Motif ID: Crem_Jdp2

Z-value: 0.696

Transcription factors associated with Crem_Jdp2:

Gene SymbolEntrez IDGene Name
Crem ENSMUSG00000063889.10 Crem
Jdp2 ENSMUSG00000034271.9 Jdp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cremmm10_v2_chr18_-_3281712_3281747-0.653.5e-03Click!
Jdp2mm10_v2_chr12_+_85599388_85599416-0.107.1e-01Click!


Activity profile for motif Crem_Jdp2.

activity profile for motif Crem_Jdp2


Sorted Z-values histogram for motif Crem_Jdp2

Sorted Z-values for motif Crem_Jdp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Crem_Jdp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_43952999 2.539 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr6_-_23248264 2.500 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr17_+_43953191 2.259 ENSMUST00000044792.4
 Rcan2
regulator of calcineurin 2
chr1_+_74791516 2.226 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr1_-_71653162 2.139 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr15_+_34238026 2.112 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr11_-_84525514 2.053 ENSMUST00000018842.7
 Lhx1
LIM homeobox protein 1
chr9_-_52679429 1.561 ENSMUST00000098768.2
 AI593442
expressed sequence AI593442
chr8_-_24438937 1.543 ENSMUST00000052622.4
 1810011O10Rik
RIKEN cDNA 1810011O10 gene
chr16_-_23890805 1.532 ENSMUST00000004480.3
 Sst
somatostatin
chr9_+_44134562 1.520 ENSMUST00000034650.8
ENSMUST00000098852.2
 Mcam

melanoma cell adhesion molecule

chr4_+_32238950 1.520 ENSMUST00000037416.6
 Bach2
BTB and CNC homology 2
chr11_+_84525669 1.348 ENSMUST00000126072.1
ENSMUST00000128121.1
 1500016L03Rik

RIKEN cDNA 1500016L03 gene

chr1_+_71652837 1.336 ENSMUST00000097699.2
 Apol7d
apolipoprotein L 7d
chr7_+_79500018 1.239 ENSMUST00000182495.1
ENSMUST00000183043.1
 AI854517

expressed sequence AI854517

chr2_+_105668935 1.236 ENSMUST00000142772.1
 Pax6
paired box gene 6
chr4_+_32238713 1.196 ENSMUST00000108180.2
 Bach2
BTB and CNC homology 2
chr14_+_47472628 1.185 ENSMUST00000095941.2
 Fbxo34
F-box protein 34
chr1_-_134079114 1.173 ENSMUST00000020692.6
 Btg2
B cell translocation gene 2, anti-proliferative
chr14_+_47472547 1.160 ENSMUST00000168833.1
ENSMUST00000163324.1
ENSMUST00000043112.7
 Fbxo34


F-box protein 34



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.8 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.4 2.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 2.2 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.7 2.1 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
0.7 2.1 GO:0072284 cervix development(GO:0060067) metanephric S-shaped body morphogenesis(GO:0072284) anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.4 2.0 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.6 1.9 GO:0045204 MAPK export from nucleus(GO:0045204)
0.4 1.5 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0 1.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.5 1.4 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.2 1.4 GO:0055064 carbon dioxide transport(GO:0015670) chloride ion homeostasis(GO:0055064)
0.0 1.4 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.1 1.3 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.1 1.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 1.2 GO:0021542 dentate gyrus development(GO:0021542)
0.0 1.2 GO:0048706 embryonic skeletal system development(GO:0048706)
0.4 1.1 GO:0014028 notochord formation(GO:0014028) axial mesoderm morphogenesis(GO:0048319)
0.3 1.1 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.3 1.1 GO:0042414 epinephrine metabolic process(GO:0042414)
0.1 1.1 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.7 2.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.4 GO:0005643 nuclear pore(GO:0005643)
0.4 1.3 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.2 1.3 GO:0070652 HAUS complex(GO:0070652)
0.1 1.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 1.2 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.2 1.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 1.2 GO:0030008 TRAPP complex(GO:0030008)
0.4 1.1 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2 1.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 1.1 GO:0031045 dense core granule(GO:0031045)
0.0 1.1 GO:0016592 mediator complex(GO:0016592)
0.0 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.0 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 0.9 GO:0071437 invadopodium(GO:0071437)
0.0 0.9 GO:0097546 ciliary base(GO:0097546)
0.2 0.8 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.1 0.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.8 4.8 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 2.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.4 2.1 GO:0045340 mercury ion binding(GO:0045340)
0.3 2.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 2.0 GO:0003680 AT DNA binding(GO:0003680)
0.0 2.0 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 1.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.9 GO:0005109 frizzled binding(GO:0005109)
0.0 1.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.6 GO:0005112 Notch binding(GO:0005112)
0.1 1.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.4 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.2 1.3 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.1 1.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 1.2 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 1.1 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.2 1.1 GO:0035240 dopamine binding(GO:0035240)
0.1 1.1 GO:0001618 virus receptor activity(GO:0001618)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 2.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.1 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.8 ST_STAT3_PATHWAY STAT3 Pathway
0.0 1.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 1.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.1 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.7 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.5 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.5 PID_BARD1_PATHWAY BARD1 signaling events
0.1 0.4 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.4 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.3 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.3 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway
0.0 0.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.2 PID_ATF2_PATHWAY ATF-2 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 2.4 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 2.0 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 1.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.2 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.1 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.1 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.0 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.9 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.7 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 0.5 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation