Motif ID: E2f1

Z-value: 5.236


Transcription factors associated with E2f1:

Gene SymbolEntrez IDGene Name
E2f1 ENSMUSG00000027490.11 E2f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f1mm10_v2_chr2_-_154569845_1545698920.911.6e-07Click!


Activity profile for motif E2f1.

activity profile for motif E2f1


Sorted Z-values histogram for motif E2f1

Sorted Z-values for motif E2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_60893430 29.926 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr13_-_23761223 17.492 ENSMUST00000102964.2
 Hist1h4a
histone cluster 1, H4a
chr15_-_98004695 15.416 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr10_-_120476469 14.406 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr5_-_106458440 13.910 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr7_+_65862029 13.895 ENSMUST00000055576.5
ENSMUST00000098391.4
 Pcsk6

proprotein convertase subtilisin/kexin type 6

chr15_-_98004634 13.880 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr12_+_8771317 11.405 ENSMUST00000020911.7
 Sdc1
syndecan 1
chrX_-_52613913 10.397 ENSMUST00000069360.7
 Gpc3
glypican 3
chr1_-_20820213 10.300 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr17_+_56303396 10.251 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr12_+_8771405 9.976 ENSMUST00000171158.1
 Sdc1
syndecan 1
chr17_+_56303321 9.727 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr9_-_97018823 9.417 ENSMUST00000055433.4
 Spsb4
splA/ryanodine receptor domain and SOCS box containing 4
chr10_-_128704978 9.202 ENSMUST00000026416.7
ENSMUST00000026415.7
 Cdk2

cyclin-dependent kinase 2

chr11_+_119022962 9.085 ENSMUST00000026662.7
 Cbx2
chromobox 2
chrX_-_52613936 8.768 ENSMUST00000114857.1
 Gpc3
glypican 3
chr7_+_102441685 8.739 ENSMUST00000033283.9
 Rrm1
ribonucleotide reductase M1
chr12_+_24708241 8.515 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr2_+_163054682 8.389 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 498 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 34.0 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
3.7 33.3 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
1.4 28.6 GO:0006270 DNA replication initiation(GO:0006270)
1.6 28.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.9 28.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
1.3 27.8 GO:0007530 sex determination(GO:0007530)
1.0 24.8 GO:0040034 regulation of development, heterochronic(GO:0040034)
4.3 21.4 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
2.0 20.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
6.4 19.2 GO:0072180 mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
0.9 16.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.6 14.8 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.2 14.1 GO:0006342 chromatin silencing(GO:0006342)
3.5 13.9 GO:0007354 zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.6 13.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
2.6 13.0 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
4.2 12.5 GO:0072284 metanephric S-shaped body morphogenesis(GO:0072284)
1.8 12.5 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.5 12.5 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
2.5 12.3 GO:0045578 negative regulation of B cell differentiation(GO:0045578)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 230 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 110.8 GO:0005634 nucleus(GO:0005634)
0.8 44.7 GO:0000791 euchromatin(GO:0000791)
0.1 42.3 GO:0000228 nuclear chromosome(GO:0000228)
2.7 40.5 GO:0042555 MCM complex(GO:0042555)
1.3 39.9 GO:0000788 nuclear nucleosome(GO:0000788)
2.4 29.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 28.5 GO:0009897 external side of plasma membrane(GO:0009897)
4.5 22.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.6 19.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 18.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 16.6 GO:0000775 chromosome, centromeric region(GO:0000775)
0.7 14.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 12.6 GO:0005681 spliceosomal complex(GO:0005681)
2.1 12.3 GO:0005663 DNA replication factor C complex(GO:0005663)
4.1 12.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
1.2 11.9 GO:0000796 condensin complex(GO:0000796)
0.1 11.9 GO:0005814 centriole(GO:0005814)
3.8 11.5 GO:0033186 CAF-1 complex(GO:0033186)
0.5 11.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.6 11.2 GO:0005652 nuclear lamina(GO:0005652)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 306 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 70.0 GO:0042393 histone binding(GO:0042393)
0.6 32.5 GO:0003678 DNA helicase activity(GO:0003678)
0.8 29.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
5.9 29.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.3 29.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 24.5 GO:0004386 helicase activity(GO:0004386)
0.2 23.2 GO:0001047 core promoter binding(GO:0001047)
5.7 22.8 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
4.5 22.4 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 18.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 18.7 GO:0017025 TBP-class protein binding(GO:0017025)
1.1 18.0 GO:0003680 AT DNA binding(GO:0003680)
0.7 17.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
1.5 16.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.3 14.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 14.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.4 13.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 13.0 GO:0008022 protein C-terminus binding(GO:0008022)
1.5 10.5 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.6 10.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 66.6 PID_E2F_PATHWAY E2F transcription factor network
1.1 48.8 PID_ATR_PATHWAY ATR signaling pathway
0.7 31.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.6 27.7 NABA_COLLAGENS Genes encoding collagen proteins
0.2 26.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.3 23.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 22.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity
1.5 21.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 20.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.4 18.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.5 12.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.4 12.2 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.2 11.0 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2 10.5 PID_CMYB_PATHWAY C-MYB transcription factor network
0.3 8.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.5 6.1 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.2 6.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.7 5.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 5.9 PID_ALK1_PATHWAY ALK1 signaling events
0.2 5.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 68.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
2.0 46.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
2.5 39.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
2.0 33.6 REACTOME_DNA_STRAND_ELONGATION Genes involved in DNA strand elongation
1.8 33.0 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.7 31.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
1.5 26.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 22.3 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 19.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 17.0 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.8 16.9 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.2 16.1 REACTOME_MITOTIC_G2_G2_M_PHASES Genes involved in Mitotic G2-G2/M phases
0.6 15.1 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 11.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS Genes involved in CREB phosphorylation through the activation of Ras
0.3 11.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.2 11.4 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.7 10.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.7 10.3 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.4 9.8 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.6 9.4 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress