Motif ID: Gtf2i_Gtf2f1

Z-value: 3.295

Transcription factors associated with Gtf2i_Gtf2f1:

Gene SymbolEntrez IDGene Name
Gtf2f1 ENSMUSG00000002658.9 Gtf2f1
Gtf2i ENSMUSG00000060261.9 Gtf2i

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gtf2imm10_v2_chr5_-_134314637_1343146760.616.9e-03Click!
Gtf2f1mm10_v2_chr17_-_57011271_57011326-0.194.6e-01Click!


Activity profile for motif Gtf2i_Gtf2f1.

activity profile for motif Gtf2i_Gtf2f1


Sorted Z-values histogram for motif Gtf2i_Gtf2f1

Sorted Z-values for motif Gtf2i_Gtf2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gtf2i_Gtf2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66948419 28.949 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr7_+_44310213 15.421 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr1_-_56971762 14.565 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr5_-_44799643 14.523 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr7_-_78578308 12.981 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chrX_-_104201126 12.441 ENSMUST00000056502.6
ENSMUST00000118314.1
 C77370

expressed sequence C77370

chr15_+_83791939 11.985 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr10_-_127620960 11.145 ENSMUST00000121829.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr4_-_123527648 10.490 ENSMUST00000147228.1
 Macf1
microtubule-actin crosslinking factor 1
chr15_-_79164477 10.351 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr2_-_36105271 9.896 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr10_+_13966268 9.758 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr10_-_127620922 9.459 ENSMUST00000118455.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr13_+_42709482 9.363 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr7_-_78577771 9.230 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr2_-_45112890 9.019 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr16_+_43503607 8.558 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
 Zbtb20


zinc finger and BTB domain containing 20


chr14_-_55116935 8.498 ENSMUST00000022819.5
 Jph4
junctophilin 4
chr12_+_105336922 8.261 ENSMUST00000180503.1
 2810011L19Rik
RIKEN cDNA 2810011L19 gene
chrX_-_104201099 8.076 ENSMUST00000087879.4
 C77370
expressed sequence C77370

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 630 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 35.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
2.6 28.9 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
1.7 25.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
6.2 24.9 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
1.5 23.9 GO:2000821 regulation of grooming behavior(GO:2000821)
3.9 23.7 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.8 23.3 GO:0035640 exploration behavior(GO:0035640)
7.4 22.2 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
3.7 22.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
2.2 22.1 GO:0046959 habituation(GO:0046959)
6.5 19.6 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.3 18.9 GO:0007019 microtubule depolymerization(GO:0007019)
0.4 18.2 GO:0001919 regulation of receptor recycling(GO:0001919)
3.4 17.2 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
1.3 15.7 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.4 14.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 14.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.7 12.1 GO:0032811 negative regulation of epinephrine secretion(GO:0032811)
0.4 11.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
2.3 11.4 GO:1904908 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 230 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 85.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 44.1 GO:0031224 intrinsic component of membrane(GO:0031224)
1.6 43.2 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.4 39.8 GO:0005905 clathrin-coated pit(GO:0005905)
1.1 39.3 GO:0030673 axolemma(GO:0030673)
0.9 34.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 32.9 GO:0005794 Golgi apparatus(GO:0005794)
0.2 24.0 GO:0000118 histone deacetylase complex(GO:0000118)
3.7 22.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
1.7 20.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 18.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 18.6 GO:0005923 bicellular tight junction(GO:0005923)
0.6 17.5 GO:0043194 axon initial segment(GO:0043194)
3.2 16.1 GO:0030314 junctional membrane complex(GO:0030314)
0.4 15.5 GO:0042734 presynaptic membrane(GO:0042734)
0.1 13.7 GO:0000139 Golgi membrane(GO:0000139)
1.2 13.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
2.5 12.4 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.9 12.0 GO:0032279 asymmetric synapse(GO:0032279)
0.8 11.7 GO:1902711 GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 381 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 53.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 42.3 GO:0017124 SH3 domain binding(GO:0017124)
0.7 30.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 29.3 GO:0008017 microtubule binding(GO:0008017)
8.5 25.5 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
4.4 22.2 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.6 21.8 GO:0070412 R-SMAD binding(GO:0070412)
2.2 19.6 GO:0008046 axon guidance receptor activity(GO:0008046)
2.7 19.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
4.1 16.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.2 15.0 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
1.8 14.5 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 13.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 12.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 11.9 GO:0015459 potassium channel regulator activity(GO:0015459)
1.8 10.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
2.6 10.5 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.3 10.4 GO:0070087 chromo shadow domain binding(GO:0070087)
0.2 9.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
1.1 9.8 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 35.7 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.4 29.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.4 20.6 PID_REELIN_PATHWAY Reelin signaling pathway
0.3 19.0 PID_SHP2_PATHWAY SHP2 signaling
0.6 17.3 ST_GA12_PATHWAY G alpha 12 Pathway
0.4 14.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.4 12.7 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.6 12.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 11.8 PID_LKB1_PATHWAY LKB1 signaling events
0.3 10.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 10.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 9.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 9.5 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.5 9.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 8.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.3 8.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 8.1 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 7.6 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 6.9 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 6.8 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 31.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3 19.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.5 19.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.1 16.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
1.4 14.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
1.0 13.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 12.8 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.4 12.0 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 11.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.4 11.0 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.3 9.7 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling
0.3 9.6 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.3 9.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.5 9.0 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.3 7.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4 7.7 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.3 7.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 7.3 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.5 7.1 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.6 7.0 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling