Motif ID: Foxd2

Z-value: 1.236


Transcription factors associated with Foxd2:

Gene SymbolEntrez IDGene Name
Foxd2 ENSMUSG00000055210.3 Foxd2



Activity profile for motif Foxd2.

activity profile for motif Foxd2


Sorted Z-values histogram for motif Foxd2

Sorted Z-values for motif Foxd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd2

PNG image of the network

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Top targets:


Showing 1 to 20 of 105 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_104114088 7.942 ENSMUST00000031249.3
 Sparcl1
SPARC-like 1
chr18_+_37504264 5.031 ENSMUST00000052179.6
 Pcdhb20
protocadherin beta 20
chr10_+_67096456 4.870 ENSMUST00000174317.1
 Jmjd1c
jumonji domain containing 1C
chrX_-_105929206 4.735 ENSMUST00000134381.1
ENSMUST00000154866.1
 Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr3_+_89520152 4.601 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chrX_-_105929333 4.563 ENSMUST00000134507.1
ENSMUST00000137453.1
ENSMUST00000150914.1
 Atrx


alpha thalassemia/mental retardation syndrome X-linked homolog (human)


chr14_+_101840602 4.562 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr14_-_30353468 4.558 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr7_-_61982348 4.267 ENSMUST00000181804.1
ENSMUST00000181187.1
 A330076H08Rik

RIKEN cDNA A330076H08 gene

chr16_+_43508118 3.878 ENSMUST00000114690.1
 Zbtb20
zinc finger and BTB domain containing 20
chr7_-_61982290 3.833 ENSMUST00000180481.1
 A330076H08Rik
RIKEN cDNA A330076H08 gene
chr14_+_101840501 3.571 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr15_+_92597104 3.451 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr14_+_80000292 3.392 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr18_+_37513652 3.344 ENSMUST00000061405.4
 Pcdhb21
protocadherin beta 21
chrX_-_105929397 3.166 ENSMUST00000113573.1
ENSMUST00000130980.1
 Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr18_+_51117754 2.625 ENSMUST00000116639.2
 Prr16
proline rich 16
chr13_+_16014457 2.497 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr17_-_35046726 2.447 ENSMUST00000097338.4
 Msh5
mutS homolog 5 (E. coli)
chr7_-_14562171 2.399 ENSMUST00000181796.1
 Vmn1r90
vomeronasal 1 receptor 90

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 12.5 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.1 9.0 GO:0007416 synapse assembly(GO:0007416)
0.2 6.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.7 4.9 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
1.1 4.6 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 3.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 3.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.4 2.8 GO:0019532 oxalate transport(GO:0019532)
0.1 2.6 GO:0045793 positive regulation of cell size(GO:0045793)
0.5 2.5 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.0 2.5 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.5 2.4 GO:0051026 chiasma assembly(GO:0051026)
0.0 2.4 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.4 2.3 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.4 2.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 2.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 2.0 GO:0032418 lysosome localization(GO:0032418)
0.2 1.6 GO:0030035 microspike assembly(GO:0030035)
0.2 1.6 GO:0046541 saliva secretion(GO:0046541)
0.2 1.4 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 12.5 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.0 9.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 7.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 7.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 6.8 GO:0030175 filopodium(GO:0030175)
0.5 4.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 3.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 3.4 GO:0042581 specific granule(GO:0042581)
0.8 2.5 GO:0043512 inhibin A complex(GO:0043512)
0.2 2.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 2.4 GO:0000795 synaptonemal complex(GO:0000795)
0.0 2.3 GO:0043204 perikaryon(GO:0043204)
0.0 2.2 GO:0030139 endocytic vesicle(GO:0030139)
0.1 2.1 GO:0071564 npBAF complex(GO:0071564)
0.0 1.6 GO:0043034 costamere(GO:0043034)
0.0 1.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.3 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 1.1 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 12.5 GO:0015616 DNA translocase activity(GO:0015616)
0.1 7.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 6.7 GO:0042805 actinin binding(GO:0042805)
0.0 6.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 4.9 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
1.2 4.6 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.6 4.6 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 3.2 GO:0051015 actin filament binding(GO:0051015)
0.3 2.8 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.4 2.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 2.4 GO:0030983 mismatched DNA binding(GO:0030983)
0.6 2.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 2.3 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.2 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 1.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.2 1.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 1.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 1.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.5 PID_ALK1_PATHWAY ALK1 signaling events
0.1 2.3 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 2.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 2.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.4 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.4 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.7 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.7 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.6 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.5 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.5 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.0 4.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.2 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.6 2.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 2.4 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 2.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.4 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 1.2 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.1 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.0 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.7 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.2 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 0.2 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.1 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)