Motif ID: Klf7

Z-value: 0.578


Transcription factors associated with Klf7:

Gene SymbolEntrez IDGene Name
Klf7 ENSMUSG00000025959.7 Klf7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf7mm10_v2_chr1_-_64121389_64121452-0.253.2e-01Click!


Activity profile for motif Klf7.

activity profile for motif Klf7


Sorted Z-values histogram for motif Klf7

Sorted Z-values for motif Klf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf7

PNG image of the network

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Top targets:


Showing 1 to 20 of 99 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_897782 2.387 ENSMUST00000055032.7
Kdm5d
lysine (K)-specific demethylase 5D
chr12_-_4592927 1.282 ENSMUST00000170816.1
Gm3625
predicted gene 3625
chr6_-_88874597 0.485 ENSMUST00000061262.4
ENSMUST00000140455.1
ENSMUST00000145780.1
Podxl2


podocalyxin-like 2


chr10_+_86705811 0.484 ENSMUST00000061458.7
ENSMUST00000075632.6
BC030307

cDNA sequence BC030307

chr6_-_88875035 0.452 ENSMUST00000145944.1
Podxl2
podocalyxin-like 2
chr3_+_28263205 0.436 ENSMUST00000159236.2
Tnik
TRAF2 and NCK interacting kinase
chr2_+_32775769 0.333 ENSMUST00000066352.5
Ptrh1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr3_+_106721893 0.310 ENSMUST00000106736.2
ENSMUST00000154973.1
ENSMUST00000131330.1
ENSMUST00000150513.1
Lrif1



ligand dependent nuclear receptor interacting factor 1



chr8_+_3621529 0.306 ENSMUST00000156380.2
Pet100
PET100 homolog (S. cerevisiae)
chr5_+_137761680 0.299 ENSMUST00000110983.2
ENSMUST00000031738.4
Tsc22d4

TSC22 domain family, member 4

chr2_-_156312470 0.293 ENSMUST00000079125.6
Scand1
SCAN domain-containing 1
chr6_+_125039760 0.291 ENSMUST00000140131.1
ENSMUST00000032480.7
Ing4

inhibitor of growth family, member 4

chr1_-_23383149 0.289 ENSMUST00000027343.5
Ogfrl1
opioid growth factor receptor-like 1
chr15_-_89196457 0.287 ENSMUST00000078953.7
Dennd6b
DENN/MADD domain containing 6B
chr7_-_28766469 0.280 ENSMUST00000085851.5
ENSMUST00000032815.4
Nfkbib

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

chr19_+_8723478 0.277 ENSMUST00000180819.1
ENSMUST00000181422.1
Snhg1

small nucleolar RNA host gene (non-protein coding) 1

chrX_+_136270253 0.268 ENSMUST00000178632.1
ENSMUST00000053540.4
Ngfrap1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr3_+_106721672 0.268 ENSMUST00000098750.2
ENSMUST00000130105.1
Lrif1

ligand dependent nuclear receptor interacting factor 1

chr2_+_156312589 0.267 ENSMUST00000073942.5
ENSMUST00000109580.1
Cnbd2

cyclic nucleotide binding domain containing 2

chr10_-_86705485 0.258 ENSMUST00000020238.7
Hsp90b1
heat shock protein 90, beta (Grp94), member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.9 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.4 GO:0021852 pyramidal neuron migration(GO:0021852)
0.1 0.4 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.4 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 0.3 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 0.3 GO:1900110 negative regulation of histone H3-K9 dimethylation(GO:1900110)
0.1 0.3 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0 0.3 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.3 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.3 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.3 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.3 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.2 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 0.2 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.1 0.2 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0 0.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.2 GO:0009405 pathogenesis(GO:0009405)
0.0 0.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.2 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.4 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0097255 R2TP complex(GO:0097255)
0.0 0.3 GO:0055037 recycling endosome(GO:0055037)
0.0 0.2 GO:0033010 paranodal junction(GO:0033010)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0097651 phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.0 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)

Gene overrepresentation in molecular_function category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.4 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 0.6 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.3 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 0.3 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.3 GO:0046790 virion binding(GO:0046790)
0.0 0.3 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903)
0.0 0.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0038025 reelin receptor activity(GO:0038025)
0.0 0.1 GO:0097001 ceramide binding(GO:0097001)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.3 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.2 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.2 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated