ISMARA results: Nkx6-2

Motif ID: Nkx6-2

Z-value: 0.544

Transcription factors associated with Nkx6-2:

Gene Symbol	Entrez ID	Gene Name
Nkx6-2	ENSMUSG00000041309.11	Nkx6-2

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Nkx6-2	mm10_v2_chr7_-_139582790_139582808	0.09	7.3e-01	Click!

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Top targets:

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Showing 1 to 20 of 132 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_-_48432723	1.435	ENSMUST00000046549.3	Apobec2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr18_+_57142782	1.221	ENSMUST00000139892.1	Megf10	multiple EGF-like-domains 10
chr16_-_22161450	1.206	ENSMUST00000115379.1	Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2
chr8_-_61902669	1.092	ENSMUST00000121785.1 ENSMUST00000034057.7	Palld	palladin, cytoskeletal associated protein
chr10_+_37139558	1.090	ENSMUST00000062667.3	5930403N24Rik	RIKEN cDNA 5930403N24 gene
chr4_-_97584605	1.063	ENSMUST00000107067.1	E130114P18Rik	RIKEN cDNA E130114P18 gene
chr6_-_144209471	1.005	ENSMUST00000038815.7	Sox5	SRY-box containing gene 5
chr4_-_97584612	0.995	ENSMUST00000107068.2	E130114P18Rik	RIKEN cDNA E130114P18 gene
chr6_-_144209558	0.955	ENSMUST00000111749.1 ENSMUST00000170367.2	Sox5	SRY-box containing gene 5
chr5_+_92809372	0.865	ENSMUST00000113054.2	Shroom3	shroom family member 3
chr5_+_92683625	0.849	ENSMUST00000168878.1	Shroom3	shroom family member 3
chr6_-_144209448	0.745	ENSMUST00000077160.5	Sox5	SRY-box containing gene 5
chr1_+_184034381	0.663	ENSMUST00000048655.7	Dusp10	dual specificity phosphatase 10
chr2_+_3114220	0.587	ENSMUST00000072955.5	Fam171a1	family with sequence similarity 171, member A1
chr12_+_117843873	0.549	ENSMUST00000176735.1 ENSMUST00000177339.1	Cdca7l	cell division cycle associated 7 like
chr15_-_13173607	0.535	ENSMUST00000036439.4	Cdh6	cadherin 6
chr5_+_123142187	0.516	ENSMUST00000174836.1 ENSMUST00000163030.2	Setd1b	SET domain containing 1B
chr10_-_37138863	0.512	ENSMUST00000092584.5	Marcks	myristoylated alanine rich protein kinase C substrate
chr18_-_74207771	0.472	ENSMUST00000040188.8 ENSMUST00000177604.1	Ska1	spindle and kinetochore associated complex subunit 1
chr10_+_26822560	0.460	ENSMUST00000135866.1	Arhgap18	Rho GTPase activating protein 18

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 35 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.7	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	1.7	GO:0002066	columnar/cuboidal epithelial cell development(GO:0002066)
0.5	1.4	GO:0016554	cytidine to uridine editing(GO:0016554)
0.2	1.2	GO:0043654	skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654)
0.1	1.1	GO:0071803	keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
0.1	0.7	GO:0060690	epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.1	0.7	GO:0060266	negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1	0.5	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0	0.5	GO:0051764	actin crosslink formation(GO:0051764)
0.1	0.4	GO:0060478	acrosomal vesicle exocytosis(GO:0060478)
0.1	0.4	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1	0.4	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0	0.4	GO:0042640	anagen(GO:0042640)
0.1	0.3	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1	0.3	GO:0038018	Wnt receptor catabolic process(GO:0038018)
0.1	0.3	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.1	0.3	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.3	GO:0006344	optic cup morphogenesis involved in camera-type eye development(GO:0002072) maintenance of chromatin silencing(GO:0006344)
0.0	0.3	GO:0021785	branchiomotor neuron axon guidance(GO:0021785)
0.1	0.2	GO:0060023	soft palate development(GO:0060023)

Gene overrepresentation in cellular_component category:

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Showing 1 to 19 of 19 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.1	GO:0044798	nuclear transcription factor complex(GO:0044798)
0.0	1.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	1.1	GO:0002102	podosome(GO:0002102)
0.1	0.7	GO:0005915	zonula adherens(GO:0005915)
0.2	0.5	GO:0042585	germinal vesicle(GO:0042585)
0.0	0.5	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.5	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.4	GO:1990023	mitotic spindle midzone(GO:1990023)
0.0	0.4	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.0	0.4	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.0	0.4	GO:0035371	microtubule plus-end(GO:0035371)
0.0	0.3	GO:0071564	npBAF complex(GO:0071564)
0.0	0.2	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.0	0.2	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0	0.2	GO:0090543	Flemming body(GO:0090543)
0.0	0.2	GO:0005642	annulate lamellae(GO:0005642)
0.0	0.2	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.2	GO:0046930	pore complex(GO:0046930)
0.0	0.1	GO:0030015	CCR4-NOT core complex(GO:0030015)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 26 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.4	GO:0051015	actin filament binding(GO:0051015)
0.4	1.4	GO:0004126	cytidine deaminase activity(GO:0004126)
0.2	1.2	GO:0001849	complement component C1q binding(GO:0001849)
0.0	1.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.7	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) mitogen-activated protein kinase p38 binding(GO:0048273)
0.1	0.5	GO:0033883	pyridoxal phosphatase activity(GO:0033883)
0.0	0.5	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.5	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.0	0.4	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	0.4	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.4	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.4	GO:0001786	phosphatidylserine binding(GO:0001786)
0.1	0.3	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.3	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.3	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.3	GO:0043522	leucine zipper domain binding(GO:0043522)
0.1	0.2	GO:0004822	isoleucine-tRNA ligase activity(GO:0004822)
0.1	0.2	GO:0031871	proteinase activated receptor binding(GO:0031871)
0.0	0.2	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.0	0.2	GO:0005049	nuclear export signal receptor activity(GO:0005049)

Gene overrepresentation in C2:CP category:

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Showing 1 to 5 of 5 entries

Total log-likelihood	Term	Description
1.5	PID_AJDISS_2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.8	PID_NFAT_TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.7	PID_P38_ALPHA_BETA_PATHWAY	Regulation of p38-alpha and p38-beta
0.3	PID_EPHRINB_REV_PATHWAY	Ephrin B reverse signaling
0.2	PID_RANBP2_PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 7 of 7 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	0.5	REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.5	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.4	REACTOME_KINESINS	Genes involved in Kinesins
0.0	0.3	REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	0.2	REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.2	REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition