Motif ID: Wrnip1_Mta3_Rcor1

Z-value: 3.002

Transcription factors associated with Wrnip1_Mta3_Rcor1:

Gene SymbolEntrez IDGene Name
Mta3 ENSMUSG00000055817.11 Mta3
Rcor1 ENSMUSG00000037896.11 Rcor1
Wrnip1 ENSMUSG00000021400.6 Wrnip1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rcor1mm10_v2_chr12_+_111039334_111039400-0.292.4e-01Click!
Mta3mm10_v2_chr17_+_83706170_83706200-0.145.9e-01Click!
Wrnip1mm10_v2_chr13_+_32802007_32802152-0.019.7e-01Click!


Activity profile for motif Wrnip1_Mta3_Rcor1.

activity profile for motif Wrnip1_Mta3_Rcor1


Sorted Z-values histogram for motif Wrnip1_Mta3_Rcor1

Sorted Z-values for motif Wrnip1_Mta3_Rcor1



Network of associatons between targets according to the STRING database.



First level regulatory network of Wrnip1_Mta3_Rcor1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_115994953 7.752 ENSMUST00000015511.8
 Plxnd1
plexin D1
chr16_+_92498122 6.718 ENSMUST00000023670.3
 Clic6
chloride intracellular channel 6
chr2_+_31640037 6.715 ENSMUST00000113470.2
 Prdm12
PR domain containing 12
chr1_-_87156127 6.603 ENSMUST00000160810.1
 Ecel1
endothelin converting enzyme-like 1
chr7_-_34812677 6.230 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr5_+_127241807 6.226 ENSMUST00000119026.1
 Tmem132c
transmembrane protein 132C
chr7_-_66427469 5.929 ENSMUST00000015278.7
 Aldh1a3
aldehyde dehydrogenase family 1, subfamily A3
chr10_-_120476469 5.673 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr7_-_120202104 5.623 ENSMUST00000033198.5
 Crym
crystallin, mu
chr2_+_164562579 5.596 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr4_-_154097105 5.480 ENSMUST00000105643.1
ENSMUST00000133533.1
ENSMUST00000097762.4
 Trp73


transformation related protein 73


chr9_+_107400043 5.238 ENSMUST00000166799.1
ENSMUST00000170737.1
 Cacna2d2

calcium channel, voltage-dependent, alpha 2/delta subunit 2

chr19_+_25610533 4.909 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr1_-_138848576 4.909 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr14_+_122475397 4.881 ENSMUST00000075888.5
 Zic2
zinc finger protein of the cerebellum 2
chr15_-_84447037 4.802 ENSMUST00000080751.2
 1810041L15Rik
RIKEN cDNA 1810041L15 gene
chr18_+_20665250 4.703 ENSMUST00000075312.3
 Ttr
transthyretin
chr7_+_144896523 4.676 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr9_+_107399858 4.484 ENSMUST00000085092.5
ENSMUST00000164988.2
 Cacna2d2

calcium channel, voltage-dependent, alpha 2/delta subunit 2

chr5_-_106458440 4.304 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,469 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.3 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.2 11.1 GO:0002181 cytoplasmic translation(GO:0002181)
2.1 10.5 GO:0070327 thyroid hormone transport(GO:0070327)
2.0 10.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.3 10.2 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
2.0 10.1 GO:0061642 chemoattraction of axon(GO:0061642)
1.7 9.9 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.6 9.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.3 9.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.5 8.8 GO:0021516 dorsal spinal cord development(GO:0021516)
0.2 8.5 GO:0045454 cell redox homeostasis(GO:0045454)
2.8 8.4 GO:0097402 neuroblast migration(GO:0097402)
0.4 8.0 GO:0045116 protein neddylation(GO:0045116)
1.1 7.9 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.9 7.8 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.2 7.7 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
1.5 7.5 GO:1900109 regulation of histone H3-K9 dimethylation(GO:1900109)
1.2 7.4 GO:0048318 axial mesoderm development(GO:0048318)
0.3 7.3 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.8 7.2 GO:1990845 adaptive thermogenesis(GO:1990845)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 498 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 117.1 GO:0043230 extracellular organelle(GO:0043230)
0.1 97.3 GO:0005739 mitochondrion(GO:0005739)
0.0 59.6 GO:0016021 integral component of membrane(GO:0016021)
0.1 34.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 28.6 GO:0005576 extracellular region(GO:0005576)
0.4 26.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 20.8 GO:0015934 large ribosomal subunit(GO:0015934)
0.4 17.6 GO:0044391 ribosomal subunit(GO:0044391)
0.4 14.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.3 13.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 12.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 11.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 11.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.2 9.8 GO:0005643 nuclear pore(GO:0005643)
0.1 8.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 8.1 GO:0005581 collagen trimer(GO:0005581)
0.5 7.8 GO:0031045 dense core granule(GO:0031045)
0.4 7.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 7.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 7.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 748 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 70.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 29.7 GO:0003924 GTPase activity(GO:0003924)
0.5 23.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.8 16.6 GO:0070324 thyroid hormone binding(GO:0070324)
0.4 15.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 15.0 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 14.3 GO:0035326 enhancer binding(GO:0035326)
0.6 14.1 GO:0001222 transcription corepressor binding(GO:0001222)
0.3 13.9 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.4 13.3 GO:0017025 TBP-class protein binding(GO:0017025)
0.2 12.9 GO:0019003 GDP binding(GO:0019003)
1.0 12.6 GO:0001972 retinoic acid binding(GO:0001972)
0.4 12.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.4 11.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.5 11.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 11.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 10.7 GO:0019210 kinase inhibitor activity(GO:0019210)
0.2 10.4 GO:0003743 translation initiation factor activity(GO:0003743)
1.9 9.4 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.5 9.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 133 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 18.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.6 17.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.4 16.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.4 16.0 PID_ALK1_PATHWAY ALK1 signaling events
0.3 15.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 12.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 12.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.3 11.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 11.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.3 11.1 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.4 10.7 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.2 10.0 PID_P73PATHWAY p73 transcription factor network
0.2 9.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 8.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 8.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.3 8.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 8.0 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.2 7.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.5 7.2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 217 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 28.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.4 28.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.4 24.7 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.4 23.3 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.4 20.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.5 18.9 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 18.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5 18.3 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.2 16.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.4 15.0 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 14.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 14.1 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.9 14.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.6 13.6 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2 12.8 REACTOME_AMYLOIDS Genes involved in Amyloids
0.3 12.2 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.5 11.9 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 11.3 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.3 11.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 10.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)