Motif ID: Meis2

Z-value: 1.547


Transcription factors associated with Meis2:

Gene SymbolEntrez IDGene Name
Meis2 ENSMUSG00000027210.14 Meis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Meis2mm10_v2_chr2_-_116065798_1160658530.832.1e-05Click!


Activity profile for motif Meis2.

activity profile for motif Meis2


Sorted Z-values histogram for motif Meis2

Sorted Z-values for motif Meis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Meis2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_128058962 6.001 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr7_+_48959089 5.207 ENSMUST00000183659.1
 Nav2
neuron navigator 2
chr15_-_100599864 3.878 ENSMUST00000177247.2
ENSMUST00000177505.2
 Pou6f1

POU domain, class 6, transcription factor 1

chr9_-_121495678 3.741 ENSMUST00000035120.4
 Cck
cholecystokinin
chr6_-_121081589 3.404 ENSMUST00000077159.5
 Mical3
microtubule associated monooxygenase, calponin and LIM domain containing 3
chr17_+_8924109 3.209 ENSMUST00000149440.1
 Pde10a
phosphodiesterase 10A
chr1_+_156558759 3.109 ENSMUST00000173929.1
 Abl2
v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
chr3_-_127499095 3.099 ENSMUST00000182594.1
 Ank2
ankyrin 2, brain
chr13_+_23934434 3.073 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr19_-_57197435 3.060 ENSMUST00000111550.1
 Ablim1
actin-binding LIM protein 1
chr5_-_25498702 3.022 ENSMUST00000173073.1
ENSMUST00000045291.7
 Kmt2c

lysine (K)-specific methyltransferase 2C

chr19_-_57197496 3.003 ENSMUST00000111544.1
 Ablim1
actin-binding LIM protein 1
chr8_+_120114144 2.949 ENSMUST00000108948.1
ENSMUST00000034281.6
ENSMUST00000108951.1
 6430548M08Rik


RIKEN cDNA 6430548M08 gene


chr19_-_57197377 2.928 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1
chr3_-_82074639 2.924 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr5_-_25498748 2.892 ENSMUST00000173174.1
 Kmt2c
lysine (K)-specific methyltransferase 2C
chr16_+_11322876 2.878 ENSMUST00000180792.1
 Snx29
sorting nexin 29
chr3_-_84270782 2.827 ENSMUST00000054990.4
 Trim2
tripartite motif-containing 2
chr5_-_100159261 2.821 ENSMUST00000139520.1
 Tmem150c
transmembrane protein 150C
chr9_-_114933811 2.805 ENSMUST00000084853.3
 Gpd1l
glycerol-3-phosphate dehydrogenase 1-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.3 5.9 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.4 5.5 GO:0032098 regulation of appetite(GO:0032098)
1.3 5.2 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.1 4.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.7 4.7 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
1.5 4.6 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
0.0 4.3 GO:0008643 carbohydrate transport(GO:0008643)
0.3 3.9 GO:0060363 cranial suture morphogenesis(GO:0060363)
1.3 3.8 GO:0042196 dichloromethane metabolic process(GO:0018900) chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197)
0.7 3.7 GO:1903587 negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.0 3.7 GO:0006342 chromatin silencing(GO:0006342)
0.6 3.5 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 3.5 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 3.4 GO:0030042 actin filament depolymerization(GO:0030042)
0.2 3.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.3 3.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.0 2.9 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.0 2.9 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.4 2.8 GO:0071802 negative regulation of podosome assembly(GO:0071802)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 7.6 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 6.9 GO:0000139 Golgi membrane(GO:0000139)
0.1 6.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.5 5.9 GO:0044666 MLL3/4 complex(GO:0044666)
0.3 5.0 GO:0005614 interstitial matrix(GO:0005614)
0.2 4.7 GO:0001891 phagocytic cup(GO:0001891)
0.9 4.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.5 3.9 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.3 3.7 GO:0043203 axon hillock(GO:0043203)
0.7 3.4 GO:0044316 cone cell pedicle(GO:0044316)
0.1 3.2 GO:0045171 intercellular bridge(GO:0045171)
0.1 3.1 GO:0031430 M band(GO:0031430)
0.2 3.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.6 GO:0002102 podosome(GO:0002102)
0.0 2.6 GO:0043204 perikaryon(GO:0043204)
0.0 2.4 GO:0005901 caveola(GO:0005901)
0.2 2.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 2.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.3 2.1 GO:0005883 neurofilament(GO:0005883)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 GO:0003779 actin binding(GO:0003779)
0.0 6.2 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.3 5.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 5.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.9 4.6 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.2 4.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 4.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 4.5 GO:0030507 spectrin binding(GO:0030507)
0.2 4.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 4.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 4.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
1.3 3.8 GO:0019120 hydrolase activity, acting on acid halide bonds(GO:0016824) hydrolase activity, acting on acid halide bonds, in C-halide compounds(GO:0019120) alkylhalidase activity(GO:0047651)
0.0 3.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 3.7 GO:0071949 FAD binding(GO:0071949)
0.9 3.5 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.9 3.5 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441)
0.3 3.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.5 3.2 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.2 2.9 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 2.9 GO:0005125 cytokine activity(GO:0005125)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 2.3 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.2 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 2.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 1.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.5 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 1.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.4 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.4 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.3 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.6 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 6.1 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 4.7 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 4.6 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 3.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 3.0 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 2.4 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 2.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 2.2 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 2.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.0 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.1 1.9 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.6 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 1.5 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.4 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 1.3 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.0 1.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.0 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis