Motif ID: Stat1
Z-value: 0.754
Transcription factors associated with Stat1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Stat1 | ENSMUSG00000026104.8 | Stat1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Stat1 | mm10_v2_chr1_+_52119438_52119499 | -0.22 | 3.8e-01 | Click! |
Top targets:
Showing 1 to 20 of 159 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 56 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.3 | 3.8 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.0 | 2.8 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.7 | 2.7 | GO:0014012 | peripheral nervous system axon regeneration(GO:0014012) |
| 0.0 | 2.7 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.3 | 1.8 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.1 | 1.5 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 1.5 | GO:0034340 | response to type I interferon(GO:0034340) |
| 0.2 | 1.2 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.1 | 1.2 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.1 | 1.1 | GO:0097421 | liver regeneration(GO:0097421) |
| 0.2 | 1.0 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 0.1 | 1.0 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.1 | 1.0 | GO:2000394 | positive regulation of lamellipodium morphogenesis(GO:2000394) |
| 0.1 | 1.0 | GO:1901898 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.0 | 1.0 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.3 | 0.9 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
| 0.0 | 0.9 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.1 | 0.8 | GO:0045059 | positive thymic T cell selection(GO:0045059) |
| 0.2 | 0.7 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 29 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.1 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.2 | 3.9 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.2 | 2.7 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 1.4 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.4 | 1.2 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.2 | 1.2 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.2 | 1.1 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.1 | 1.0 | GO:0070419 | nonhomologous end joining complex(GO:0070419) |
| 0.0 | 1.0 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 0.9 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.1 | 0.9 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.9 | GO:0030673 | axolemma(GO:0030673) |
| 0.2 | 0.8 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.2 | 0.7 | GO:0090537 | CERF complex(GO:0090537) |
| 0.2 | 0.7 | GO:0031673 | H zone(GO:0031673) |
| 0.0 | 0.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.5 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 0.5 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 0.4 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.1 | 0.4 | GO:0070876 | SOSS complex(GO:0070876) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 41 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.6 | 3.9 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.4 | 2.7 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.1 | 2.2 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.6 | 1.8 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 0.0 | 1.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 1.7 | GO:0043492 | ATPase activity, coupled to movement of substances(GO:0043492) |
| 0.1 | 1.5 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 1.2 | GO:0097643 | amylin receptor activity(GO:0097643) |
| 0.1 | 1.1 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 1.0 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.0 | 1.0 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 0.9 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.0 | 0.9 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.2 | 0.8 | GO:0004528 | phosphodiesterase I activity(GO:0004528) |
| 0.0 | 0.8 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.2 | 0.7 | GO:0070615 | nucleosome-dependent ATPase activity(GO:0070615) |
| 0.0 | 0.7 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 0.6 | GO:0070728 | leucine binding(GO:0070728) |
| 0.1 | 0.6 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
Gene overrepresentation in C2:CP category:
Showing 1 to 12 of 12 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.4 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.1 | 2.7 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 1.8 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 1.1 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.1 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 1.0 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.9 | PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 0.9 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 0.7 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
| 0.0 | 0.5 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
| 0.0 | 0.3 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 0.2 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 21 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 3.9 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 3.7 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 1.9 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 1.3 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 1.2 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.0 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 0.9 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.9 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 0.8 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 0.5 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.5 | REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 0.5 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 0.4 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.4 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.4 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_IFNA_SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 0.2 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.2 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.2 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
