Motif ID: Zfp423

Z-value: 0.477


Transcription factors associated with Zfp423:

Gene SymbolEntrez IDGene Name
Zfp423 ENSMUSG00000045333.9 Zfp423

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp423mm10_v2_chr8_-_87804411_878044630.184.8e-01Click!


Activity profile for motif Zfp423.

activity profile for motif Zfp423


Sorted Z-values histogram for motif Zfp423

Sorted Z-values for motif Zfp423



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp423

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_22344690 0.639 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr7_-_70360593 0.630 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr12_+_109459843 0.574 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr6_+_6863769 0.537 ENSMUST00000031768.6
 Dlx6
distal-less homeobox 6
chr1_+_167598450 0.536 ENSMUST00000111386.1
ENSMUST00000111384.1
 Rxrg

retinoid X receptor gamma

chr16_+_17489639 0.531 ENSMUST00000023448.6
 Aifm3
apoptosis-inducing factor, mitochondrion-associated 3
chrX_+_58030999 0.459 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chrX_+_58030622 0.446 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr10_+_82954344 0.437 ENSMUST00000095396.3
 Gm4799
predicted gene 4799
chr8_+_58912257 0.413 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr7_+_29307924 0.394 ENSMUST00000108230.1
ENSMUST00000065181.5
 Dpf1

D4, zinc and double PHD fingers family 1

chr1_+_167598384 0.353 ENSMUST00000015987.3
 Rxrg
retinoid X receptor gamma
chr6_+_110645572 0.350 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr10_-_62110945 0.342 ENSMUST00000142821.1
ENSMUST00000124615.1
ENSMUST00000064050.4
ENSMUST00000125704.1
ENSMUST00000142796.1
 2010107G23Rik




RIKEN cDNA 2010107G23 gene




chr4_+_42917234 0.337 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr11_+_11115784 0.331 ENSMUST00000056344.4
 Vwc2
von Willebrand factor C domain containing 2
chr11_-_94474088 0.329 ENSMUST00000107786.1
ENSMUST00000107791.1
ENSMUST00000103166.2
ENSMUST00000107792.1
ENSMUST00000100561.3
ENSMUST00000107793.1
ENSMUST00000107788.1
ENSMUST00000107790.1
ENSMUST00000107789.1
ENSMUST00000107785.1
ENSMUST00000021234.8
 Cacna1g










calcium channel, voltage-dependent, T type, alpha 1G subunit










chr7_-_120670256 0.327 ENSMUST00000033178.2
 Pdzd9
PDZ domain containing 9
chr19_+_6401675 0.304 ENSMUST00000113471.1
ENSMUST00000113469.2
 Rasgrp2

RAS, guanyl releasing protein 2

chr17_-_29347902 0.283 ENSMUST00000095427.4
ENSMUST00000118366.1
 Mtch1

mitochondrial carrier homolog 1 (C. elegans)

chr11_-_33203588 0.273 ENSMUST00000037746.6
 Tlx3
T cell leukemia, homeobox 3
chr4_+_129513581 0.271 ENSMUST00000062356.6
 Marcksl1
MARCKS-like 1
chr1_-_51941261 0.269 ENSMUST00000097103.3
 Gm8420
predicted gene 8420
chr9_-_37552904 0.247 ENSMUST00000065668.5
 Nrgn
neurogranin
chr8_+_27260327 0.239 ENSMUST00000033880.5
 Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr7_-_105744312 0.238 ENSMUST00000141116.1
 Taf10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr2_+_133552159 0.235 ENSMUST00000028836.6
 Bmp2
bone morphogenetic protein 2
chr11_-_115535804 0.213 ENSMUST00000117589.1
ENSMUST00000121185.1
 Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr11_-_106160101 0.210 ENSMUST00000045923.3
 Limd2
LIM domain containing 2
chr12_-_69183986 0.199 ENSMUST00000110620.1
ENSMUST00000110619.1
 Rpl36al

ribosomal protein L36A-like

chr11_-_115536181 0.196 ENSMUST00000118155.1
ENSMUST00000153892.1
 Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr13_-_47106176 0.180 ENSMUST00000021807.6
ENSMUST00000135278.1
 Dek

DEK oncogene (DNA binding)

chr2_+_106693185 0.179 ENSMUST00000111063.1
 Mpped2
metallophosphoesterase domain containing 2
chr4_-_106464167 0.178 ENSMUST00000049507.5
 Pcsk9
proprotein convertase subtilisin/kexin type 9
chrX_+_7822289 0.174 ENSMUST00000009875.4
 Kcnd1
potassium voltage-gated channel, Shal-related family, member 1
chr12_-_69184056 0.168 ENSMUST00000054544.6
 Rpl36al
ribosomal protein L36A-like
chr2_-_180889660 0.165 ENSMUST00000137629.1
 Gm14342
predicted gene 14342
chr2_-_147085445 0.163 ENSMUST00000067020.2
 Nkx2-4
NK2 homeobox 4
chr1_-_54926311 0.158 ENSMUST00000179030.1
ENSMUST00000044359.9
 Ankrd44

ankyrin repeat domain 44

chr7_-_34196608 0.142 ENSMUST00000148381.1
ENSMUST00000002710.3
 Pdcd2l

programmed cell death 2-like

chr7_+_45705518 0.141 ENSMUST00000107740.1
ENSMUST00000107741.1
 Dbp

D site albumin promoter binding protein

chr19_+_10041548 0.141 ENSMUST00000115995.2
 Fads3
fatty acid desaturase 3
chr4_+_129820198 0.132 ENSMUST00000030578.7
 Ptp4a2
protein tyrosine phosphatase 4a2
chr5_-_135934590 0.125 ENSMUST00000055808.5
 Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr11_+_82101836 0.122 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr7_-_105633525 0.117 ENSMUST00000153371.1
ENSMUST00000106789.1
ENSMUST00000057525.7
 Trim3


tripartite motif-containing 3


chr17_+_55986494 0.113 ENSMUST00000011733.8
 Fsd1
fibronectin type 3 and SPRY domain-containing protein
chr13_+_3538075 0.113 ENSMUST00000059515.6
 Gdi2
guanosine diphosphate (GDP) dissociation inhibitor 2
chr17_-_10840285 0.111 ENSMUST00000041463.6
 Pacrg
PARK2 co-regulated
chr2_+_164785994 0.111 ENSMUST00000152471.1
 Snx21
sorting nexin family member 21
chr10_-_14705459 0.110 ENSMUST00000149485.1
ENSMUST00000154132.1
 Vta1

Vps20-associated 1 homolog (S. cerevisiae)

chr6_+_86628174 0.109 ENSMUST00000043400.6
 Asprv1
aspartic peptidase, retroviral-like 1
chr12_+_69184158 0.098 ENSMUST00000060579.8
 Mgat2
mannoside acetylglucosaminyltransferase 2
chr7_-_5014645 0.089 ENSMUST00000165320.1
 Fiz1
Flt3 interacting zinc finger protein 1
chr19_-_10869757 0.089 ENSMUST00000120524.1
ENSMUST00000025645.7
 Tmem132a

transmembrane protein 132A

chr9_+_120492606 0.084 ENSMUST00000007139.4
 Eif1b
eukaryotic translation initiation factor 1B
chr15_-_78718113 0.084 ENSMUST00000088592.4
 Elfn2
leucine rich repeat and fibronectin type III, extracellular 2
chr4_-_148626756 0.079 ENSMUST00000105699.1
 Tardbp
TAR DNA binding protein
chr6_-_124415037 0.063 ENSMUST00000035861.5
ENSMUST00000112532.1
ENSMUST00000080557.5
 Pex5


peroxisomal biogenesis factor 5


chrX_-_75130996 0.057 ENSMUST00000033775.2
 Mpp1
membrane protein, palmitoylated
chr11_+_54902743 0.053 ENSMUST00000082430.3
 Gpx3
glutathione peroxidase 3
chr12_+_102948843 0.050 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr6_-_97205549 0.045 ENSMUST00000164744.1
ENSMUST00000089287.5
 Uba3

ubiquitin-like modifier activating enzyme 3

chr5_+_67260794 0.044 ENSMUST00000161369.1
 Tmem33
transmembrane protein 33
chr14_+_70553687 0.042 ENSMUST00000161069.1
 Hr
hairless
chr16_+_58408443 0.034 ENSMUST00000046663.7
 Dcbld2
discoidin, CUB and LCCL domain containing 2
chr19_+_4231899 0.030 ENSMUST00000025773.3
 Pold4
polymerase (DNA-directed), delta 4
chr8_-_94012558 0.030 ENSMUST00000053766.6
 Amfr
autocrine motility factor receptor
chr2_+_164785823 0.025 ENSMUST00000174070.1
ENSMUST00000172577.1
ENSMUST00000056181.6
 Snx21


sorting nexin family member 21


chr7_+_127485221 0.023 ENSMUST00000048896.6
 Fbrs
fibrosin
chr2_-_30359190 0.021 ENSMUST00000100215.4
ENSMUST00000113620.3
 Sh3glb2

SH3-domain GRB2-like endophilin B2

chr2_-_30359278 0.019 ENSMUST00000163668.2
ENSMUST00000028214.8
ENSMUST00000113621.3
 Sh3glb2


SH3-domain GRB2-like endophilin B2


chr17_+_86963077 0.009 ENSMUST00000024956.8
 Rhoq
ras homolog gene family, member Q
chr17_-_35074485 0.008 ENSMUST00000007259.3
 Ly6g6d
lymphocyte antigen 6 complex, locus G6D

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.2 0.9 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.6 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 0.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 0.2 GO:0060129 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.1 0.4 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.2 GO:0001920 negative regulation of receptor recycling(GO:0001920) negative regulation of low-density lipoprotein particle clearance(GO:0010989) positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)
0.0 0.1 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.0 0.2 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 0.2 GO:0070365 hepatocyte differentiation(GO:0070365)
0.0 0.2 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0 0.6 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 0.9 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.1 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.1 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.3 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.4 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.0 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.0 0.0 GO:0007113 endomitotic cell cycle(GO:0007113)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.2 GO:0000125 PCAF complex(GO:0000125)
0.0 0.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.4 GO:0071565 nBAF complex(GO:0071565)
0.0 0.0 GO:0043625 delta DNA polymerase complex(GO:0043625)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 0.4 GO:0070905 serine binding(GO:0070905)
0.1 0.9 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.3 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.6 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.4 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.1 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.2 GO:0070300 phosphatidic acid binding(GO:0070300)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.2 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway