Motif ID: Onecut2_Onecut3

Z-value: 0.676

Transcription factors associated with Onecut2_Onecut3:

Gene SymbolEntrez IDGene Name
Onecut2 ENSMUSG00000045991.12 Onecut2
Onecut3 ENSMUSG00000045518.8 Onecut3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut3mm10_v2_chr10_+_80494835_80494873-0.155.6e-01Click!
Onecut2mm10_v2_chr18_+_64340225_64340364-0.068.1e-01Click!


Activity profile for motif Onecut2_Onecut3.

activity profile for motif Onecut2_Onecut3


Sorted Z-values histogram for motif Onecut2_Onecut3

Sorted Z-values for motif Onecut2_Onecut3



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut2_Onecut3

PNG image of the network

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Top targets:


Showing 1 to 20 of 196 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 1.831 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr12_+_109544498 1.651 ENSMUST00000126289.1
 Meg3
maternally expressed 3
chrY_+_897782 1.349 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr16_-_23890805 1.321 ENSMUST00000004480.3
 Sst
somatostatin
chr3_+_136670076 1.130 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr15_-_42676967 1.043 ENSMUST00000022921.5
 Angpt1
angiopoietin 1
chr1_+_10993452 0.999 ENSMUST00000027056.5
 Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr12_+_109545390 0.960 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr10_+_69533761 0.801 ENSMUST00000182884.1
 Ank3
ankyrin 3, epithelial
chr3_+_102010138 0.711 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr7_-_142661858 0.672 ENSMUST00000145896.2
 Igf2
insulin-like growth factor 2
chr4_+_145510759 0.646 ENSMUST00000105742.1
ENSMUST00000136309.1
 Gm13225

predicted gene 13225

chr19_+_60144682 0.627 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr10_-_45470201 0.605 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr17_+_21566988 0.594 ENSMUST00000088787.5
 Zfp948
zinc finger protein 948
chr1_+_167598450 0.540 ENSMUST00000111386.1
ENSMUST00000111384.1
 Rxrg

retinoid X receptor gamma

chr1_-_144177259 0.533 ENSMUST00000111941.1
ENSMUST00000052375.1
 Rgs13

regulator of G-protein signaling 13

chr8_-_109251698 0.523 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr9_-_86695897 0.514 ENSMUST00000034989.8
 Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr17_+_24720063 0.511 ENSMUST00000170715.1
ENSMUST00000054289.6
ENSMUST00000146867.1
 Rps2


ribosomal protein S2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0008340 determination of adult lifespan(GO:0008340)
0.3 1.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 1.5 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.3 1.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 1.0 GO:0030210 heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.0 1.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.9 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.1 0.8 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 0.7 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 0.7 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 0.6 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 0.6 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.5 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.0 0.5 GO:0097421 liver regeneration(GO:0097421)
0.0 0.5 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.5 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 0.5 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.3 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796) positive regulation of thymocyte apoptotic process(GO:0070245)
0.1 0.3 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.5 GO:0005955 calcineurin complex(GO:0005955)
0.0 1.1 GO:0005902 microvillus(GO:0005902)
0.0 0.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.5 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.2 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 0.2 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.2 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.2 GO:0097449 astrocyte projection(GO:0097449)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0005179 hormone activity(GO:0005179)
0.2 1.5 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 1.3 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.1 1.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 1.0 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 0.5 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.5 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.5 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 0.3 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 0.3 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 0.2 GO:0004660 protein farnesyltransferase activity(GO:0004660)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.0 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.1 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.0 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 0.5 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC