Motif ID: Sox3_Sox10

Z-value: 1.551

Transcription factors associated with Sox3_Sox10:

Gene SymbolEntrez IDGene Name
Sox10 ENSMUSG00000033006.9 Sox10
Sox3 ENSMUSG00000045179.8 Sox3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox3mm10_v2_chrX_-_60893430_60893440-0.728.3e-04Click!
Sox10mm10_v2_chr15_-_79164477_791644960.371.3e-01Click!


Activity profile for motif Sox3_Sox10.

activity profile for motif Sox3_Sox10


Sorted Z-values histogram for motif Sox3_Sox10

Sorted Z-values for motif Sox3_Sox10



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox3_Sox10

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_67586520 7.551 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr11_+_67586675 6.744 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chrX_-_143933089 6.249 ENSMUST00000087313.3
 Dcx
doublecortin
chr18_+_37484955 5.700 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr5_+_66968559 4.777 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr6_-_136171722 4.649 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr2_+_158666690 4.386 ENSMUST00000103116.3
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr4_-_82705735 4.245 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr6_-_13839916 4.110 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr14_-_79771305 4.010 ENSMUST00000039568.5
 Pcdh8
protocadherin 8
chr10_-_29144194 3.942 ENSMUST00000070359.2
 Gm9996
predicted gene 9996
chr4_-_116405986 3.799 ENSMUST00000123072.1
ENSMUST00000144281.1
 Mast2

microtubule associated serine/threonine kinase 2

chr1_+_66321708 3.783 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr18_-_23038656 3.732 ENSMUST00000081423.6
 Nol4
nucleolar protein 4
chr1_+_66322102 3.674 ENSMUST00000123647.1
 Map2
microtubule-associated protein 2
chrX_-_143933204 3.668 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr19_+_44992127 3.657 ENSMUST00000179305.1
 Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr1_+_34579693 3.605 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr17_+_55445550 3.575 ENSMUST00000025000.3
 St6gal2
beta galactoside alpha 2,6 sialyltransferase 2
chr6_+_51432663 3.475 ENSMUST00000005103.5
 Nfe2l3
nuclear factor, erythroid derived 2, like 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 333 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 12.1 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 11.3 GO:0030041 actin filament polymerization(GO:0030041)
0.1 10.7 GO:0007416 synapse assembly(GO:0007416)
0.7 9.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.3 9.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.6 7.6 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 6.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 6.5 GO:0006914 autophagy(GO:0006914)
2.0 6.1 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.4 6.0 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.4 5.6 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.7 5.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3 5.4 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.1 5.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.6 5.0 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.6 4.7 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
1.2 4.6 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.9 4.6 GO:0046684 response to pyrethroid(GO:0046684)
0.9 4.5 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 4.5 GO:0050919 negative chemotaxis(GO:0050919)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 15.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 14.5 GO:0005884 actin filament(GO:0005884)
0.4 13.1 GO:0090544 BAF-type complex(GO:0090544)
1.1 11.3 GO:0045298 tubulin complex(GO:0045298)
0.0 10.0 GO:0005874 microtubule(GO:0005874)
1.0 9.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.5 7.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 5.1 GO:0005871 kinesin complex(GO:0005871)
1.2 5.0 GO:0044307 dendritic branch(GO:0044307)
0.2 5.0 GO:0031430 M band(GO:0031430)
0.3 4.7 GO:0032279 asymmetric synapse(GO:0032279)
0.4 4.6 GO:0043083 synaptic cleft(GO:0043083)
0.3 4.5 GO:1990635 proximal dendrite(GO:1990635)
0.1 4.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 4.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 4.1 GO:0044306 neuron projection terminus(GO:0044306)
0.1 3.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 3.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.6 3.5 GO:0044305 calyx of Held(GO:0044305)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 200 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 25.6 GO:0008017 microtubule binding(GO:0008017)
0.0 18.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.7 12.1 GO:0099609 microtubule lateral binding(GO:0099609)
1.3 10.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 9.8 GO:0003779 actin binding(GO:0003779)
0.4 8.6 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.1 8.5 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 7.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 7.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.5 7.1 GO:0031005 filamin binding(GO:0031005)
0.1 7.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 6.3 GO:0008201 heparin binding(GO:0008201)
2.0 6.1 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
1.2 6.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.3 5.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 5.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 5.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.6 5.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 5.0 GO:0005096 GTPase activator activity(GO:0005096)
0.1 4.9 GO:0030674 protein binding, bridging(GO:0030674)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 12.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 11.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 7.7 PID_LKB1_PATHWAY LKB1 signaling events
0.2 7.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 7.0 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 5.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 4.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 4.0 PID_INSULIN_PATHWAY Insulin Pathway
0.1 3.9 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 3.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 3.3 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 3.2 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 2.6 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 2.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 2.0 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 1.8 PID_ARF6_PATHWAY Arf6 signaling events
0.1 1.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 1.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 1.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.4 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.4 10.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 10.2 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.4 9.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 8.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 6.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 6.5 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 6.0 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 5.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.9 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 4.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 4.8 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.2 3.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.5 3.5 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 3.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.3 3.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 3.0 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 3.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 2.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 2.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway