Motif ID: Pitx3

Z-value: 0.967


Transcription factors associated with Pitx3:

Gene SymbolEntrez IDGene Name
Pitx3 ENSMUSG00000025229.9 Pitx3



Activity profile for motif Pitx3.

activity profile for motif Pitx3


Sorted Z-values histogram for motif Pitx3

Sorted Z-values for motif Pitx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_62899118 3.057 ENSMUST00000174189.1
 Tet1
tet methylcytosine dioxygenase 1
chr16_+_17276291 2.852 ENSMUST00000164950.1
ENSMUST00000159242.1
 Tmem191c

transmembrane protein 191C

chrX_+_7909542 2.301 ENSMUST00000086274.2
 Gm10490
predicted gene 10490
chr11_-_79296906 2.257 ENSMUST00000068448.2
 Gm9964
predicted gene 9964
chr6_+_90550789 2.015 ENSMUST00000130418.1
ENSMUST00000032175.8
 Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr5_+_90759299 2.007 ENSMUST00000031318.4
 Cxcl5
chemokine (C-X-C motif) ligand 5
chr11_-_100770926 1.872 ENSMUST00000139341.1
ENSMUST00000017891.7
 Ghdc

GH3 domain containing

chr5_+_138280538 1.707 ENSMUST00000162245.1
ENSMUST00000161691.1
 Stag3

stromal antigen 3

chr2_+_28506095 1.699 ENSMUST00000074761.4
 Gm10134
predicted gene 10134
chr7_-_79386943 1.607 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr1_+_85575676 1.589 ENSMUST00000178024.1
 G530012D18Rik
RIKEN cDNA G530012D1 gene
chr10_+_81718919 1.536 ENSMUST00000085664.5
 Zfp433
RIKEN cDNA 1700123A16 gene
chr17_-_32189457 1.529 ENSMUST00000087721.3
ENSMUST00000162117.1
 Ephx3

epoxide hydrolase 3

chrX_+_142226765 1.520 ENSMUST00000112916.2
 Nxt2
nuclear transport factor 2-like export factor 2
chr17_-_71460395 1.510 ENSMUST00000180522.1
 Gm4707
predicted gene 4707
chr16_+_17276337 1.462 ENSMUST00000159065.1
ENSMUST00000159494.1
ENSMUST00000159811.1
 Tmem191c


transmembrane protein 191C


chr17_+_49428359 1.424 ENSMUST00000165390.2
ENSMUST00000024797.9
ENSMUST00000173033.1
 Mocs1


molybdenum cofactor synthesis 1


chr3_+_86070915 1.418 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr1_-_153408429 1.413 ENSMUST00000097535.4
 E330020D12Rik
Riken cDNA E330020D12 gene
chr9_+_118506226 1.397 ENSMUST00000084820.4
 Golga4
golgi autoantigen, golgin subfamily a, 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 4.1 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.0 4.1 GO:0001824 blastocyst development(GO:0001824)
0.6 3.4 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.6 3.1 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.5 2.4 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.3 2.4 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.7 2.0 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.7 2.0 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.1 1.9 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.6 1.8 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 1.8 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.4 1.5 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.0 1.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.3 1.4 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.1 1.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.4 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.3 1.3 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.3 1.3 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.1 1.3 GO:0045056 transcytosis(GO:0045056)
0.2 1.2 GO:0044838 cell quiescence(GO:0044838)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 4.1 GO:0000802 transverse filament(GO:0000802)
0.0 2.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 1.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.1 1.1 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.1 1.1 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 1.1 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.9 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.9 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.9 GO:0042588 zymogen granule(GO:0042588)
0.1 0.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.7 GO:0070652 HAUS complex(GO:0070652)
0.1 0.7 GO:0002177 manchette(GO:0002177)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.0 0.7 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.7 GO:0008180 COP9 signalosome(GO:0008180)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.4 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.5 3.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.7 2.0 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.4 2.0 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.2 2.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 1.8 GO:0030275 LRR domain binding(GO:0030275)
0.3 1.6 GO:0019841 retinol binding(GO:0019841)
0.5 1.5 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.0 1.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.4 GO:0042287 MHC protein binding(GO:0042287)
0.1 1.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.4 GO:0070064 proline-rich region binding(GO:0070064)
0.2 1.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 1.3 GO:0019865 immunoglobulin binding(GO:0019865)
0.4 1.1 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.1 1.1 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.1 1.0 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 1.0 GO:0000030 mannosyltransferase activity(GO:0000030)
0.3 0.9 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.5 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.4 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.3 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.6 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.6 ST_GAQ_PATHWAY G alpha q Pathway
0.0 0.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.2 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.1 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 3.5 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 2.8 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 2.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.7 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.5 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.3 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.0 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.0 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 0.8 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.8 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.6 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.5 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.4 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription