Motif ID: Hoxa1

Z-value: 0.826


Transcription factors associated with Hoxa1:

Gene SymbolEntrez IDGene Name
Hoxa1 ENSMUSG00000029844.9 Hoxa1



Activity profile for motif Hoxa1.

activity profile for motif Hoxa1


Sorted Z-values histogram for motif Hoxa1

Sorted Z-values for motif Hoxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa1

PNG image of the network

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Top targets:


Showing 1 to 20 of 97 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_145201829 3.033 ENSMUST00000162220.1
ENSMUST00000031632.8
Zkscan14

zinc finger with KRAB and SCAN domains 14

chr10_+_81628570 2.774 ENSMUST00000153573.1
ENSMUST00000119336.1
Ankrd24

ankyrin repeat domain 24

chr10_+_81628702 2.439 ENSMUST00000129622.1
Ankrd24
ankyrin repeat domain 24
chr2_+_65845833 2.025 ENSMUST00000053910.3
Csrnp3
cysteine-serine-rich nuclear protein 3
chr4_+_119814495 2.012 ENSMUST00000106307.2
Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr17_+_70522083 1.918 ENSMUST00000148486.1
ENSMUST00000133717.1
Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr14_+_70077375 1.606 ENSMUST00000035908.1
Egr3
early growth response 3
chr2_+_65845767 1.534 ENSMUST00000122912.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr13_-_12340723 1.465 ENSMUST00000168193.1
ENSMUST00000110616.1
ENSMUST00000064204.7
Actn2


actinin alpha 2


chr17_+_70522149 1.409 ENSMUST00000140728.1
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chrX_+_110814390 1.388 ENSMUST00000078229.3
Pou3f4
POU domain, class 3, transcription factor 4
chr14_+_66344369 1.273 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
Stmn4



stathmin-like 4



chr17_+_55445375 1.246 ENSMUST00000133899.1
ENSMUST00000086878.3
St6gal2

beta galactoside alpha 2,6 sialyltransferase 2

chr5_-_135573036 1.242 ENSMUST00000004936.6
Ccl24
chemokine (C-C motif) ligand 24
chr14_+_66344296 1.241 ENSMUST00000152093.1
ENSMUST00000074523.6
Stmn4

stathmin-like 4

chr9_-_4796218 1.172 ENSMUST00000027020.6
ENSMUST00000063508.7
ENSMUST00000163309.1
Gria4


glutamate receptor, ionotropic, AMPA4 (alpha 4)


chr15_+_9140527 1.139 ENSMUST00000090380.4
Lmbrd2
LMBR1 domain containing 2
chr17_-_90455872 1.061 ENSMUST00000174337.1
ENSMUST00000172466.1
Nrxn1

neurexin I

chr2_+_163225363 1.003 ENSMUST00000099110.3
ENSMUST00000165937.1
Tox2

TOX high mobility group box family member 2

chr15_+_82252397 0.972 ENSMUST00000136948.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 3.3 GO:0070842 aggresome assembly(GO:0070842)
0.0 2.5 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 2.0 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 1.8 GO:0030279 negative regulation of ossification(GO:0030279)
0.1 1.6 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.4 1.5 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.2 1.4 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.4 1.2 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.1 1.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 1.2 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.3 1.1 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 0.8 GO:0072318 clathrin coat disassembly(GO:0072318)
0.0 0.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 0.7 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.7 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.1 0.7 GO:0043084 penile erection(GO:0043084)
0.1 0.7 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.7 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0 0.6 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 1.5 GO:0005865 striated muscle thin filament(GO:0005865)
0.2 1.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0048787 presynaptic active zone membrane(GO:0048787)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 1.8 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.2 1.5 GO:0031432 thyroid hormone receptor coactivator activity(GO:0030375) titin binding(GO:0031432)
0.1 1.4 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.4 GO:0048018 receptor agonist activity(GO:0048018)
0.2 1.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 1.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 1.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.5 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.5 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.4 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.1 0.4 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.3 GO:0008301 DNA binding, bending(GO:0008301)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.3 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.2 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.1 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 0.9 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 0.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.0 0.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.2 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.1 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII