Motif ID: Scrt1

Z-value: 2.192


Transcription factors associated with Scrt1:

Gene SymbolEntrez IDGene Name
Scrt1 ENSMUSG00000048385.8 Scrt1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Scrt1mm10_v2_chr15_-_76521902_76522129-0.701.2e-03Click!


Activity profile for motif Scrt1.

activity profile for motif Scrt1


Sorted Z-values histogram for motif Scrt1

Sorted Z-values for motif Scrt1



Network of associatons between targets according to the STRING database.



First level regulatory network of Scrt1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_30973367 12.690 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr7_-_30973399 9.858 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr7_-_30973464 9.249 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr10_+_56377300 8.632 ENSMUST00000068581.7
 Gja1
gap junction protein, alpha 1
chr9_+_91368811 6.938 ENSMUST00000173054.1
 Zic4
zinc finger protein of the cerebellum 4
chr7_-_144939823 6.355 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr14_-_70642268 6.098 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr9_+_91368970 5.953 ENSMUST00000172646.1
 Zic4
zinc finger protein of the cerebellum 4
chr13_-_23991158 5.465 ENSMUST00000021770.7
 Scgn
secretagogin, EF-hand calcium binding protein
chr9_-_27155418 5.429 ENSMUST00000167074.1
ENSMUST00000034472.8
 Jam3

junction adhesion molecule 3

chr15_-_98004634 5.195 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr10_+_26229707 5.087 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr6_+_128375456 4.922 ENSMUST00000100926.2
 4933413G19Rik
RIKEN cDNA 4933413G19 gene
chr1_-_87156127 4.920 ENSMUST00000160810.1
 Ecel1
endothelin converting enzyme-like 1
chr12_-_91779129 4.770 ENSMUST00000170077.1
 Ston2
stonin 2
chr2_+_31950257 4.456 ENSMUST00000001920.7
 Aif1l
allograft inflammatory factor 1-like
chr8_+_31187317 4.233 ENSMUST00000066173.5
ENSMUST00000161788.1
ENSMUST00000110527.2
ENSMUST00000161502.1
 Fut10



fucosyltransferase 10



chrX_-_72274747 4.216 ENSMUST00000064780.3
 Gabre
gamma-aminobutyric acid (GABA) A receptor, subunit epsilon
chr9_-_96862903 3.797 ENSMUST00000121077.1
ENSMUST00000124923.1
 Acpl2

acid phosphatase-like 2

chr2_+_131234043 3.735 ENSMUST00000041362.5
ENSMUST00000110199.2
 Mavs

mitochondrial antiviral signaling protein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.6 31.8 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.6 9.4 GO:0030953 astral microtubule organization(GO:0030953)
2.9 8.6 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.7 7.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.2 6.5 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.9 6.4 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 6.1 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.4 5.9 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.9 5.7 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.6 5.4 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.4 5.2 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.6 5.1 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.1 4.9 GO:0003016 respiratory system process(GO:0003016)
0.4 4.4 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.1 4.3 GO:0018345 protein palmitoylation(GO:0018345)
0.2 4.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.2 3.7 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
1.2 3.7 GO:0002159 desmosome assembly(GO:0002159) adherens junction maintenance(GO:0034334) intermediate filament bundle assembly(GO:0045110) maintenance of organ identity(GO:0048496)
0.7 3.7 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.1 3.7 GO:0050873 brown fat cell differentiation(GO:0050873)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.3 31.8 GO:0061689 tricellular tight junction(GO:0061689)
0.8 8.6 GO:0005916 fascia adherens(GO:0005916)
0.5 7.0 GO:0042555 MCM complex(GO:0042555)
0.1 6.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 6.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 6.1 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 6.1 GO:0016607 nuclear speck(GO:0016607)
0.1 5.8 GO:0005814 centriole(GO:0005814)
0.0 5.7 GO:0005813 centrosome(GO:0005813)
1.1 5.4 GO:0033010 paranodal junction(GO:0033010)
0.4 5.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 4.6 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 4.6 GO:0005884 actin filament(GO:0005884)
0.0 3.9 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.3 3.7 GO:0030057 desmosome(GO:0030057)
0.1 3.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 3.6 GO:0055037 recycling endosome(GO:0055037)
0.0 3.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.9 3.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 3.3 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 32.5 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 10.3 GO:0003924 GTPase activity(GO:0003924)
2.2 8.6 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.1 6.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 6.4 GO:0070064 proline-rich region binding(GO:0070064)
2.0 6.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 5.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.0 5.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 5.1 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 4.7 GO:0005518 collagen binding(GO:0005518)
0.0 4.7 GO:0003735 structural constituent of ribosome(GO:0003735)
1.1 4.2 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.2 4.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.2 4.1 GO:0035198 miRNA binding(GO:0035198)
0.8 3.9 GO:0032027 myosin light chain binding(GO:0032027)
0.2 3.9 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 3.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 3.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.7 3.7 GO:0050700 CARD domain binding(GO:0050700)
0.5 3.7 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 20.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 7.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 7.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 7.0 PID_ATR_PATHWAY ATR signaling pathway
0.1 6.3 NABA_COLLAGENS Genes encoding collagen proteins
0.1 6.1 PID_FGF_PATHWAY FGF signaling pathway
0.4 5.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 4.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 2.6 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 2.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 2.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.4 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 1.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 8.6 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.5 8.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 8.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 6.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.8 6.1 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.3 5.8 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 5.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 5.0 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 4.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.4 4.4 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 3.8 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.3 3.5 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 3.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 2.5 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.3 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 2.2 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.1 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.6 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation