Motif ID: Nfe2l1_Mafg

Z-value: 1.072

Transcription factors associated with Nfe2l1_Mafg:

Gene SymbolEntrez IDGene Name
Mafg ENSMUSG00000051510.7 Mafg
Mafg ENSMUSG00000053906.4 Mafg
Nfe2l1 ENSMUSG00000038615.11 Nfe2l1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafgmm10_v2_chr11_-_120633594_120633605-0.904.0e-07Click!
Nfe2l1mm10_v2_chr11_-_96829904_96829955-0.341.6e-01Click!


Activity profile for motif Nfe2l1_Mafg.

activity profile for motif Nfe2l1_Mafg


Sorted Z-values histogram for motif Nfe2l1_Mafg

Sorted Z-values for motif Nfe2l1_Mafg



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2l1_Mafg

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 13.167 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_137314394 4.158 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr12_-_10900296 3.397 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr17_+_43952999 3.263 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr17_+_78491549 3.205 ENSMUST00000079363.4
 Gm10093
predicted pseudogene 10093
chr3_+_85915722 3.200 ENSMUST00000054148.7
 Gm9790
predicted gene 9790
chr17_+_70929006 2.845 ENSMUST00000092011.6
 Gm16519
predicted gene, 16519
chrX_-_141874870 2.797 ENSMUST00000182079.1
 Gm15294
predicted gene 15294
chr12_-_54986363 2.718 ENSMUST00000173433.1
ENSMUST00000173803.1
 Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr17_+_93199348 2.702 ENSMUST00000064775.6
 Adcyap1
adenylate cyclase activating polypeptide 1
chr8_+_54077532 2.395 ENSMUST00000033919.4
 Vegfc
vascular endothelial growth factor C
chr14_-_76237353 2.313 ENSMUST00000095471.4
 Rps2-ps6
ribosomal protein S2, pseudogene 6
chr9_-_79977782 2.082 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr2_+_130277157 1.970 ENSMUST00000028890.8
ENSMUST00000159373.1
 Nop56

NOP56 ribonucleoprotein

chr5_+_128601106 1.894 ENSMUST00000117102.2
 Fzd10
frizzled homolog 10 (Drosophila)
chr17_-_48432723 1.890 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr8_+_31091593 1.760 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr9_-_8004585 1.714 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chrX_-_49788204 1.610 ENSMUST00000114893.1
 Igsf1
immunoglobulin superfamily, member 1
chr12_-_56535047 1.557 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 13.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 3.5 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.2 3.3 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.9 2.7 GO:0071649 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274)
0.0 2.7 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.6 2.4 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.1 2.0 GO:0000154 rRNA modification(GO:0000154)
0.6 1.9 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 1.9 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.6 1.8 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.3 1.7 GO:0060242 contact inhibition(GO:0060242)
0.5 1.6 GO:0021759 globus pallidus development(GO:0021759)
0.0 1.5 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 1.5 GO:0007569 cell aging(GO:0007569)
0.3 1.4 GO:0060467 negative regulation of fertilization(GO:0060467)
0.2 1.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 1.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.3 1.3 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
0.2 1.3 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.0 1.3 GO:0022904 respiratory electron transport chain(GO:0022904)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.7 GO:0008623 CHRAC(GO:0008623)
0.3 2.0 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 1.8 GO:0043195 terminal bouton(GO:0043195)
0.6 1.7 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 1.5 GO:0030863 cortical cytoskeleton(GO:0030863)
0.1 1.4 GO:0043196 varicosity(GO:0043196)
0.0 1.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.3 GO:0031985 Golgi cisterna(GO:0031985)
0.3 1.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 1.2 GO:0033503 HULC complex(GO:0033503)
0.1 1.2 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 1.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.0 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 1.0 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 0.9 GO:0071817 MMXD complex(GO:0071817)
0.1 0.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.9 GO:0016460 myosin II complex(GO:0016460)
0.1 0.8 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 0.8 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.8 GO:0008385 IkappaB kinase complex(GO:0008385)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 4.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 4.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 3.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.5 3.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 3.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 2.1 GO:0015197 peptide transporter activity(GO:0015197)
0.1 2.0 GO:1990226 histone methyltransferase binding(GO:1990226)
0.5 1.9 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 1.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.6 1.8 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.2 1.6 GO:0034711 inhibin binding(GO:0034711)
0.1 1.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 1.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 1.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.4 GO:0019843 rRNA binding(GO:0019843)
0.1 1.3 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 1.2 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 2.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 1.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.2 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.8 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.8 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 0.7 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.2 2.4 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 2.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 2.1 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 2.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.5 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.4 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 1.3 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 1.2 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.2 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.1 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.1 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 1.0 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 1.0 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.9 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4