Motif ID: Atf5
Z-value: 0.870
Transcription factors associated with Atf5:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Atf5 | ENSMUSG00000038539.8 | Atf5 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Atf5 | mm10_v2_chr7_-_44815658_44815682 | -0.44 | 6.9e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 4.0 | GO:0010626 | negative regulation of Schwann cell proliferation(GO:0010626) |
0.8 | 3.1 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
0.6 | 3.0 | GO:0034436 | glycoprotein transport(GO:0034436) |
0.6 | 1.7 | GO:1904339 | negative regulation of dopaminergic neuron differentiation(GO:1904339) |
0.4 | 1.7 | GO:1990743 | protein sialylation(GO:1990743) |
0.4 | 1.2 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
0.3 | 2.7 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
0.3 | 1.1 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
0.2 | 0.7 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
0.2 | 0.7 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
0.2 | 0.7 | GO:0021759 | globus pallidus development(GO:0021759) |
0.2 | 0.9 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
0.2 | 0.6 | GO:1902336 | neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336) |
0.2 | 0.8 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
0.2 | 1.5 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
0.2 | 2.9 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
0.2 | 0.8 | GO:1901843 | positive regulation of high voltage-gated calcium channel activity(GO:1901843) |
0.1 | 0.7 | GO:0042701 | progesterone secretion(GO:0042701) |
0.1 | 0.5 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
0.1 | 2.3 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
0.1 | 0.7 | GO:0048341 | paraxial mesoderm formation(GO:0048341) |
0.1 | 0.6 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
0.1 | 1.0 | GO:0010793 | regulation of mRNA export from nucleus(GO:0010793) |
0.1 | 5.1 | GO:0001919 | regulation of receptor recycling(GO:0001919) |
0.1 | 0.9 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
0.1 | 0.6 | GO:0046549 | retinal cone cell development(GO:0046549) |
0.1 | 0.3 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
0.1 | 0.8 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
0.1 | 1.1 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
0.1 | 0.4 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
0.1 | 0.4 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
0.1 | 1.0 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
0.1 | 0.5 | GO:0035989 | tendon development(GO:0035989) |
0.1 | 0.9 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
0.1 | 1.9 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
0.1 | 0.6 | GO:0060536 | cartilage morphogenesis(GO:0060536) |
0.1 | 0.6 | GO:0021940 | positive regulation of cerebellar granule cell precursor proliferation(GO:0021940) |
0.1 | 3.1 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
0.1 | 0.5 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
0.1 | 1.5 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
0.1 | 0.9 | GO:0042297 | vocal learning(GO:0042297) imitative learning(GO:0098596) |
0.1 | 0.2 | GO:0099525 | presynaptic dense core granule exocytosis(GO:0099525) |
0.0 | 0.3 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
0.0 | 1.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
0.0 | 0.1 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
0.0 | 1.2 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
0.0 | 0.7 | GO:0015693 | magnesium ion transport(GO:0015693) |
0.0 | 1.4 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
0.0 | 0.6 | GO:0039703 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
0.0 | 0.1 | GO:0035754 | B cell chemotaxis(GO:0035754) |
0.0 | 0.0 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
0.0 | 0.1 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) |
0.0 | 0.4 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
0.0 | 1.1 | GO:0048286 | lung alveolus development(GO:0048286) |
0.0 | 0.8 | GO:0003170 | heart valve development(GO:0003170) |
0.0 | 1.0 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
0.0 | 0.3 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
0.0 | 0.1 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
0.0 | 0.7 | GO:0060976 | coronary vasculature development(GO:0060976) |
0.0 | 0.1 | GO:0046541 | saliva secretion(GO:0046541) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 3.1 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
0.5 | 4.0 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
0.3 | 5.1 | GO:0043083 | synaptic cleft(GO:0043083) |
0.2 | 3.0 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
0.2 | 1.5 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.2 | 1.7 | GO:1990909 | Wnt signalosome(GO:1990909) |
0.1 | 0.8 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
0.1 | 0.6 | GO:0044308 | axonal spine(GO:0044308) |
0.1 | 1.0 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
0.1 | 0.4 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
0.1 | 1.0 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
0.1 | 0.7 | GO:0032584 | growth cone membrane(GO:0032584) |
0.1 | 2.7 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
0.1 | 0.7 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.1 | 0.9 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
0.0 | 0.5 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
0.0 | 3.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.0 | 0.3 | GO:0097227 | sperm annulus(GO:0097227) |
0.0 | 0.8 | GO:0033270 | paranode region of axon(GO:0033270) |
0.0 | 0.5 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
0.0 | 0.4 | GO:0097542 | ciliary tip(GO:0097542) |
0.0 | 3.4 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.0 | 0.5 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
0.0 | 1.5 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
0.0 | 0.3 | GO:0005922 | connexon complex(GO:0005922) |
0.0 | 0.3 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
0.0 | 0.9 | GO:0044295 | axonal growth cone(GO:0044295) |
0.0 | 0.7 | GO:0005637 | nuclear inner membrane(GO:0005637) |
0.0 | 0.2 | GO:1904949 | ATPase complex(GO:1904949) |
0.0 | 0.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 0.1 | GO:0030478 | actin cap(GO:0030478) |
0.0 | 0.2 | GO:0031045 | dense core granule(GO:0031045) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 3.0 | GO:0034437 | very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437) |
0.7 | 5.1 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
0.4 | 1.2 | GO:0002153 | steroid receptor RNA activator RNA binding(GO:0002153) |
0.3 | 1.7 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
0.3 | 1.1 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
0.3 | 1.5 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.2 | 0.6 | GO:0008502 | melatonin receptor activity(GO:0008502) |
0.2 | 0.6 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
0.1 | 2.5 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
0.1 | 0.5 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
0.1 | 1.4 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
0.1 | 0.9 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
0.1 | 0.5 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.1 | 3.2 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.1 | 3.1 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
0.1 | 1.9 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.1 | 0.7 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
0.1 | 0.5 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
0.0 | 0.2 | GO:0017116 | single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) |
0.0 | 0.8 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
0.0 | 0.8 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.0 | 0.1 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
0.0 | 0.7 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
0.0 | 2.7 | GO:0030276 | clathrin binding(GO:0030276) |
0.0 | 0.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
0.0 | 0.7 | GO:0017160 | Ral GTPase binding(GO:0017160) |
0.0 | 0.7 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 0.7 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
0.0 | 0.9 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.0 | 0.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
0.0 | 0.1 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
0.0 | 1.9 | GO:0005125 | cytokine activity(GO:0005125) |
0.0 | 3.2 | GO:0017137 | Rab GTPase binding(GO:0017137) |
0.0 | 1.0 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.0 | 0.1 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
0.0 | 0.0 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
0.0 | 1.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
0.0 | 0.3 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
0.0 | 1.2 | GO:0005262 | calcium channel activity(GO:0005262) |
0.0 | 0.9 | GO:0035591 | signaling adaptor activity(GO:0035591) |
0.0 | 0.6 | GO:0008528 | G-protein coupled peptide receptor activity(GO:0008528) |
0.0 | 0.6 | GO:0045309 | protein phosphorylated amino acid binding(GO:0045309) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 4.6 | PID_REELIN_PATHWAY | Reelin signaling pathway |
0.0 | 0.6 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
0.0 | 1.2 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
0.0 | 4.8 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.0 | 0.8 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.0 | 0.7 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.0 | 0.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.0 | 0.8 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
0.0 | 0.2 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
0.0 | 0.5 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 0.6 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 7.8 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
0.3 | 3.1 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
0.1 | 2.1 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
0.1 | 0.5 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
0.1 | 1.5 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
0.0 | 0.6 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
0.0 | 0.7 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
0.0 | 0.8 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
0.0 | 0.3 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
0.0 | 1.8 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 0.1 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
0.0 | 0.5 | REACTOME_KINESINS | Genes involved in Kinesins |
0.0 | 0.2 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |