.7 10.2 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.8 9.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 8.3 GO:0006412 translation(GO:0006412)
0.2 7.8 GO:0001709 cell fate determination(GO:0001709)
1.9 7.6 GO:0045903 positive regulation of translational fidelity(GO:0045903)
1.1 6.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 6.7 GO:0034508 centromere complex assembly(GO:0034508)
1.1 6.6 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.5 6.4 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.1 6.1 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 5.6 GO:0008380 RNA splicing(GO:0008380)
0.5 5.5 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.9 5.4 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.6 5.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 5.3 GO:0006342 chromatin silencing(GO:0006342)
0.5 5.2 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.5 5.2 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030)
0.1 4.9 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 12.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 12.1 GO:0097546 ciliary base(GO:0097546)
0.1 10.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.6 10.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.3 9.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 9.7 GO:0000776 kinetochore(GO:0000776)
0.6 9.3 GO:0030008 TRAPP complex(GO:0030008)
1.3 9.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 8.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 7.7 GO:0000790 nuclear chromatin(GO:0000790)
0.6 6.6 GO:0005642 annulate lamellae(GO:0005642)
2.0 6.1 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.4 5.7 GO:0016589 NURF complex(GO:0016589)
0.2 4.7 GO:0071011 precatalytic spliceosome(GO:0071011)
0.1 4.4 GO:0015934 large ribosomal subunit(GO:0015934)
0.7 4.1 GO:0098536 deuterosome(GO:0098536)
0.6 4.1 GO:0001940 male pronucleus(GO:0001940)
0.0 3.9 GO:0016607 nuclear speck(GO:0016607)
0.1 3.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 10.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 9.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 9.1 GO:0017160 Ral GTPase binding(GO:0017160)
1.3 7.6 GO:1990932 5.8S rRNA binding(GO:1990932)
0.2 7.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.4 6.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.8 6.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.1 6.1 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.1 5.6 GO:0005109 frizzled binding(GO:0005109)
0.4 5.5 GO:0001618 virus receptor activity(GO:0001618)
0.1 5.5 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 5.4 GO:0042393 histone binding(GO:0042393)
0.2 5.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.4 5.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.5 4.8 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.5 3.9 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 3.9 GO:0031491 nucleosome binding(GO:0031491)
0.1 3.7 GO:0051082 unfolded protein binding(GO:0051082)
0.7 3.6 GO:0032027 myosin light chain binding(GO:0032027)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 6.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 5.0 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 4.2 PID_BARD1_PATHWAY BARD1 signaling events
0.2 3.9 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 3.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 3.6 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 3.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 3.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.2 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2 2.8 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.6 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 2.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 2.0 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 1.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.7 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.5 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.3 ST_STAT3_PATHWAY STAT3 Pathway
0.1 1.3 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.5 12.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.3 12.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 10.9 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.5 9.1 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 8.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 7.7 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 7.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.3 6.6 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 5.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 5.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 4.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 4.6 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.2 4.1 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 3.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 3.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 3.3 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 3.2 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 3.2 REACTOME_KINESINS Genes involved in Kinesins
0.1 3.1 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation