Motif ID: Nr1h4

Z-value: 0.706


Transcription factors associated with Nr1h4:

Gene SymbolEntrez IDGene Name
Nr1h4 ENSMUSG00000047638.9 Nr1h4



Activity profile for motif Nr1h4.

activity profile for motif Nr1h4


Sorted Z-values histogram for motif Nr1h4

Sorted Z-values for motif Nr1h4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1h4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 131 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_50752758 2.176 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr10_+_13966268 1.788 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr4_+_42916647 1.353 ENSMUST00000132173.1
ENSMUST00000107975.1
 N28178

expressed sequence N28178

chr4_+_42917234 1.059 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr7_+_19176416 0.964 ENSMUST00000117338.1
 Eml2
echinoderm microtubule associated protein like 2
chr11_+_101552188 0.951 ENSMUST00000147239.1
 Nbr1
neighbor of Brca1 gene 1
chr1_+_172341197 0.910 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr4_+_133039482 0.851 ENSMUST00000105914.1
 Ahdc1
AT hook, DNA binding motif, containing 1
chr10_+_4611971 0.782 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr4_+_53440388 0.746 ENSMUST00000102911.3
ENSMUST00000107646.2
 Slc44a1

solute carrier family 44, member 1

chr6_+_4902913 0.730 ENSMUST00000175889.1
ENSMUST00000168998.2
 Ppp1r9a

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr7_-_44670820 0.694 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr12_+_86678685 0.667 ENSMUST00000021681.3
 Vash1
vasohibin 1
chr14_+_25459267 0.666 ENSMUST00000007961.8
 Zmiz1
zinc finger, MIZ-type containing 1
chr15_-_98567630 0.646 ENSMUST00000012104.6
 Ccnt1
cyclin T1
chr6_-_124769548 0.634 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr11_+_101552135 0.610 ENSMUST00000103099.1
 Nbr1
neighbor of Brca1 gene 1
chr9_+_54538984 0.578 ENSMUST00000060242.5
ENSMUST00000118413.1
 Sh2d7

SH2 domain containing 7

chrX_+_73064787 0.562 ENSMUST00000060418.6
 Pnma3
paraneoplastic antigen MA3
chr15_+_80287234 0.559 ENSMUST00000160424.1
 Cacna1i
calcium channel, voltage-dependent, alpha 1I subunit

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 2.1 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.3 1.0 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.1 1.0 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.2 0.9 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1 0.9 GO:0007296 vitellogenesis(GO:0007296)
0.2 0.8 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.2 0.8 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.2 0.7 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.1 0.7 GO:0015871 choline transport(GO:0015871)
0.0 0.7 GO:0071625 vocalization behavior(GO:0071625)
0.1 0.6 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.6 GO:0010771 negative regulation of cell morphogenesis involved in differentiation(GO:0010771)
0.2 0.5 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.5 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.1 0.5 GO:1903012 positive regulation of bone development(GO:1903012)
0.1 0.5 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.1 0.5 GO:0006172 ADP biosynthetic process(GO:0006172)
0.1 0.5 GO:0015879 carnitine transport(GO:0015879)
0.0 0.5 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.2 GO:0097512 cardiac myofibril(GO:0097512)
0.1 2.1 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.2 1.0 GO:1990761 growth cone lamellipodium(GO:1990761)
0.1 0.9 GO:0097449 astrocyte projection(GO:0097449)
0.1 0.8 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 0.7 GO:0097513 myosin II filament(GO:0097513)
0.0 0.7 GO:0005776 autophagosome(GO:0005776)
0.1 0.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.6 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 0.5 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.5 GO:0042587 glycogen granule(GO:0042587)
0.0 0.5 GO:0030123 AP-3 adaptor complex(GO:0030123) HOPS complex(GO:0030897)
0.0 0.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.4 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.1 0.4 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.4 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.3 GO:0044194 cytolytic granule(GO:0044194)
0.0 0.3 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.2 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.2 2.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.3 0.9 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.3 0.8 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.8 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.2 0.7 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.6 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.6 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.5 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 0.5 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.5 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 0.4 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 0.4 GO:0009374 biotin binding(GO:0009374)
0.1 0.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.4 GO:0034711 inhibin binding(GO:0034711)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.4 PID_MYC_PATHWAY C-MYC pathway
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 1.1 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.9 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.8 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.7 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.6 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.5 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 0.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 0.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.3 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 0.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins