Motif ID: Hsf1

Z-value: 0.629


Transcription factors associated with Hsf1:

Gene SymbolEntrez IDGene Name
Hsf1 ENSMUSG00000022556.9 Hsf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf1mm10_v2_chr15_+_76477404_76477461-0.503.3e-02Click!


Activity profile for motif Hsf1.

activity profile for motif Hsf1


Sorted Z-values histogram for motif Hsf1

Sorted Z-values for motif Hsf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 119 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48667508 3.049 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr11_-_116335384 1.811 ENSMUST00000036215.7
 Foxj1
forkhead box J1
chr2_+_157560078 1.467 ENSMUST00000153739.2
ENSMUST00000173595.1
ENSMUST00000109526.1
ENSMUST00000173839.1
ENSMUST00000173041.1
ENSMUST00000173793.1
ENSMUST00000172487.1
ENSMUST00000088484.5
 Nnat







neuronatin







chr9_-_103480328 1.417 ENSMUST00000124310.2
 Bfsp2
beaded filament structural protein 2, phakinin
chr7_-_99353104 1.405 ENSMUST00000169437.1
ENSMUST00000094154.4
 Serpinh1

serine (or cysteine) peptidase inhibitor, clade H, member 1

chr6_-_128438673 1.347 ENSMUST00000032508.4
 Fkbp4
FK506 binding protein 4
chr7_-_70366735 1.304 ENSMUST00000089565.5
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr11_+_82911253 1.229 ENSMUST00000164945.1
ENSMUST00000018989.7
 Unc45b

unc-45 homolog B (C. elegans)

chr8_-_45382198 1.124 ENSMUST00000093526.6
 Fam149a
family with sequence similarity 149, member A
chr6_+_128438757 0.994 ENSMUST00000144745.1
 Gm10069
predicted gene 10069
chr12_-_110696332 0.988 ENSMUST00000094361.4
 Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr19_-_7039987 0.988 ENSMUST00000025918.7
 Stip1
stress-induced phosphoprotein 1
chr9_+_40801235 0.980 ENSMUST00000117870.1
ENSMUST00000117557.1
 Hspa8

heat shock protein 8

chr5_-_149636164 0.844 ENSMUST00000076410.4
 Hsph1
heat shock 105kDa/110kDa protein 1
chr11_-_116843449 0.831 ENSMUST00000047616.3
 Jmjd6
jumonji domain containing 6
chr10_+_80826656 0.813 ENSMUST00000060987.8
ENSMUST00000177850.1
ENSMUST00000180036.1
ENSMUST00000179172.1
 Oaz1



ornithine decarboxylase antizyme 1



chr5_-_149636331 0.808 ENSMUST00000074846.7
ENSMUST00000110498.1
ENSMUST00000127977.1
ENSMUST00000132412.1
 Hsph1



heat shock 105kDa/110kDa protein 1



chr5_+_30281377 0.752 ENSMUST00000101448.3
 Drc1
dynein regulatory complex subunit 1
chr4_+_40722461 0.714 ENSMUST00000030118.3
 Dnaja1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr1_+_91250482 0.680 ENSMUST00000171112.1
 Ube2f
ubiquitin-conjugating enzyme E2F (putative)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.2 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.8 3.0 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.5 1.8 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924) negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.4 1.7 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of NK T cell activation(GO:0051135)
0.3 1.6 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.0 1.5 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.2 1.4 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.1 1.4 GO:0070307 lens fiber cell development(GO:0070307)
0.0 1.4 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.3 1.3 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 1.3 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.3 1.0 GO:1903054 protein targeting to vacuole involved in autophagy(GO:0071211) lysosomal membrane organization(GO:0097212) negative regulation of extracellular matrix organization(GO:1903054) positive regulation of protein folding(GO:1903334)
0.1 1.0 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 0.9 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.2 0.8 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 0.8 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.0 0.8 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.2 0.7 GO:0007412 axon target recognition(GO:0007412)
0.1 0.7 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.1 0.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.3 1.6 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.0 1.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.4 GO:0005882 intermediate filament(GO:0005882)
0.0 1.3 GO:0044295 axonal growth cone(GO:0044295)
0.2 1.0 GO:0043202 lysosomal lumen(GO:0043202)
0.1 0.7 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 0.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.6 GO:0015030 Cajal body(GO:0015030)
0.2 0.5 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.3 GO:0097542 ciliary tip(GO:0097542)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 3.0 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 2.2 GO:0051082 unfolded protein binding(GO:0051082)
0.2 1.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 1.4 GO:0002135 CTP binding(GO:0002135)
0.0 1.4 GO:0051879 Hsp90 protein binding(GO:0051879)
0.3 1.3 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 1.3 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.3 1.0 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.1 1.0 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 1.0 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 0.8 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.2 0.8 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.2 0.7 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.1 0.7 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.7 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 0.6 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.4 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.3 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.5 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 2.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.6 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 1.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.2 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 1.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 0.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.5 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.5 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.5 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE