Motif ID: Foxn1

Z-value: 0.457


Transcription factors associated with Foxn1:

Gene SymbolEntrez IDGene Name
Foxn1 ENSMUSG00000002057.4 Foxn1



Activity profile for motif Foxn1.

activity profile for motif Foxn1


Sorted Z-values histogram for motif Foxn1

Sorted Z-values for motif Foxn1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxn1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_119578981 0.878 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr7_+_123982799 0.807 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr19_+_43612299 0.797 ENSMUST00000057178.9
 Nkx2-3
NK2 homeobox 3
chr10_+_19934472 0.467 ENSMUST00000095806.3
ENSMUST00000120259.1
 Map3k5

mitogen-activated protein kinase kinase kinase 5

chr11_-_69758223 0.409 ENSMUST00000071213.3
 Polr2a
polymerase (RNA) II (DNA directed) polypeptide A
chr13_-_64274879 0.398 ENSMUST00000109770.1
 Cdc14b
CDC14 cell division cycle 14B
chr9_-_45984816 0.382 ENSMUST00000172450.1
 Pafah1b2
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
chr17_+_26561479 0.354 ENSMUST00000167662.1
 Ergic1
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
chr8_-_94012120 0.343 ENSMUST00000143265.1
 Amfr
autocrine motility factor receptor
chr11_-_69758630 0.338 ENSMUST00000058470.9
 Polr2a
polymerase (RNA) II (DNA directed) polypeptide A
chr17_+_47688992 0.305 ENSMUST00000156118.1
 Frs3
fibroblast growth factor receptor substrate 3
chr9_+_21592722 0.304 ENSMUST00000062125.10
 1810026J23Rik
RIKEN cDNA 1810026J23 gene
chr1_-_155099630 0.300 ENSMUST00000055322.4
 Ier5
immediate early response 5
chr19_+_46152505 0.291 ENSMUST00000026254.7
 Gbf1
golgi-specific brefeldin A-resistance factor 1
chr10_+_88379127 0.283 ENSMUST00000127615.1
 Gnptab
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
chr2_-_163645125 0.281 ENSMUST00000017851.3
 Serinc3
serine incorporator 3
chrX_+_151803642 0.278 ENSMUST00000156616.2
 Huwe1
HECT, UBA and WWE domain containing 1
chr8_-_72571033 0.277 ENSMUST00000058733.8
ENSMUST00000167290.1
 Smim7

small integral membrane protein 7

chr11_+_67455339 0.262 ENSMUST00000108681.1
 Gas7
growth arrest specific 7
chr7_+_100372224 0.259 ENSMUST00000051777.8
ENSMUST00000098259.4
 C2cd3

C2 calcium-dependent domain containing 3

chr8_-_111876661 0.243 ENSMUST00000034431.1
 Tmem170
transmembrane protein 170
chrX_+_99136119 0.236 ENSMUST00000052839.6
 Efnb1
ephrin B1
chr6_-_134792596 0.218 ENSMUST00000100857.3
 Dusp16
dual specificity phosphatase 16
chrX_-_23285532 0.208 ENSMUST00000115319.2
 Klhl13
kelch-like 13
chr9_-_106199253 0.207 ENSMUST00000140761.1
 Ppm1m
protein phosphatase 1M
chr6_-_30896735 0.207 ENSMUST00000048774.6
ENSMUST00000166192.1
ENSMUST00000135230.1
 Copg2


coatomer protein complex, subunit gamma 2


chr16_-_96082513 0.206 ENSMUST00000113827.1
 Brwd1
bromodomain and WD repeat domain containing 1
chr7_-_100371889 0.195 ENSMUST00000032963.8
 Ppme1
protein phosphatase methylesterase 1
chrX_-_111463103 0.177 ENSMUST00000137712.2
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chrX_+_101429555 0.177 ENSMUST00000033673.6
 Nono
non-POU-domain-containing, octamer binding protein
chr7_-_133776681 0.168 ENSMUST00000130182.1
ENSMUST00000106139.1
 Dhx32

DEAH (Asp-Glu-Ala-His) box polypeptide 32

chr6_+_113442569 0.168 ENSMUST00000101070.4
 Jagn1
jagunal homolog 1 (Drosophila)
chr2_+_32395896 0.166 ENSMUST00000028162.3
 Ptges2
prostaglandin E synthase 2
chr7_-_133776772 0.164 ENSMUST00000033290.5
 Dhx32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr2_+_4882204 0.163 ENSMUST00000115019.1
 Sephs1
selenophosphate synthetase 1
chr14_-_57746044 0.156 ENSMUST00000173990.1
ENSMUST00000022531.7
 Lats2

large tumor suppressor 2

chr11_-_97744659 0.151 ENSMUST00000018691.8
 Pip4k2b
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr11_+_3290300 0.144 ENSMUST00000057089.6
ENSMUST00000093402.5
 Patz1

POZ (BTB) and AT hook containing zinc finger 1

chr11_+_97362396 0.140 ENSMUST00000045540.3
 Socs7
suppressor of cytokine signaling 7
chr14_+_111675113 0.139 ENSMUST00000042767.7
 Slitrk5
SLIT and NTRK-like family, member 5
chr17_-_80062333 0.138 ENSMUST00000061331.7
 Hnrnpll
heterogeneous nuclear ribonucleoprotein L-like
chr18_+_60526194 0.137 ENSMUST00000025505.5
 Dctn4
dynactin 4
chr6_+_28480337 0.136 ENSMUST00000001460.7
ENSMUST00000167201.1
 Snd1

staphylococcal nuclease and tudor domain containing 1

chr14_+_31251454 0.135 ENSMUST00000022458.4
 Bap1
Brca1 associated protein 1
chrX_+_151803313 0.133 ENSMUST00000026292.8
 Huwe1
HECT, UBA and WWE domain containing 1
chr18_+_32938955 0.133 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr10_+_88379217 0.133 ENSMUST00000130301.1
ENSMUST00000020251.8
 Gnptab

N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

chr19_+_36834215 0.123 ENSMUST00000025729.5
 Tnks2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr2_+_125859134 0.122 ENSMUST00000028636.6
ENSMUST00000125084.1
 Galk2

galactokinase 2

chr1_-_178337774 0.122 ENSMUST00000037748.7
 Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr5_-_115300957 0.120 ENSMUST00000009157.3
 Dynll1
dynein light chain LC8-type 1
chr6_-_85374606 0.118 ENSMUST00000060837.7
 Rab11fip5
RAB11 family interacting protein 5 (class I)
chr15_+_81872309 0.115 ENSMUST00000023116.6
 Aco2
aconitase 2, mitochondrial
chr5_-_115300912 0.113 ENSMUST00000112090.1
 Dynll1
dynein light chain LC8-type 1
chr2_-_44927161 0.109 ENSMUST00000130991.1
 Gtdc1
glycosyltransferase-like domain containing 1
chr7_+_19004047 0.108 ENSMUST00000053713.3
 Irf2bp1
interferon regulatory factor 2 binding protein 1
chr18_-_37935378 0.104 ENSMUST00000025337.7
 Diap1
diaphanous homolog 1 (Drosophila)
chr17_-_80062199 0.103 ENSMUST00000184635.1
 Hnrnpll
heterogeneous nuclear ribonucleoprotein L-like
chr10_-_7681118 0.101 ENSMUST00000159977.1
ENSMUST00000162682.1
 Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chr11_-_87987528 0.099 ENSMUST00000020775.2
 Dynll2
dynein light chain LC8-type 2
chr3_+_152210458 0.097 ENSMUST00000166984.1
ENSMUST00000106121.1
 Fubp1

far upstream element (FUSE) binding protein 1

chr5_-_33936301 0.097 ENSMUST00000030993.6
 Nelfa
negative elongation factor complex member A, Whsc2
chr9_-_64737684 0.095 ENSMUST00000171100.1
ENSMUST00000167569.1
ENSMUST00000004892.6
ENSMUST00000172298.1
 Rab11a



RAB11a, member RAS oncogene family



chr17_-_30576241 0.094 ENSMUST00000079924.5
ENSMUST00000168787.1
 Btbd9

BTB (POZ) domain containing 9

chr7_-_25297967 0.094 ENSMUST00000005583.5
 Pafah1b3
platelet-activating factor acetylhydrolase, isoform 1b, subunit 3
chr19_+_45363734 0.093 ENSMUST00000065601.5
ENSMUST00000111936.2
 Btrc

beta-transducin repeat containing protein

chr9_-_64737623 0.091 ENSMUST00000169058.1
 Rab11a
RAB11a, member RAS oncogene family
chr9_-_110654161 0.088 ENSMUST00000133191.1
ENSMUST00000167320.1
 Nbeal2

neurobeachin-like 2

chr12_-_105685235 0.087 ENSMUST00000041055.7
 Atg2b
autophagy related 2B
chr9_-_21592805 0.086 ENSMUST00000034700.7
ENSMUST00000180365.1
ENSMUST00000078572.7
 Yipf2


Yip1 domain family, member 2


chr8_-_94012558 0.086 ENSMUST00000053766.6
 Amfr
autocrine motility factor receptor
chr4_+_122836236 0.084 ENSMUST00000030412.4
ENSMUST00000121870.1
ENSMUST00000097902.4
 Ppt1


palmitoyl-protein thioesterase 1


chr1_-_65051119 0.082 ENSMUST00000161960.1
ENSMUST00000087359.5
 Cryge

crystallin, gamma E

chr7_+_127588698 0.078 ENSMUST00000033088.6
 Rnf40
ring finger protein 40
chr5_+_21424934 0.076 ENSMUST00000056045.4
 Fam185a
family with sequence similarity 185, member A
chr9_-_72985344 0.071 ENSMUST00000124565.2
 Gm5918
predicted gene 5918
chr2_-_28583189 0.065 ENSMUST00000113889.2
 Gtf3c5
general transcription factor IIIC, polypeptide 5
chr17_+_6106464 0.065 ENSMUST00000142030.1
 Tulp4
tubby like protein 4
chr17_-_29237759 0.063 ENSMUST00000137727.1
ENSMUST00000024805.7
 Cpne5

copine V

chr7_+_133776857 0.062 ENSMUST00000065359.5
ENSMUST00000151031.1
ENSMUST00000121560.1
 Fank1


fibronectin type 3 and ankyrin repeat domains 1


chr7_+_25267669 0.059 ENSMUST00000169266.1
 Cic
capicua homolog (Drosophila)
chr14_-_99099701 0.057 ENSMUST00000042471.9
 Dis3
DIS3 mitotic control homolog (S. cerevisiae)
chrX_+_7841800 0.050 ENSMUST00000033494.9
ENSMUST00000115666.1
 Otud5

OTU domain containing 5

chr13_+_55464237 0.041 ENSMUST00000046533.7
 Prr7
proline rich 7 (synaptic)
chr1_-_59119748 0.040 ENSMUST00000087475.4
 Tmem237
transmembrane protein 237
chr16_-_90727329 0.040 ENSMUST00000099554.4
 Mis18a
MIS18 kinetochore protein homolog A (S. pombe)
chr11_-_100397740 0.039 ENSMUST00000001592.8
ENSMUST00000107403.1
 Jup

junction plakoglobin

chr11_-_104550392 0.038 ENSMUST00000106962.2
 Cdc27
cell division cycle 27
chr1_-_59120079 0.038 ENSMUST00000094917.3
 Tmem237
transmembrane protein 237
chr19_-_36919606 0.038 ENSMUST00000057337.7
 Fgfbp3
fibroblast growth factor binding protein 3
chr7_+_28881656 0.037 ENSMUST00000066880.4
 Capn12
calpain 12
chr8_+_105636509 0.036 ENSMUST00000005841.9
 Ctcf
CCCTC-binding factor
chr5_+_130171798 0.034 ENSMUST00000119797.1
ENSMUST00000148264.1
 Rabgef1

RAB guanine nucleotide exchange factor (GEF) 1

chrX_-_74249819 0.033 ENSMUST00000114299.1
 Flna
filamin, alpha
chr1_+_59119822 0.032 ENSMUST00000180570.1
 G730003C15Rik
RIKEN cDNA G730003C15 gene
chrX_-_111463043 0.031 ENSMUST00000065976.5
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr6_-_32588192 0.031 ENSMUST00000115096.2
 Plxna4
plexin A4
chr7_-_81829431 0.029 ENSMUST00000026093.7
 Btbd1
BTB (POZ) domain containing 1
chr2_+_181497223 0.028 ENSMUST00000108799.3
 Tpd52l2
tumor protein D52-like 2
chr11_-_100738153 0.025 ENSMUST00000155500.1
ENSMUST00000107364.1
ENSMUST00000019317.5
 Rab5c


RAB5C, member RAS oncogene family


chr2_+_181497165 0.020 ENSMUST00000149163.1
ENSMUST00000000844.8
ENSMUST00000184849.1
ENSMUST00000108800.1
ENSMUST00000069712.2
 Tpd52l2




tumor protein D52-like 2




chr4_+_59003121 0.016 ENSMUST00000095070.3
ENSMUST00000174664.1
 Dnajc25
Gm20503
DnaJ (Hsp40) homolog, subfamily C, member 25
predicted gene 20503
chrX_-_74085656 0.016 ENSMUST00000033770.6
 Mecp2
methyl CpG binding protein 2
chrX_-_74085586 0.016 ENSMUST00000123362.1
ENSMUST00000140399.1
ENSMUST00000100750.3
 Mecp2


methyl CpG binding protein 2


chr2_+_131210363 0.010 ENSMUST00000110210.1
ENSMUST00000089506.5
ENSMUST00000110208.1
 Ap5s1


adaptor-related protein 5 complex, sigma 1 subunit


chrX_-_111463149 0.007 ENSMUST00000096348.3
ENSMUST00000113428.2
 Rps6ka6

ribosomal protein S6 kinase polypeptide 6

chr5_+_98329298 0.002 ENSMUST00000080333.3
 1700007G11Rik
RIKEN cDNA 1700007G11 gene
chr4_+_116558056 0.001 ENSMUST00000106475.1
 Gpbp1l1
GC-rich promoter binding protein 1-like 1
chr2_-_127788854 0.000 ENSMUST00000028857.7
ENSMUST00000110357.1
 Nphp1

nephronophthisis 1 (juvenile) homolog (human)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.1 0.4 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.1 0.8 GO:0002317 plasma cell differentiation(GO:0002317)
0.1 0.3 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.3 GO:0009597 detection of virus(GO:0009597)
0.1 0.2 GO:0001827 inner cell mass cell fate commitment(GO:0001827)
0.1 0.3 GO:0061511 centriole elongation(GO:0061511)
0.0 0.2 GO:0010796 regulation of multivesicular body size(GO:0010796) multivesicular body assembly(GO:0036258)
0.0 0.1 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.0 0.7 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 0.1 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 0.3 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.0 0.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.0 0.3 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.5 GO:1902170 cellular response to reactive nitrogen species(GO:1902170)
0.0 0.1 GO:0070889 platelet alpha granule organization(GO:0070889)
0.0 0.2 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.2 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.0 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.2 GO:1904668 mitotic spindle midzone assembly(GO:0051256) positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 0.2 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.2 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.1 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0 0.2 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.1 GO:0098734 protein depalmitoylation(GO:0002084) positive regulation of pinocytosis(GO:0048549) macromolecule depalmitoylation(GO:0098734)
0.0 0.2 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.0 GO:1905077 negative regulation of interleukin-17 secretion(GO:1905077)
0.0 0.1 GO:0042748 circadian sleep/wake cycle, non-REM sleep(GO:0042748)
0.0 0.1 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 0.0 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.0 GO:1901608 dense core granule localization(GO:0032253) cellular response to isoquinoline alkaloid(GO:0071317) regulation of vesicle transport along microtubule(GO:1901608) dense core granule transport(GO:1901950) regulation of dense core granule transport(GO:1904809) positive regulation of dense core granule transport(GO:1904811)
0.0 0.1 GO:0006012 galactose metabolic process(GO:0006012)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.7 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.4 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0032021 NELF complex(GO:0032021)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.1 GO:0097433 dense body(GO:0097433)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.2 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.1 0.9 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.4 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 0.4 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 0.7 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.2 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.2 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.1 GO:0004335 galactokinase activity(GO:0004335)
0.0 0.1 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0000992 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.3 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.3 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.3 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins