Motif ID: Nfkb2

Z-value: 0.666


Transcription factors associated with Nfkb2:

Gene SymbolEntrez IDGene Name
Nfkb2 ENSMUSG00000025225.8 Nfkb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb2mm10_v2_chr19_+_46304709_46304811-0.513.0e-02Click!


Activity profile for motif Nfkb2.

activity profile for motif Nfkb2


Sorted Z-values histogram for motif Nfkb2

Sorted Z-values for motif Nfkb2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfkb2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_74791516 2.553 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr13_-_111490028 2.010 ENSMUST00000091236.4
 Gpbp1
GC-rich promoter binding protein 1
chr13_-_111490111 1.969 ENSMUST00000047627.7
 Gpbp1
GC-rich promoter binding protein 1
chr7_+_29289300 1.546 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr11_-_33147400 1.128 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chrX_+_163909132 1.042 ENSMUST00000033734.7
ENSMUST00000112294.2
 Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr4_-_125127817 0.965 ENSMUST00000036188.7
 Zc3h12a
zinc finger CCCH type containing 12A
chr9_+_55326913 0.765 ENSMUST00000085754.3
ENSMUST00000034862.4
 AI118078

expressed sequence AI118078

chr2_-_32312162 0.745 ENSMUST00000155269.1
 Dnm1
dynamin 1
chr10_+_80702649 0.736 ENSMUST00000095426.3
 Izumo4
IZUMO family member 4
chrX_+_163908982 0.734 ENSMUST00000069041.8
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr11_-_84870646 0.729 ENSMUST00000018547.2
 Ggnbp2
gametogenetin binding protein 2
chr7_+_16309577 0.694 ENSMUST00000002152.6
 Bbc3
BCL2 binding component 3
chr11_+_70657687 0.650 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr19_-_46338632 0.648 ENSMUST00000051234.8
ENSMUST00000167861.1
 Cuedc2

CUE domain containing 2

chr11_-_84870712 0.635 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
 Ggnbp2



gametogenetin binding protein 2



chr2_-_37422869 0.622 ENSMUST00000112936.1
ENSMUST00000112934.1
 Rc3h2

ring finger and CCCH-type zinc finger domains 2

chr14_-_55591077 0.618 ENSMUST00000161807.1
ENSMUST00000111378.3
ENSMUST00000159687.1
 Psme2


proteasome (prosome, macropain) activator subunit 2 (PA28 beta)


chr11_+_70657196 0.602 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
 Eno3



enolase 3, beta muscle



chr11_+_101176041 0.587 ENSMUST00000103109.3
 Cntnap1
contactin associated protein-like 1
chr11_-_84870812 0.526 ENSMUST00000168434.1
 Ggnbp2
gametogenetin binding protein 2
chr17_+_35379608 0.508 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr3_-_116423930 0.496 ENSMUST00000106491.2
 Cdc14a
CDC14 cell division cycle 14A
chr19_+_6341121 0.483 ENSMUST00000025897.6
ENSMUST00000130382.1
 Map4k2

mitogen-activated protein kinase kinase kinase kinase 2

chr3_-_116424007 0.457 ENSMUST00000090464.4
 Cdc14a
CDC14 cell division cycle 14A
chr17_+_35979851 0.455 ENSMUST00000087200.3
 Gnl1
guanine nucleotide binding protein-like 1
chr4_-_42168603 0.444 ENSMUST00000098121.3
 Gm13305
predicted gene 13305
chr14_-_30607808 0.444 ENSMUST00000112207.1
ENSMUST00000112206.1
ENSMUST00000112202.1
ENSMUST00000112203.1
 Prkcd



protein kinase C, delta



chr11_-_84870188 0.442 ENSMUST00000154915.2
 Ggnbp2
gametogenetin binding protein 2
chr12_+_108792946 0.418 ENSMUST00000021692.7
 Yy1
YY1 transcription factor
chr14_-_30626196 0.418 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
 Prkcd


protein kinase C, delta


chr5_-_137531204 0.414 ENSMUST00000150063.2
 Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr2_-_102451792 0.406 ENSMUST00000099678.3
 Fjx1
four jointed box 1 (Drosophila)
chr2_-_3419066 0.372 ENSMUST00000115082.3
 Meig1
meiosis expressed gene 1
chr7_-_34654342 0.371 ENSMUST00000108069.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr5_+_90891234 0.355 ENSMUST00000031327.8
 Cxcl1
chemokine (C-X-C motif) ligand 1
chr1_-_66817536 0.344 ENSMUST00000068168.3
ENSMUST00000113987.1
 Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr17_+_35424842 0.332 ENSMUST00000174699.1
 H2-Q6
histocompatibility 2, Q region locus 6
chr4_+_129985098 0.320 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr2_-_3419019 0.310 ENSMUST00000115084.1
ENSMUST00000115083.1
 Meig1

meiosis expressed gene 1

chr4_+_129984833 0.299 ENSMUST00000120204.1
 Bai2
brain-specific angiogenesis inhibitor 2
chr8_+_108714644 0.294 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3
chr1_+_135133272 0.237 ENSMUST00000167080.1
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr19_+_45015198 0.232 ENSMUST00000179108.1
 Lzts2
leucine zipper, putative tumor suppressor 2
chr17_+_34898931 0.229 ENSMUST00000097342.3
ENSMUST00000013931.5
 Ehmt2

euchromatic histone lysine N-methyltransferase 2

chr5_-_137530990 0.222 ENSMUST00000132525.1
 Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr11_-_70015346 0.220 ENSMUST00000018718.7
ENSMUST00000102574.3
 Acadvl

acyl-Coenzyme A dehydrogenase, very long chain

chr5_+_135887905 0.208 ENSMUST00000005077.6
 Hspb1
heat shock protein 1
chr17_-_34287770 0.206 ENSMUST00000174751.1
ENSMUST00000040655.6
 H2-Aa

histocompatibility 2, class II antigen A, alpha

chr5_+_135887988 0.196 ENSMUST00000111155.1
 Hspb1
heat shock protein 1
chr19_+_7268296 0.178 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr2_+_10153563 0.175 ENSMUST00000026886.7
 Itih5
inter-alpha (globulin) inhibitor H5
chr1_+_167001417 0.165 ENSMUST00000165874.1
 Fam78b
family with sequence similarity 78, member B
chr7_-_101302020 0.159 ENSMUST00000122116.1
ENSMUST00000120267.1
 Atg16l2

autophagy related 16-like 2 (S. cerevisiae)

chr11_-_54962903 0.152 ENSMUST00000108885.1
ENSMUST00000102730.2
ENSMUST00000018482.6
ENSMUST00000108886.1
ENSMUST00000102731.1
 Tnip1




TNFAIP3 interacting protein 1




chr17_+_35262730 0.126 ENSMUST00000172785.1
 H2-D1
histocompatibility 2, D region locus 1
chr5_+_37245792 0.124 ENSMUST00000031004.7
 Crmp1
collapsin response mediator protein 1
chr5_+_110544326 0.095 ENSMUST00000040001.7
 Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr17_-_35980197 0.093 ENSMUST00000055454.7
 Prr3
proline-rich polypeptide 3
chrX_-_7671341 0.075 ENSMUST00000033486.5
 Plp2
proteolipid protein 2
chr1_+_135132693 0.074 ENSMUST00000049449.4
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr2_+_102550012 0.051 ENSMUST00000028612.7
 Pamr1
peptidase domain containing associated with muscle regeneration 1
chr17_+_35866056 0.019 ENSMUST00000122899.1
 Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr3_+_117575268 0.015 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr11_+_77686155 0.012 ENSMUST00000100802.4
ENSMUST00000181023.1
 Nufip2

nuclear fragile X mental retardation protein interacting protein 2

chr14_-_118237016 0.011 ENSMUST00000170662.1
 Sox21
SRY-box containing gene 21

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.3 1.0 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713) negative regulation of interferon-gamma secretion(GO:1902714) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.3 1.1 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.2 2.5 GO:0048733 sebaceous gland development(GO:0048733)
0.2 0.7 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.2 0.9 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.2 0.6 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.1 0.6 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 0.4 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.1 0.1 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
0.1 0.7 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 0.3 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 1.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 0.4 GO:1900150 regulation of defense response to fungus(GO:1900150)
0.1 0.2 GO:0036166 phenotypic switching(GO:0036166)
0.1 0.4 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.1 0.6 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.8 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.0 0.8 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.1 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.0 0.2 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0 1.8 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.0 1.5 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.2 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 0.5 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.2 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.0 0.4 GO:0010842 retina layer formation(GO:0010842)
0.0 1.3 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 1.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.0 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.4 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.7 GO:0043196 varicosity(GO:0043196)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.6 GO:0033270 paranode region of axon(GO:0033270)
0.0 1.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 0.9 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.1 1.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.7 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 1.0 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 0.2 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 1.0 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 2.6 GO:0005109 frizzled binding(GO:0005109)
0.0 1.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 1.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.2 GO:0042605 peptide antigen binding(GO:0042605)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.9 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.7 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 2.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.8 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.4 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.8 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.0 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 3.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.7 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.9 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.0 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.2 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines