ISMARA results: Prox1

Motif ID: Prox1

Z-value: 0.704

Transcription factors associated with Prox1:

Gene Symbol	Entrez ID	Gene Name
Prox1	ENSMUSG00000010175.7	Prox1

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Prox1	mm10_v2_chr1_-_190170671_190170744	-0.40	1.0e-01	Click!

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Top targets:

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Showing 1 to 20 of 71 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr19_+_60144682	4.587	ENSMUST00000065383.4	E330013P04Rik	RIKEN cDNA E330013P04 gene
chr5_-_37824580	1.783	ENSMUST00000063116.9	Msx1	msh homeobox 1
chr19_-_15924560	1.391	ENSMUST00000162053.1	Psat1	phosphoserine aminotransferase 1
chr4_-_131821516	1.306	ENSMUST00000097860.2	Ptpru	protein tyrosine phosphatase, receptor type, U
chr19_+_41911851	1.073	ENSMUST00000011896.6	Pgam1	phosphoglycerate mutase 1
chr1_-_169747634	0.935	ENSMUST00000027991.5 ENSMUST00000111357.1	Rgs4	regulator of G-protein signaling 4
chr15_-_80014808	0.808	ENSMUST00000000500.6	Pdgfb	platelet derived growth factor, B polypeptide
chr18_-_20682963	0.770	ENSMUST00000165229.2	Gm10269	predicted gene 10269
chr11_-_115612878	0.763	ENSMUST00000106506.1	Mif4gd	MIF4G domain containing
chr9_+_104569671	0.759	ENSMUST00000057742.8	Cpne4	copine IV
chr6_+_58640536	0.759	ENSMUST00000145161.1 ENSMUST00000114294.1	Abcg2	ATP-binding cassette, sub-family G (WHITE), member 2
chr11_-_115612940	0.757	ENSMUST00000021087.7	Mif4gd	MIF4G domain containing
chr4_+_140701466	0.750	ENSMUST00000038893.5 ENSMUST00000138808.1	Rcc2	regulator of chromosome condensation 2
chr4_+_130913264	0.749	ENSMUST00000156225.1 ENSMUST00000156742.1	Laptm5	lysosomal-associated protein transmembrane 5
chr17_+_27839974	0.651	ENSMUST00000071006.7	Snrpc	U1 small nuclear ribonucleoprotein C
chr4_-_133967235	0.580	ENSMUST00000123234.1	Hmgn2	high mobility group nucleosomal binding domain 2
chr4_-_94556737	0.579	ENSMUST00000030313.8	Caap1	caspase activity and apoptosis inhibitor 1
chr5_+_139252343	0.574	ENSMUST00000130326.1	Get4	golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr5_-_138187177	0.567	ENSMUST00000110937.1 ENSMUST00000139276.1 ENSMUST00000048698.7 ENSMUST00000123415.1	Taf6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr4_+_130913120	0.563	ENSMUST00000151698.1	Laptm5	lysosomal-associated protein transmembrane 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 28 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	1.8	GO:0035880	embryonic nail plate morphogenesis(GO:0035880)
0.3	1.4	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	1.3	GO:0034394	protein localization to cell surface(GO:0034394)
0.4	1.1	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.1	0.9	GO:0036506	maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0	0.9	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.3	0.8	GO:0003104	positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.3	0.8	GO:0019389	urate transport(GO:0015747) glucuronoside metabolic process(GO:0019389) negative regulation of intestinal absorption(GO:1904479)
0.1	0.8	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.1	0.7	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1	0.7	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.0	0.6	GO:0040034	regulation of development, heterochronic(GO:0040034)
0.2	0.5	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0	0.5	GO:0006783	heme biosynthetic process(GO:0006783)
0.1	0.4	GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1	0.4	GO:0061537	glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0	0.4	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.4	GO:0002082	regulation of oxidative phosphorylation(GO:0002082)
0.0	0.4	GO:0048671	negative regulation of collateral sprouting(GO:0048671)
0.1	0.3	GO:0006106	fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)

Gene overrepresentation in cellular_component category:

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Showing 1 to 10 of 10 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1	0.8	GO:1990023	mitotic spindle midzone(GO:1990023)
0.1	0.7	GO:0000243	commitment complex(GO:0000243)
0.0	0.7	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.6	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.0	0.5	GO:0005921	gap junction(GO:0005921)
0.0	0.4	GO:0031011	Ino80 complex(GO:0031011)
0.0	0.2	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.2	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:1902636	kinociliary basal body(GO:1902636)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 20 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	GO:0002039	p53 binding(GO:0002039)
0.1	1.4	GO:0008483	transaminase activity(GO:0008483)
0.0	1.3	GO:0008013	beta-catenin binding(GO:0008013)
0.4	1.1	GO:0046538	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0	0.9	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.2	0.8	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.1	0.8	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.8	GO:0048365	Rac GTPase binding(GO:0048365)
0.1	0.7	GO:1990446	U1 snRNP binding(GO:1990446)
0.0	0.7	GO:0070300	phosphatidic acid binding(GO:0070300)
0.1	0.6	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.2	0.5	GO:0016748	succinyltransferase activity(GO:0016748)
0.1	0.5	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0	0.4	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	0.4	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1	0.3	GO:0001729	ceramide kinase activity(GO:0001729)
0.1	0.3	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1	0.3	GO:0047134	protein-disulfide reductase activity(GO:0047134)
0.0	0.3	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.2	GO:1990188	euchromatin binding(GO:1990188)

Gene overrepresentation in C2:CP category:

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Showing 1 to 5 of 5 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	ST_TYPE_I_INTERFERON_PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.8	PID_S1P_S1P1_PATHWAY	S1P1 pathway
0.0	0.8	PID_HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.7	PID_PI3KCI_AKT_PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.5	PID_HNF3B_PATHWAY	FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 14 of 14 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	1.1	REACTOME_GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	1.1	REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.9	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	Genes involved in G alpha (z) signalling events
0.1	0.8	REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.7	REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.0	0.6	REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0	0.5	REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.5	REACTOME_METABOLISM_OF_PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.4	REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.4	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	0.4	REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0	0.2	REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.2	REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)