Motif ID: Hif1a

Z-value: 0.902


Transcription factors associated with Hif1a:

Gene SymbolEntrez IDGene Name
Hif1a ENSMUSG00000021109.7 Hif1a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hif1amm10_v2_chr12_+_73907904_73907970-0.635.1e-03Click!


Activity profile for motif Hif1a.

activity profile for motif Hif1a


Sorted Z-values histogram for motif Hif1a

Sorted Z-values for motif Hif1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hif1a

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_25610533 3.199 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr7_+_46845832 2.659 ENSMUST00000048209.9
ENSMUST00000092621.4
 Ldha

lactate dehydrogenase A

chr7_-_30973399 2.526 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr11_-_89302545 2.496 ENSMUST00000061728.3
 Nog
noggin
chr7_-_30973367 2.353 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr2_+_27886416 2.167 ENSMUST00000028280.7
 Col5a1
collagen, type V, alpha 1
chr4_-_55532453 2.088 ENSMUST00000132746.1
ENSMUST00000107619.2
 Klf4

Kruppel-like factor 4 (gut)

chr16_+_70314087 2.085 ENSMUST00000023393.8
 Gbe1
glucan (1,4-alpha-), branching enzyme 1
chr16_+_70313949 1.922 ENSMUST00000163832.1
 Gbe1
glucan (1,4-alpha-), branching enzyme 1
chr16_+_70314119 1.914 ENSMUST00000170464.2
 Gbe1
glucan (1,4-alpha-), branching enzyme 1
chr1_-_17097839 1.708 ENSMUST00000038382.4
 Jph1
junctophilin 1
chr5_+_129020069 1.696 ENSMUST00000031383.7
ENSMUST00000111343.1
 Ran

RAN, member RAS oncogene family

chrX_-_93832106 1.642 ENSMUST00000045748.6
 Pdk3
pyruvate dehydrogenase kinase, isoenzyme 3
chr14_-_20181773 1.560 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr1_-_153549697 1.537 ENSMUST00000041874.7
 Npl
N-acetylneuraminate pyruvate lyase
chr5_-_135251209 1.532 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr1_+_74771886 1.477 ENSMUST00000006716.6
 Wnt6
wingless-related MMTV integration site 6
chr6_+_88724828 1.470 ENSMUST00000089449.2
 Mgll
monoglyceride lipase
chr5_-_149051604 1.438 ENSMUST00000093196.4
 Hmgb1
high mobility group box 1
chr18_+_74442500 1.278 ENSMUST00000074157.6
 Myo5b
myosin VB

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.0 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.6 4.9 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.1 4.8 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.3 3.2 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.9 2.7 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.5 2.7 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.0 2.6 GO:0006413 translational initiation(GO:0006413)
0.6 2.5 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.3 2.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.7 2.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.7 2.1 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.1 2.0 GO:0009299 mRNA transcription(GO:0009299)
0.5 1.9 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.2 1.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.6 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.5 1.5 GO:1990523 bone regeneration(GO:1990523)
0.5 1.5 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.4 1.5 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.2 1.5 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.2 1.3 GO:0032439 endosome localization(GO:0032439)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.0 GO:0043196 varicosity(GO:0043196)
0.8 4.9 GO:0061689 tricellular tight junction(GO:0061689)
0.2 2.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 2.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.7 2.2 GO:0005588 collagen type V trimer(GO:0005588)
0.2 2.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 2.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 1.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 1.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.6 1.7 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.3 1.7 GO:0030314 junctional membrane complex(GO:0030314)
0.2 1.5 GO:0097452 GAIT complex(GO:0097452)
0.1 1.5 GO:0031527 filopodium membrane(GO:0031527)
0.2 1.3 GO:0045179 apical cortex(GO:0045179)
0.2 1.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 1.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 1.1 GO:0005922 connexon complex(GO:0005922)
0.0 1.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 7.0 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.4 5.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 4.9 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 2.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.9 2.7 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.7 2.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 2.5 GO:0019955 cytokine binding(GO:0019955)
0.1 2.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 2.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 2.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.5 1.9 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.2 1.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 1.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 1.7 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 1.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 1.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.5 1.5 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.4 1.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 1.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.5 GO:0005109 frizzled binding(GO:0005109)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 3.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 2.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.2 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.7 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 1.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 1.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.8 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.6 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.0 REACTOME_GLUCOSE_METABOLISM Genes involved in Glucose metabolism
0.2 5.0 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 4.1 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.0 3.6 REACTOME_TRANSLATION Genes involved in Translation
0.0 3.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 2.7 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 2.3 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 2.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 2.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.1 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.7 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 1.3 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 1.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.2 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.1 1.2 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 1.2 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.1 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 1.1 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.0 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.1 0.7 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions